Patents Represented by Attorney Robert S. Frieman
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Patent number: 4182129Abstract: A heat exchanger comprising:(a) a housing having an interior surface;(b) a thermally conductive member in intimate contact with the housing;(c) a thermally conductive element coaxially disposed in said housing and having an inner and an outer surface and in thermal communication with the member, wherein the inner surface of the element defines a first fluid passage, and wherein the interior surface of the housing and the outer surface of the element are in spaced relationship thereby defining a second fluid passage, the first and second fluid passages being in fluid communication;(d) a first port for maintaining the first fluid passage in fluid communication with a first external fluid;(e) a second port for maintaining the second fluid passage in fluid communication with a second external fluid; and(f) means for regulating the member's temperature; wherein heat is transferred between the member and the element via solid conduction.Type: GrantFiled: August 7, 1978Date of Patent: January 8, 1980Assignee: Beckman Instruments, Inc.Inventors: Otto Haunold, Malbone W. Greene
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Patent number: 4169143Abstract: A composition for use in the treatment of hemorrhoids comprising Vitamin E and a benzoin solution in a pharmacologically acceptable carrier.Type: GrantFiled: July 10, 1978Date of Patent: September 25, 1979Inventors: Irving Haimowitz, Ethel Arrington
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Patent number: 4162194Abstract: A kinetic assay is provided for determining the acid phosphatase in an aqueous solution by measuring the amount of of reduced coenzyme produced. The assay is based on the following coupled reactions:I. organic phosphate .sup.acid phosphatase PO.sub.4.sup.-3 +organic alcoholII. maltose+PO.sub.4.sup.-3 maltose phosphorylase glucose+ .beta.-D-glucose-1-phosphate;III. .beta.-D-glucose-1-phosphate .beta.-D-phosphoglucomutase glucose-6-phosphate;IV. glucose-6-phosphate+NAD glucose-6-phosphate dehydrogenase NADH+6-phosphogluconate.Type: GrantFiled: December 12, 1977Date of Patent: July 24, 1979Assignee: Beckman Instruments, Inc.Inventors: Kenneth J. Pierre, Ker-Kong Tung, Henriette Nadj
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Patent number: 4161425Abstract: A novel enzymatic reagent system is provided for assaying for total cholesterol in a liquid containing cholesterol, cholesterol esters, oxygen and substances which appear to inhibit the reactions between the enzymes and cholesterol and/or cholesterol esters. The novel reagent system comprises an aqueous solution of a buffering agent, cholesterol oxidase, cholesterol esterase, and a cationic surfactant in an amount sufficient to neutralize the effect of the inhibiting agents.Type: GrantFiled: March 18, 1977Date of Patent: July 17, 1979Assignee: Beckman Instruments, Inc.Inventor: Andrew W. Perry
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Patent number: 4159923Abstract: A kinetic assay is provided for determining the inorganic phosphate content in an aqueous solution by measuring the amount of reduced coenzyme produced. The assay is based on the following coupled reactions:I. maltose+PO.sub.4.sup.-3 maltose phosphorylase glucose+.beta.-D-glucose-1-phosphate;Ii. .beta.-d-glucose-1-phosphate .beta.-D-phosphoglucomutase glucose-6-phosphate;Iii. glucose-6-phosphate+NAD glucose-6-phosphate dehydrogenase NADH+6-phosphogluconate.Type: GrantFiled: December 12, 1977Date of Patent: July 3, 1979Assignee: Beckman Instruments, Inc.Inventors: Kenneth J. Pierre, Ker-Kong Tung, Henriette Nadj
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Patent number: 4158703Abstract: An improved T.sub.3 uptake test procedure characterized in that the separating agent employed therein comprises bovine serum albumin covalently coupled to a derivatized polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR1## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.A separating agent comprising bovine serum albumin covalently coupled to a derivatived polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR2## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.Type: GrantFiled: February 13, 1978Date of Patent: June 19, 1979Assignee: Beckman Instruments, Inc.Inventor: Alan J. Polito
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Process for preparing a biological composition for use as a reference control in diagnostic analysis
Patent number: 4158544Abstract: A process for making a biological composition for use as a blood serum reference composition in diagnostic analysis. The process comprises:(a) adding calcium to citrated plasma and mixing well to form decitrated plasma;(b) adding thrombin to the decitrated plasma and mixing well to form a clot of fibrin;(c) performing at least one freeze-thaw routine on the clot to cause the fibrin to contract;(d) removing the fibrin to thereby obtain serum;(e) molecular washing and ultrafiltering the serum and thereby obtaining concentrated serum; and(f) adding to the concentrated serum at least one alkylene polyol having from 2-5 carbon atoms in an amount such that said composition's non-biological component comprises from about 40 to about 85 weight percent water and from about 15 to about 60 weight percent of said alkylene polyol.Type: GrantFiled: July 17, 1978Date of Patent: June 19, 1979Assignee: Beckman Instruments, Inc.Inventor: Allan L. Louderback -
Patent number: 4106671Abstract: An automatically controlled liquid dispensing system including a reagent dispenser adapted to function as an intermediate container for dispensing relatively small controlled volumes of liquid to an associated receiving system in a continuous "demand" mode, this dispenser being indirectly monitored to be automatically and continually replenished after liquid is withdrawn therefrom, using a simple photoelectric liquid level monitor system including a fail-safe overflow control arrangement.Type: GrantFiled: March 21, 1977Date of Patent: August 15, 1978Assignee: Beckman Instruments, Inc.Inventor: Thomas Davy Sharples
