Patents Represented by Attorney Robert T. Hrubiec

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  • Substituted thioacetamides
    Patent number: 6919367
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: July 19, 2005
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Preparations of a sulfinyl acetamide
    Patent number: 6875893
    Abstract: The present invention provides processes for the preparation of modafinil which includes the step of reacting benzhydrylthiol and chloroacetamide.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: April 5, 2005
    Assignee: Cephalon, Inc.
    Inventors: Denis Largeau, Gilles Oddon
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 6872746
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: March 29, 2005
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Heterocyclic substituted pyrazolones
    Patent number: 6831075
    Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: December 14, 2004
    Assignee: Cephalon, Inc.
    Inventors: Jasbir Singh, Rabindranath Tripathy
  • Substituted thioacetamides
    Patent number: 6670358
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 30, 2003
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Particle-forming compositions containing fused pyrrolocarbazoles
    Patent number: 6660729
    Abstract: A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: December 9, 2003
    Assignee: Cephalon, Inc.
    Inventors: David A. Dickason, Piyush R. Patel, Vincent Corvari, Efraim Shek, Joseph L. Herman, Jeffry M. Skell
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 6635669
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: October 21, 2003
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Selected fused pyrrolocarbazoles
    Patent number: 6630500
    Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: October 7, 2003
    Assignee: Cephalon, Inc.
    Inventors: Diane E. Gingrich, Robert L. Hudkins
  • Substituted thioacetamides
    Patent number: 6492396
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: December 10, 2002
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Jeffry L. Vaught, Matthew S. Miller
  • Pharmaceutical solutions of modafinil compounds
    Patent number: 6489363
    Abstract: Pharmaceutical compositions of modafinil compounds, and pharmaceutical, non-aqueous compositions of modafinil compounds in organic solvents are disclosed, along with their use in the treatment of diseases.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: December 3, 2002
    Assignee: Cephalon, Inc.
    Inventors: Martin J. Jacobs, Bradley T. McIntyre, Piyush R. Patel
  • Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
    Patent number: 6488164
    Abstract: Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the tuberomamillary neurons of the posterior hypothalamus, and thus exhibits activity in an area of the brain associated with normal wakefulness functions.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: December 3, 2002
    Assignee: Cephalon, Inc.
    Inventors: Matthew S. Miller, Thomas E. Scammell
  • Heterocyclic substituted pyrazolones
    Patent number: 6455525
    Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 24, 2002
    Assignee: Cephalon, Inc.
    Inventors: Jasbir Singh, Rabindranath Tripathy
  • Compositions including modafinil for treatment of eating disorders and for appetite stimulation
    Patent number: 6455588
    Abstract: Modafinil is effective in improving symptoms of eating disorders or in stimulating appetite.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: September 24, 2002
    Assignee: Cephalon, Inc.
    Inventors: Thomas E. Scammell, Matthew S. Miller
  • Isomeric fused pyrrolocarbazoles and isoindolones
    Patent number: 6399780
    Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: June 4, 2002
    Assignee: Cephalon, Inc.
    Inventor: Robert L. Hudkins
  • Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
    Patent number: 6346548
    Abstract: Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the tuberomamillary neurons of the posterior hypothalamus, and thus exhibits activity in an area of the brain associated with normal wakefulness functions.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: February 12, 2002
    Assignee: Cephalon, Inc.
    Inventors: Matthew S. Miller, Thomas E. Scammell
  • Cell-targeting molecule comprising a mutant human carboxypeptidase A
    Patent number: 6140100
    Abstract: Conjugates of a cell targetting molecule and a mutant human carboxypeptidase A enzyme are provided. Suitable targetting molecules include antibodies, hormones, ligands, cytokines, antigens, oligonucleotides and peptidomimetics. Enzymes comprising a mutant human carboxypeptidase A enzyme are also provided.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: October 31, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Gary Keith Smith, Todd Andrew Blumenkopf, Michael Cory
  • Peptides and compounds that bind to the thrombopoietin receptor
    Patent number: 5932546
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: August 3, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Steven E. Cwirla, Sherril S. Johnson, Nicholas C. Wrighton, David J. Duffin, Christopher R. Wagstrom
  • Hypolipidemic 1,4-benzothiazepine-1,1-dioxides
    Patent number: 5910494
    Abstract: The invention is concerned with novel hypolipidemic compounds of formula (I), with processes and novel intermedites for their preparation, pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as atherosclerosis.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: June 8, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventor: Lawrence Edward Brieaddy
  • Peptides and compounds that bind to a receptor
    Patent number: 5869451
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: February 9, 1999
    Assignee: Glaxo Group Limited
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randoph B. DePrince, Surekha Podduturi, Qun Yin
  • Acetamide derivative having defined particle size
    Patent number: RE37516
    Abstract: Pharmaceutical compositions comprising modafinil in the form of particles of defined size. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: January 15, 2002
    Assignee: Cephalon, Inc.
    Inventors: Peter E. Grebow, Vincent Corvari, David Stong