Patents Represented by Attorney Robert A. Miller
  • Patent number: 6329386
    Abstract: A compound having the formula or a pharmaceutically acceptable salt or prodrug thereof, is an immunomodulatory agent and is useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: December 11, 2001
    Assignee: Abbott Laboratories
    Inventor: Karl W. Mollison
  • Patent number: 6143749
    Abstract: The present invention provides new heterocyclic substituted cyclopentane compounds that are useful in inhibiting adenosine kinase. The present invention also provides pharmaceutical compositions containing such compounds and methods of using such compounds for inhibiting adenosine kinase.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: November 7, 2000
    Assignee: Abbott Laboratories
    Inventors: Shripad S. Bhagwat, Marlon Daniel Cowart
  • Patent number: 6121257
    Abstract: The present invention relates to novel compounds of formula I: ##STR1## which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the preparation of compounds of formula I, compositions containing such compounds, and methods of using such compounds.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: September 19, 2000
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Indrani W. Gunawardana
  • Patent number: 6030969
    Abstract: A compound having the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, pain, nociperception, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods for preparation thereof.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: February 29, 2000
    Assignee: Abbott Laboratories
    Inventors: Shripad S. Bhagwat, Richard J. Perner, Yu-Gui Gu
  • Patent number: 6015815
    Abstract: A compound having the formula ##STR1## or a pharmaceutically acceptible salt or prodrug thereof, is an immunomodulatory agent and is usefull in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: January 18, 2000
    Assignee: Abbott Laboratories
    Inventor: Karl W. Mollison
  • Patent number: 5837776
    Abstract: Aqueous dispersions of water soluble nonionic and anionically charged vinyl and allyl addition polymers can be obtained by polymerizing in the presence of an anionically charged water soluble polymer stabilizer in a saturated salt solution. Methods for the preparation of these polymers, and their compositions are disclosed.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: November 17, 1998
    Assignee: Nalco Chemical Company
    Inventors: Radhakrishnan Selvarajan, John R. Hurlock
  • Patent number: 5772894
    Abstract: Disclosed are the Rhodamine B esters of hydroxy C.sub.2 -C.sub.6 lower alkyl acrylates. Specifically, the hydroxy lower alkyl radical is a linear hydroxy lower alkyl radical having the hydroxy group attached to the terminal carbon atom. Also shown are copolymers of diallyldimetyl ammonium chloride which contains from 0.01-2 mole percent of these Rhodamine B esters and their use in treating industrial waters.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: June 30, 1998
    Assignee: Nalco Chemical Company
    Inventors: William J. Ward, Jeffrey R. Cramm, Peter E. Reed, Brian S. Johnson
  • Patent number: 5750034
    Abstract: The invention comprises a method for clarifying ink-laden water obtained from the recycling of paper stocks by treating said water with a conventional coagulant followed by treatment with a hydrophilic dispersion polymer. The hydrophilic dispersion flocculant of the invention is a copolymer of dimethylaminoethyl (meth)acrylate methyl chloride quat (DMAEA.multidot.MCQ) cationic monomer and (meth)acrylamide (AcAm). Following dosing with the flocculant, a floc is formed. The floc contains ink and impurities which are removed from the water process stream by means of solid liquid separation; the solid liquid separation comprising a dissolved air flotation method.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: May 12, 1998
    Assignee: Nalco Chemical Company
    Inventors: Jane B. Wong Shing, Karen R. Tubergen
  • Patent number: 5746924
    Abstract: The invention comprises a method of inhibiting the formation of foulants and residues, gums and precipitates, polymeric tars and other highly oxidized carbonaceous tars which can be formed in the process of manufacture and recovery of acrylonitrile. The method comprises adding to the liquid or gaseous phases passing through, or stored in acrylonitrile process equipment, an effective antifouling amount of a dispersant which is stable in the environment within an acrylonitrile process and is neutral to the equipment used for the manufacture of acrylonitrile.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: May 5, 1998
    Assignee: Nalco/Exxon Energy Chemicals, L.P.
