Abstract: A process for the recovery and purification of 1,1,2-trichloroethane from the intermediates produced for the production of ioversol for reuse thereof.
Abstract: The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxy-ethyl)glycolamido-2,4,6-triio doisophthalamide.
Type:
Grant
Filed:
March 25, 1994
Date of Patent:
December 6, 1994
Assignee:
Mallinckrodt Medical PMC
Inventors:
William Z. McCarthy, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White
Abstract: A process for the separation of amyl acetate, a high boiling point solvent from various high boiling point corrosive impurities, namely, bromoethyl acetate, in an industrial setting to allow for reuse through continuous recycling thereof.
Type:
Grant
Filed:
February 26, 1993
Date of Patent:
October 18, 1994
Assignee:
Mallinckrodt Medical PMC
Inventors:
William Z. McCarthy, Michael J. Gentilcore
Abstract: The compound N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6 -triiodoisophthalamide and similar such compounds may be used as x-ray contrast agents which are water-soluble, safe and in an aqueous solution are non-viscous. Methods of preparing N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6 -triiodoisophthalamide and the analogous compounds are provided.
Type:
Grant
Filed:
May 8, 1992
Date of Patent:
October 18, 1994
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
Youlin Lin, Rebecca A. Wallace, David H. White
Abstract: A pressure monitoring device for indicating to the administrator of an injection to a patient that an excess of force has been exerted on the plunger and thereby the fluids contained within the syringe.
Abstract: The invention relates to a substantially transparent container for liquids on one side of which are opaque light and opaque dark areas of color observable through the container for evaluating contained liquid for particulate impurities. The container is particularly useful for pharmaceutical liquids.
Abstract: The use of azeotropic distillation to dry 5-amino-N,N'bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, an intermediate in the production of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisophthalamide.
Type:
Grant
Filed:
April 16, 1991
Date of Patent:
October 26, 1993
Assignee:
Mallinckrodt Medical, Inc.
Inventors:
William Z. McCarthy, Mills T. Kneller, Youlin Lin, David H. White
Abstract: A sanitary sampling system for attachment to a tube portion of a fluid containing enclosure. The sanitary sampling system is comprised of a rigid stem portion for attachment to the tube portion of the fluid enclosure, a stopper portion having a lower portion for insertion into the rigid stem portion and tube portion, a disk-shaped orifice plate fitting for placement on the upper surface of the stopper portion and an adjustable clamp for adjustment around the stem portion, orifice plate fitting and stopper portions of the sanitary sampling system. The sanitary sampling system is designed to enable the stem portion, stopper portion and orifice plate fitting to interlock to form an air-tight and leak-free seal when the adjustable clamp is tightened.