Patents Represented by Attorney Robert A. Conrad

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  • Isoquinoline derivatives as immune regulants
    Patent number: 4670442
    Abstract: This invention provides for certain substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones, formulations of the compounds, and a method for their use in suppressing the immune response in mammals.
    Type: Grant
    Filed: August 10, 1983
    Date of Patent: June 2, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jack B. Campbell, Edward R. Lavagnino
  • Inotropic agents
    Patent number: 4670445
    Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: June 2, 1987
    Assignee: Eli Lilly and Company
    Inventor: Wayne A. Spitzer
  • Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
    Patent number: 4667030
    Abstract: An antineoplastic dimeric indole-dihydroindole (vinca) alkaloid carrying a hydrazine succinimide group at C-3, capable of forming conjugates with a diacid at C-4.
    Type: Grant
    Filed: June 17, 1985
    Date of Patent: May 19, 1987
    Assignee: Eli Lilly and Company
    Inventor: George J. Cullinan
  • Oxiranes
    Patent number: 4665189
    Abstract: There are described compounds of formula ##STR1## in which n is 0, 1 or 2, R.sup.1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R.sup.2 is optionally substituted phenyl or C.sub.1-10 alkyl optionally substituted by one or more substituents selected from optionally protected hydroxyl, optionally protected carboxyl, nitrile, optionally protected tetrazolyl, --COR.sup.6 where R.sup.6 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, an optionally protected amino acid residue or --NR.sub.2.sup.7 where each R.sup.7 is hydrogen or C.sub.1-4 alkyl, and --NHR.sup.8 where R.sup.8 is hydrogen, a protecting group, an optionally protected amino acid residue, C.sub.1-4 alkyl or --COR.sup.9 where R.sup.9 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy, and R.sup.3, R.sup.4 and R.sup.5 are each selected from hydrogen, carboxyl, C.sub.2-5 alkoxycarbonyl, C.sub.1-4 alkyl, C.sub.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 12, 1987
    Assignee: Lilly Industries Limited
    Inventors: Stephen R. Baker, William B. Jamieson, Alec Todd
  • Leukotriene antagonists
    Patent number: 4661505
    Abstract: This invention provides novel alkane derivatives which are leukotriene antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes.
    Type: Grant
    Filed: November 3, 1982
    Date of Patent: April 28, 1987
    Assignee: Eli Lilly and Company
    Inventors: Winston S. Marshall, John P. Verge
  • Aromatase inhibiting .alpha.,.alpha.-diphenyl-4(5)imidazole-methanes or -ethanes
    Patent number: 4661508
    Abstract: This invention provides certain imidazole derivatives, their pharmaceutical formulations, and their use in a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
    Type: Grant
    Filed: May 10, 1985
    Date of Patent: April 28, 1987
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor
  • Aromatase inhibiting imidazole derivatives
    Patent number: 4659730
    Abstract: This invention provides certain azole derivatives and their pharmaceutical formulations. Also provided is a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering the azole derivatives.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: April 21, 1987
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones, Harold M. Taylor
  • Dihydropyridines useful in the treatment of angina and stroke
    Patent number: 4659717
    Abstract: This invention provides certain substituted dihydropyridines, their pharmaceutical formulations, and their use for causing vasodilation in mammals.
    Type: Grant
    Filed: August 21, 1985
    Date of Patent: April 21, 1987
    Assignee: Eli Lilly and Company
    Inventor: James H. Wikel
  • Inotropic agents
    Patent number: 4647564
    Abstract: This invention provides certain pyridazinone derivatives, their pharmaceutical formulations, and their use as positive inotropic agents.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventor: David W. Robertson
  • Intermediates for anticonvulsant agents
    Patent number: 4642379
    Abstract: This invention provides certain 4-acylamino benzamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: February 10, 1987
    Assignee: Eli Lilly and Company
    Inventors: Edward E. Beedle, David W. Robertson
  • Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
    Patent number: 4636502
    Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: January 13, 1987
    Assignee: Eli Lilly and Company
    Inventor: Wayne A. Spitzer
  • Anticonvulsant agents
    Patent number: 4632939
    Abstract: This invention provides certain benzamide derivatives of the formula: ##STR1## wherein Z is bond, --CH.sub.2 --, or CHCH.sub.3 ; A is --CH.sub.2 --, or CH.sub.2 CH.sub.2 --; and represents a single or double bond; and their pharmaceutical formulations and their use as anticonvulsant agents.
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: December 30, 1986
    Assignee: Eli Lilly and Company
    Inventors: Edward E. Beedle, David W. Robertson
  • 6-(pyridinylphenyl)dihydropyridazinones as inotropic agents
    Patent number: 4631279
    Abstract: This invention provides certain pyridazinone derivatives, their pharmaceutical formulations, and their use as positive inotropic agents.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: December 23, 1986
    Assignee: Eli Lilly and Company
    Inventor: David W. Robertson
  • Anticonvulsant agents
    Patent number: 4629740
    Abstract: This invention provides for certain benzamide derivatives and their pharmaceutical formulations and their use as anticonvulsant agents.
    Type: Grant
    Filed: April 10, 1984
    Date of Patent: December 16, 1986
    Assignee: Eli Lilly and Company
    Inventor: David W. Robertson
  • Stable oncolytic formulations
    Patent number: 4619935
    Abstract: Stable, sterile, ready-to-use formulations of oncolytic vincristine are provided.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: October 28, 1986
    Assignee: Eli Lilly and Company
    Inventor: Robert L. Robison
  • Antiasthmatic method
    Patent number: 4617311
    Abstract: This invention provides a method of treating asthma in mammals which comprises administering an effective amount of Pinacidil.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: October 14, 1986
    Assignee: Eli Lilly and Company
    Inventor: Peter P. K. Ho
  • Inotropic agents
    Patent number: 4617302
    Abstract: This invention provides certain pyridazinone derivatives, their pharmaceutical formulations, and their use as positive inotropic agents.
    Type: Grant
    Filed: October 15, 1984
    Date of Patent: October 14, 1986
    Assignee: Eli Lilly and Company
    Inventor: David W. Robertson
  • Antiinflammatory method
    Patent number: 4612330
    Abstract: This invention provides a method of treating inflammation and arthritis employing certain prostanoic acid derivatives. Pharmaceutical formulations employing these derivatives are also provided.
    Type: Grant
    Filed: February 4, 1985
    Date of Patent: September 16, 1986
    Assignee: Eli Lilly and Company
    Inventors: Jon S. Mynderse, Rosanne Bonjouklian
  • Aromatase inhibiting derivatives of .alpha.,.alpha.-bis(4-halophenyl)methyltetrazoles and triazoles
    Patent number: 4609666
    Abstract: This invention provides certain azole derivatives, their pharmaceutical formulations, and a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: September 2, 1986
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones, Harold M. Taylor
  • Aromastase inhibiting .alpha.,.alpha.-diarylimidazole-4(5)-propionitriles, .alpha.,.alpha.-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
    Patent number: 4605661
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain imidazole derivatives. Pharmaceutical formulations of the imidazole derivatives and certain imidazoles are also provided.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 12, 1986
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Richard P. Pioch