    Inventors: Fredrick L. Cooper, Piotr A. Kibala, Michael C. Weismiller
  • Patent number: 5736405
    Abstract: A method for the determination of the concentration of additives in boiler water systems, by which polymeric additives are utilized to monitor and treat boiler water systems.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: April 7, 1998
    Assignee: Nalco Chemical Company
    Inventors: Joseph C. Alfano, Martin R. Godfrey, Radhakrishnan Selvarajan, Mary C. Uhing
  • Patent number: 5734098
    Abstract: Thickness-shear mode resonators which simultaneously measure mass deposition and fluid properties can be utilized to monitor petroleum processing, petrochemical and water treatment systems. Specialty chemical additive materials can be accurately and instantaneously added to control conditions detected by the thickness-shear mode resonators. The thickness-shear mode resonators are piezoelectric crystals used in conjunction with oscillator circuitry that can determine mass as well as viscosity and/or density of a fluid in contact with the piezoelectric surface.
    Type: Grant
    Filed: March 25, 1996
    Date of Patent: March 31, 1998
    Assignee: Nalco/Exxon Energy Chemicals, L.P.
    Inventors: Paul R. Kraus, Robert D. McClain, Michael K. Poindexter
  • Patent number: 5733438
    Abstract: Aromatic compounds in small amounts function as antifoulant additives in pyrolysis furnaces which are subjected to elevated temperatures from about 500.degree. C. to about 1200.degree. C. when thermally convening hydrocarbons to ethylene as well as other useful products. These furnaces produce material that deposits and accumulates upon furnace surfaces including furnace radiant coils and transfer line exchangers. The present antifoulant additives inhibit and suppress the formation and deposition of material on furnace surfaces. The present invention is a method for inhibiting the formation of coke on the surfaces of a radiant heating section of a pyrolysis furnace and the surfaces immediately downstream of such section in contact with a hydrocarbon feedstock which comprises decoking the pyrolysis furnace, and prior to processing the hydrocarbon feedstock, adding an inhibiting compound to the pyrolysis furnace.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: March 31, 1998
    Assignee: Nalco/Exxon Energy Chemicals, L.P.
    Inventors: Youdong Tong, Michael K. Poindexter, C. Tom Rowe
  • Patent number: 5726267
    Abstract: Methods for dispersing and binding ceramic materials in aqueous media are disclosed. The methods utilize water-soluble polymers having pendant derivatized amide, ester or ether functionalities for dispersing and binding various classes of ceramic materials.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: March 10, 1998
    Assignee: Nalco Chemical Company
    Inventors: Christopher P. Howland, Kevin J. Moeggenborg, John D. Morris, Peter E. Reed, Jiansheng Tang, Jin-shan Wang
  • Patent number: 5723550
    Abstract: EPDM elastomer is sulfonated and neutralized by a bulk process involving mechanical mixing at low temperatures in the sulfonating and neutralizing steps. The EPDM is discharged from the mixing process as finely divided particles having a low bulk density.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: March 3, 1998
    Assignee: Nalco/Exxon Energy Chemicals, L.P.
