Patents Represented by Attorney Robert E. Nail

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  • Conversion of a watson-crick DNA to a hoogsteen-paired duplex
    Patent number: 6362322
    Abstract: A method is described for obtaining Hoogsteen-paired pyrimidine*purine duplexes, either by heating a triplex to dissociate a Watson-Crick paired pyrimidine strand or by linking two parallel strands at their 5′ ends is disclosed. This duplex can be used as a new type of antisense molecule to pair with an RNA pyrimidine target sequence within an mRNA molecule. This duplex can also be used as a new type of antigene molecule to pair with a single-stranded DNA pyrimidine target sequence within the genome.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: March 26, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Donald M. Gray, Gihan M. Hashem
  • Seven sided table
    Patent number: D511256
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: November 8, 2005
    Inventor: David R. Searl
  • Spring table
    Patent number: D520269
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 9, 2006
    Inventor: David R. Searl