Abstract: The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.
Type:
Grant
Filed:
December 7, 2004
Date of Patent:
October 3, 2006
Assignee:
Allergan, Inc.
Inventors:
Michael E. Garst, Lloyd Jay Dolby, Shervin Esfandiari, Alfred Arthur Avey, Jr.
Abstract: The invention concerns combinations of alpha adrenergic agents such as brimonidine and its derivatives as represented by formula (I) below
wherein each Y is independently selected from the group consisting of N, N—CH3, O, S and C—R1; R1 is hydrogen, lower alkyl or oxo; R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl and lower alkenyl; n is an integer from 1 to 3; and a broken line beside a solid line indicates either a single or a double bond with the proviso that when n=1, both bonds from Y to C—R1 cannot be double bonds,
and prostaglandins known in the art to cause lowering of intraocular pressure
which are useful in compositions, methods of treatment and articles of manufacture for the treatment of glaucoma and alleviation of elevated intraocular pressure and providing neuroprotection.
Abstract: The invention is a fire-resistant, light stable textile structure comprising a mat of fibers held together with a vinylidene chloride interpolymer, containing a light-stabilizing amount of a nitrile-containing comonomer in interpolymerized form.