Patents Represented by Attorney Rita D. Vacca

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  • Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
    Patent number: 5221485
    Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals are purified by passing through a cross-linked reverse osmosis membrane.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: June 22, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
  • Purification of crude Ioversol using continuous deionization
    Patent number: 5210300
    Abstract: The use of continuous deionization as an alternative or substitute method for the purification of a crude contrast agent.
    Type: Grant
    Filed: September 25, 1991
    Date of Patent: May 11, 1993
    Assignee: Malinckrodt Medical, Inc.
    Inventor: Mills T. Kneller
  • Compositions for magnetic resonance imaging
    Patent number: 5208375
    Abstract: Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: May 4, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Dennis A. Moore, Rebecca A. Wallace
  • Process for preparing nonionic X-ray contrast agents
    Patent number: 5191120
    Abstract: Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino-1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2-propanediol are provided.
    Type: Grant
    Filed: September 24, 1991
    Date of Patent: March 2, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mills T. Kneller, Youlin Lin, James R. Wheatley
  • Synthesis of ioversol using chloroacetyl chloride
    Patent number: 5177261
    Abstract: The use of chloroacetylchloride as an alternative or substitute reagent for acetoxychloride in the synthesis of N,N'- bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophth alamide.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: January 5, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: William Z. McCarthy, Mills T. Kneller, Youlin Lin, David H. White
  • Purification of crude Ioversol using reverse osmosis
    Patent number: 5160437
    Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: November 3, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
  • Composition for magnetic resonance imaging
    Patent number: 5138040
    Abstract: Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: August 11, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Dennis A. Moore, Rebecca A. Wallace