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Patent number: 4081244Abstract: A method of separating free from bound fractions in an immunoassay procedure of the type wherein a solution is contacted with a composite comprising a finely divided, activated, polysaccharide matrix covalently coupled to a primary antibody, wherein the improvements comprise:(a) coupling an .alpha.,.omega.-diaminospacer to said finely divided, activated, polysaccharide matrix via one of said .alpha.,.omega.-diaminospacers's amino groups thereby forming a finely divided, derivatized, polysaccharide matrix;(b) covalently coupling said finely divided, derivatized, polysaccharide matrix to an antibody selected from a group consisting of primary and secondary antibodies via a bifunctional coupling agent having a formula ##STR1## WHEREIN N IS AN INTEGER FROM 1 AND 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2; AND(c) using a polysaccharide matrix having an average wet maximum dimension of 1 to 18 .mu..Type: GrantFiled: May 3, 1976Date of Patent: March 28, 1978Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, William S. Knight
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Patent number: 4081525Abstract: An in vitro radioimmunoassay procedure for measuring an amount of steroid in a sample wherein a separate serum protein inactivation step is eliminated. The separate protein serum inactivation step is eliminated by employing a solution wherein the solvent comprises from about 0 to about 10% of a water miscible organic solvent and from about 90 to about 100% of a buffer having a pH of from about 3 to about 6.Type: GrantFiled: August 16, 1976Date of Patent: March 28, 1978Assignee: Beckman Instruments, Inc.Inventors: William S. Knight, Barbara J. Kelley
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Patent number: 4081246Abstract: An improved method of separating free from bound fractions in a solid phase column immunoassay procedure of the type wherein a solution is contacted with a composite comprising an activated polysaccharide matrix covalently coupled to a primary antibody, wherein the improvements comprise:(a) coupling an .alpha.,.omega.-diaminospacer to said activated polysaccharide matrix via one of said .alpha.,.omega.-diamino-spacer's amino groups thereby forming a derivatized polysaccharide matrix; and(b) covalently coupling said derivatized polysaccharide matrix to an antibody selected from a group consisting of primary and secondary antibodies via a bifunctional coupling agent having a formula ##STR1## WHEREIN N IS AN INTEGER FROM 1 AND 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.Type: GrantFiled: May 3, 1976Date of Patent: March 28, 1978Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, William S. Knight
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Patent number: 4081245Abstract: A method of separating free from bound fractions in an immunoassay procedure of the type wherein a solution is contacted with a composite comprising a derivatized polysaccharide matrix covalently coupled to an antibody by a bifunctional coupling agent, wherein the improvement comprises selecting said bifunctional coupling agent from a group comprising ##STR1## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.Type: GrantFiled: May 3, 1976Date of Patent: March 28, 1978Assignee: Beckman Instruments, Inc.Inventor: Alan J. Polito
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Patent number: 4070517Abstract: Disclosed herein are powder compositions useful for making conductors, e.g., microcircuit conductors, end terminations for capacitors, electrodes for gas discharge display devices, etc. The compositions comprise inorganic powders dispersed in an inert vehicle and are printed and fired in the conventional manner on dielectric substrates. The inorganic powders comprise a mixture of nickel and/or aluminum or copper and boron. Glass powder and/or silicon powder may also be present.Type: GrantFiled: July 8, 1976Date of Patent: January 24, 1978Assignee: Beckman Instruments, Inc.Inventor: Casimir W. Kazmierowicz
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Patent number: 4069305Abstract: Derivatives of steroids containing an imidazole group specifically bind to the desired antibody without nonspecifically binding to other substances (e.g., proteins in a patient's plasma or serum and the surfaces of reaction vessels).Type: GrantFiled: May 10, 1976Date of Patent: January 17, 1978Assignee: Beckman Instruments, Inc.Inventors: Alan J. Polito, William S. Knight
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Patent number: 3965197Abstract: There is disclosed a process for the preparation of completely brominated derivatives of aromatic compounds comprising one or more phenyl groups which may contain substituents, side chains or be partially-brominated. The complete bromination is effected by utilizing liquid bromine as a reaction solvent whereby the starting aromatic material is reacted with an excess of bromine which contains a bromination catalyst and the mixture is refluxed for a sufficient time. Use of these brominated derivatives as fire retarding agents is nylon and polyester is also disclosed.Type: GrantFiled: January 17, 1972Date of Patent: June 22, 1976Assignee: Michigan Chemical CorporationInventor: Heinrich Stepniczka
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Patent number: 3941827Abstract: A process is disclosed for preparing halogenated hydrocarbyl nitriles comprising reacting a metal or ammonium cyanide with a dihalogenated aliphatic or alicyclic hydrocarbon of the formulaX--R--CH.sub.2 --X.sub.1where X and X.sub.1 are chloro, bromo or iodo and R is a divalent aliphatic, alicyclic or aralkyl hydrocarbon group,In an aqueous medium in the presence of a phase transfer catalyst.Type: GrantFiled: February 4, 1974Date of Patent: March 2, 1976Assignee: Michigan Chemical CorporationInventor: Robert Phillip Johnson