Patents Represented by Attorney Robert L. Bernstein

Find this attorney in the Justia Lawyer Directory

  • Muscarinic antagonists
    Patent number: 6890936
    Abstract: The invention described herein are compounds in accordance with formula I: wherein R1, R2, R3, R4, R5, R6, R2, R8, R9, n, X, and Z are as defined herein, pharmaceutical compositions containing at least one compound of formula I, methods of preparation thereof, and methods of treating disorders with at least one compound of formula I or at least one compound of formula I in association with at least one acetylcholinesterase inhibitor.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: May 10, 2005
    Assignee: Schering Corporation
    Inventors: Craig D. Boyle, William J. Greenlee, Samuel Chackalamannil
  • Compounds for the treatment of inflammatory disorders
    Patent number: 6838466
    Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-? or combinations thereof.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: January 4, 2005
    Assignee: Schering Corporation
    Inventors: Zhaoning Zhu, Robert Mazzola, Zhuyan Guo, Brian J. Lavey, Lisa Sinning, Joseph Kozlowski, Brian McKittrick, Neng-Yang Shih
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Patent number: 6645966
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance. Also disclosed are novel Farnesyl Protein Transferase inhibitors.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: November 11, 2003
    Assignee: Schering Corporation
    Inventors: William T. Windsor, Patricia C. Weber, Corey O. Strickland, Michael Gelb
  • Compounds for the inhibition of farnesyl protein transferase
    Patent number: 6576639
    Abstract: Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: June 10, 2003
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Joseph M. Kelly, Alan K. Mallams, F. George Njoroge, Stacy W. Remiszewski, Arthur G. Taveras
  • Farnesyl protein transferase inhibitors
    Patent number: 6528523
    Abstract: The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: March 4, 2003
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Xiongwei Shi
  • Aqueous insecticidal pour-on formulation
    Patent number: 6492419
    Abstract: A topically acceptable aqueous pour-on formulation adapted for localized external application to an animal, which format includes an effective amount of a water insoluble insect growth regulator (IGR), a suspending agent, a surfactant or mixture of surfactants, and an aqueous carrier.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: December 10, 2002
    Assignee: Schering-Plough Animal Health Corp.
    Inventor: Stanley Shepherd
  • Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 6492381
    Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 Also disclosed are novel compounds of the formulas: and Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: December 10, 2002
    Assignee: Schering Corp.
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
    Patent number: 6440989
    Abstract: Novel phenyl-substituted tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: August 27, 2002
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, Joseph M. Kelly, Jay Weinstein, Ronald L. Wolin, Stuart B. Rosenblum
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6440974
    Abstract: Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents a five or six membered heterocycloalkyl ring having one or two heteroatoms selected from S or O. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: August 27, 2002
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Carmen Alvarez, Tarik Lalwani, Yi-Tsung Liu
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6432959
    Abstract: Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: August 13, 2002
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Ronald J. Doll, Johan A. Ferreira, Ashit Ganguly, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Jianping Chao, John J. Baldwin, Chia-Yu Huang, Ge Li
  • Sulfonamide inhibitors of farnesyl-protein transferase
    Patent number: 6426352
    Abstract: Novel tricyclic sulfonamide compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel sulfonamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: July 30, 2002
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Arthur G. Taveras, Ronald J. Doll, Viyyoor M. Girijavallabhan
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6410541
    Abstract: Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: June 25, 2002
    Assignee: Schering Corporation
    Inventors: Stacy W. Remiszewski, Ronald J. Doll, Carmen Alvarez, Tarik Lalwani
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6387905
    Abstract: Novel compounds of the formula: are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: May 14, 2002
    Assignee: Schering Corporation
    Inventors: F George Njoroge, Arthur G. Taveras, Ronald J. Doll, Tarik Lalwani, Carmen Alvarez, Stacy W. Remiszewski