Abstract: MGDF analogs having one or more changed glycosylation sites as compared to a naturally occurring MGDF sequence of a corresponding number of amino acids are disclosed. The invention also relates to DNA sequences encoding said MGDF analogs, recombinant plasmids and host cells for analog expression, and therapeutic compositions including such analogs.
Abstract: The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.
Type:
Grant
Filed:
October 10, 2002
Date of Patent:
February 19, 2008
Assignee:
Amgen Inc.
Inventors:
Hosung Min, Karen C. Sitney, Cynthia Hartley