Abstract: .alpha.-[10-oxy-4H-benzo[4,5]cycloheptal[1,2-b]thiophen-4-ylidene]-carboxyl ic acids, or physiologically-hydrolysable and -acceptable esters or pharmaceutically acceptable salts thereof are useful for effecting monokine inhibition, in particular interleukin-1 release or secretion inhibition, as a therapeutic means other than anti-inflammatory or anti-pyretic means.
Type:
Grant
Filed:
October 25, 1988
Date of Patent:
September 11, 1990
Assignee:
Sandoz Ltd.
Inventors:
Pietro Bollinger, Hans U. Gubler, Jorg Schnyder