    Inventors: Cruise K. Jones, David B. Acker, Dennis A. Williams, Robert D. Lundberg, Vijay Swarup
  • Patent number: 5716629
    Abstract: The invention is a composition for controlling microbiological growth which comprises a combination of 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane and tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione. The invention has particular utility as a composition for controlling microbiological growth in a slurry of paper machine additives such as precipitated calcium carbonate which comprises adding to said slurry a combination of 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane and tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione.The invention is also a method for controlling bacterial and fungal growth which comprises a combination of 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane and tetrahydro-3,5-dimethyl-2H-1,3,5-thiadiazine-2-thione.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: February 10, 1998
    Assignee: Nalco Chemical Company
    Inventors: Linda R. Robertson, Sasireka S. Ramesh
  • Patent number: 5716530
    Abstract: In the Bayer process for producing alumina from bauxite of the type wherein the bauxite is added to a caustic solution to produce a soluble aluminate solution and an insoluble red mud fraction which is then subjected to one or more separation steps to produce a thickener overflow which is then subjected to a Sand Filter to polish the thickener overflow the improvement which comprises treating the thickener overflow with a solids removal efficiency improving amount of a biopolymer.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: February 10, 1998
    Assignee: Nalco Chemical Company
    Inventors: Michael G. Strominger, Keith D. Gibbs
  • Patent number: 5714387
    Abstract: A method of determining the dosage of dust control agents applied to coal is disclosed. The method comprises the steps of: (1) treating the coal, with a small amount of a dust control agent containing a compatible fluorescent dye; (2) extracting the treated coal with a polar solvent for the freeze-release agent and determining the fluorescence of such extract; (3) extracting a similar treated coal sample to which a known amount of the dust control agent has been further added and determining the fluorescence of this extract; (4) setting up a proportionality between the fluorescence values of extracts (2) and (3) with the corresponding dosages of dust control agents and solving for the unknown dosage originally applied to the coal.
    Type: Grant
    Filed: February 28, 1996
    Date of Patent: February 3, 1998
    Assignee: Nalco Chemical Company
    Inventors: Roger W. Fowee, J. David Martin, Everett C. Phillips
  • Patent number: 5714664
    Abstract: The disclosure is a process for inhibiting corrosion in condensing systems comprising wet hydrocarbons and chloride which comprises feeding a mixture of amines to the condensing system to elevate the pH profile of condensed water above the range in which severe corrosion of system internals can occur. The amine blend is formulated to preclude deposition and accumulation of the hydrochloride salts of the amines above the water dewpoint and is optimized to the condensing system to minimize amine treat rate. In one embodiment, the amine blend feed rate is controlled using a small condensing system which condenses a slipstream of gas taken from the system upstream of the condensing zone and continually measures the pH profile in the condensing zone.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: February 3, 1998
    Assignee: Nalco Chemical Company
    Inventors: Paul Fearnside, Christopher J. Murphy
  • Patent number: 5714055
    Abstract: A method of inhibiting the formation of fouling deposits occurring on the surfaces of an alkaline scrubber used to wash acid gases generated during the manufacture of olefins, which deposits are formed during the scrubbing of pyrolytically produced hydrocarbons contaminated with oxygen-containing compounds with a caustic solution having a pH>7, which comprises adding an effective depositing-inhibiting amount of a caustic solution-soluble substituted aromatic amine selected from the group consisting of: 2-aminophenol, 4-aminophenol, 4-aminobenzenesulfonic acid and salts thereof, 4-amino-o-cresol, 3-aminophenol, 2-aminobenzoic acid and salts thereof, 3-aminobenzoic acid and salts thereof, and 4-aminobenzoic acid and salts thereof to the caustic solution. A preferred substituted aromatic amine is the sodium salt of 4-amino- benzenesulfonic acid in aqueous solution.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: February 3, 1998
    Assignee: Nalco/Exxon Energy Chemicals, L.P.
    Inventors: Vincent E. Lewis, Natu R. Patel
  • Patent number: 5711923
    Abstract: The invention comprises a process for improved flocculation of Bayer process red mud-containing slurry. The improvement comprises adding to the red mud-containing liquor a hydroxymethyl diphosphonic acid polymer optionally in addition to the conventional flocculant. The polymer is added to the red mud-containing liquor in an amount sufficient to reduce the concentration of suspended solids in the supernatant phase and/or increase the rate of sedimentation.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: January 27, 1998
    Assignee: Nalco Chemical Company
    Inventors: Paul J. Harris, Robert P. Mahoney, Manian Ramesh