Patents Represented by Attorney Robert J. Harris
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Patent number: 7331836Abstract: An article of aquatic apparel including one or more handles. The handles are secured to the apparel and allow for passengers riding along to hold onto the wearer of the article. The handles can be configured as gripping slots or projecting straps.Type: GrantFiled: January 10, 2005Date of Patent: February 19, 2008Inventor: William R. Harris
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Patent number: 5861392Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: August 5, 1996Date of Patent: January 19, 1999Assignee: Zeneca LimitedInventor: Scott Carson Miller
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Patent number: 5731309Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: October 24, 1995Date of Patent: March 24, 1998Assignee: Zeneca LimitedInventors: Peter R. Bernstein, Scott C. Miller
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Patent number: 5710169Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4, and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: October 24, 1995Date of Patent: January 20, 1998Assignee: Zeneca LimitedInventor: Keith Russell
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Patent number: 5705505Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: September 26, 1996Date of Patent: January 6, 1998Assignee: Zeneca LimitedInventors: Ashokkumar Bhikkappa Shenvi, Robert Toms Jacobs, Scott Carson Miller, Cyrus John Ohnmacht, Jr., Chris Allan Veale
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Patent number: 5677317Abstract: Compounds of formula I ##STR1## wherein J, B, L, X, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: April 8, 1996Date of Patent: October 14, 1997Assignee: Zeneca LimitedInventor: Scott Carson Miller
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Patent number: 5668137Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, n, m and Het have any of the meanings defined herein, and their pharmaceutically-acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processess for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: June 20, 1996Date of Patent: September 16, 1997Assignee: Zeneca Ltd.Inventors: Paul John Phillips, Peter Grahame Ballard, Robert Hugh Bradbury, Roger James
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Patent number: 5654299Abstract: The present invention concerns the novel use of aryl substituted heterocycles of formula I, set out below, which antagonize the pharmacological actions of one of ent endogenous neuropeptide tachykinins an the neurokinin 2 (NK2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the aryl substituted heterocycles for use in such treatment. Certain novel aryl substituted heterocycles of formula I and novel intermediates for their manufacture are also provided.Type: GrantFiled: April 18, 1994Date of Patent: August 5, 1997Assignee: Zeneca LimitedInventors: Ashokkumar Bhikkappa Shenvi, Robert Toms Jacobs
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Patent number: 5641793Abstract: The invention concerns pharmaceuticaly useful compounds of the formula I, in which Q, A.sup.1, A.sup.2, A.sup.3, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutically compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: May 12, 1995Date of Patent: June 24, 1997Assignee: Zeneca LimitedInventor: Robert Hugh Bradbury
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Patent number: 5635509Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: May 1, 1995Date of Patent: June 3, 1997Assignee: Zeneca LimitedInventors: Robert T. Jacobs, Scott C. Miller, Ashokkumar B. Shenvi, Cyrus J. Ohnmacht, Jr., Chris A. Veale
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Patent number: 5602138Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: December 2, 1994Date of Patent: February 11, 1997Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5589489Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: December 12, 1994Date of Patent: December 31, 1996Assignee: Zeneca LimitedInventors: Ashokkumar B. Shenvi, Robert T. Jacobs, Scott C. Miller, Cyrus J. Ohnmacht, Jr., Chris A. Veale
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Patent number: 5576333Abstract: The present invention concerns novel carboxamide derivatives of formula I, ##STR1## wherein R.sup.1, R.sup.2, J, m, and M have any of the values defined in the specification, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.Type: GrantFiled: November 3, 1993Date of Patent: November 19, 1996Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5567700Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: August 15, 1994Date of Patent: October 22, 1996Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5559132Abstract: The present invention concerns novel carboxamide derivatives of formula I, set out hereinbelow which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.Type: GrantFiled: February 21, 1995Date of Patent: September 24, 1996Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5559131Abstract: The present invention concerns novel carboxamide derivatives of formula I, set out hereinbelow which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.Type: GrantFiled: February 21, 1995Date of Patent: September 24, 1996Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5534525Abstract: Compounds of formula I ##STR1## wherein J, B, L, X, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: October 31, 1994Date of Patent: July 9, 1996Assignee: Zeneca LimitedInventor: Scott C. Miller
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Patent number: 5521199Abstract: The present invention concerns the novel alkyl substituted heterocycles of formula I, set out below, wherein Q, Q.sup.1, Q.sup.2 and R have the values defined herein, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK.sup.2) receptor making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the alkyl substituted heterocycles for use in such treatment, methods for their use, and processes and novel intermediates for their manufacture.Type: GrantFiled: May 16, 1994Date of Patent: May 28, 1996Assignee: Zeneca LimitedInventors: Robert T. Jacobs, Ashokkumar B. Shenvi
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Patent number: 5521179Abstract: The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.Type: GrantFiled: April 8, 1993Date of Patent: May 28, 1996Assignee: Zeneca LimitedInventors: Peter R. Bernstein, Andrew Shaw, Royston M. Thomas, Peter Warner, Donald J. Wolanin
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Patent number: 5486529Abstract: The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.Type: GrantFiled: April 8, 1993Date of Patent: January 23, 1996Assignee: Zeneca LimitedInventors: Peter R. Bernstein, Andrew Shaw, Royston M. Thomas, Chris A. Veale, Peter Warner, Donald J. Wolanin