Abstract: This invention provides processes for the preparation of a compound of Formula I:
Y—C(═O)—C(R1)(R2)—CH2—S(O)nR3
wherein:
Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl or lower acyl;
R1 is hydrogen or lower alkyl;
R2 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, or R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl or heterocyclo group;
R3 is aryl; and
n is 0, 1 or 2.
The invention also provides novel aryl haloalkyl sulfide intermediates useful for the preparation of compounds of Formula I and novel methods of preparing aryl alkyl sulfides.
Type:
Grant
Filed:
November 9, 2001
Date of Patent:
July 16, 2002
Assignee:
Syntex (U.S.A.) LLP
Inventors:
Jeffrey Allen Campbell, Lawrence Emerson Fisher, Charles Alois Dvorak, Paul Leo McGrane