Patents Represented by Attorney Robert Kajubi

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  • Synthesis of morphine-6-glucuronide or one of the derivatives thereof
    Patent number: 8258298
    Abstract: The disclosure relates to a method for preparing morphine-6-glucuronide or one of the deritives thereof comprising reacting a compound of formula (I): wherein R1 is as defined in the disclosure, with a glucuronic acid derivative of formula (II): wherein PG, X, and R4 are as defined in the disclosure, in the presence of an aromatic solvent and trimethylsilyl trifluoromethanesulfonate; (ii) reacting the product obtained in step (i) with a strong basic agent; and then (iii) recovering the product obtained in step (ii).
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: September 4, 2012
    Assignee: Sanofi
    Inventors: Alain Dlubala, Claire Trecant, Isabelle Ripoche