Patents Represented by Attorney, Agent or Law Firm Robert W. Sprague
  • Di-t-butylphenyl alkyl and benzyl ether nitriles
    Patent number: 4973731
    Abstract: Novel compounds which are di-t-butylphenyl alkyl or benzyl ethers which alkyl or benzyl group is substituted by an acidic group are useful an antiallergic agents. Synthetic intermediates for making such compounds are also disclosed.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: November 27, 1990
    Assignee: Riker Laboratories, Inc.
    Inventor: Mark A. Rustad
  • Substituted di-t-butylphenols and anti-allergic use thereof
    Patent number: 4968710
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: November 6, 1990
    Assignee: Riker Laboratories, Inc.
    Inventor: Mark A. Rustad
  • Antiarrhythmic substituted N-(2-piperidylmethyl)benzamides
    Patent number: 4952574
    Abstract: Certain 2,5-disubstituted N-(2-piperidylmethyl)benzamides, wherein one substituent is 2,2,2-trifluoroethyoxy, and pharmaceutically acceptable acid-addition salts thereof, are active as antiarrhythmic agents.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: August 28, 1990
    Assignee: Riker Laboratories, Inc.
    Inventor: Elden H. Banitt
  • Controlled release flecainide acetate formulation
    Patent number: 4938966
    Abstract: Controlled release pharmaceutical formulations containing flecainide acetate and methods of suppressing arrhythmia using the formulations are described.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: July 3, 1990
    Assignee: Riker Laboratories, Inc.
    Inventors: David Porter, Andrew M. Twitchell
  • Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
    Patent number: 4929624
    Abstract: Novel 1-substituted 1H-imidazo-[4,5-c]quinolin-4-amines are disclosed. These compounds function as antiviral agents, and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: May 29, 1990
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Roy T. Knafla
  • Compressible ear tip
    Patent number: 4913259
    Abstract: An ear tip for use with a stethoscope, audio headset or like device, the ear tip being of a construction and design that provides substantial deformation of the ear tip under normal stethoscope pressures such that in use the ear tip is seated comfortably and conformably against the ear canal opening.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: April 3, 1990
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Thomas J. Packard
  • Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-ca rboxylic acid
    Patent number: 4898945
    Abstract: A process for preparing 6,7-dihydro-9-fluoro-5,8-dimethyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carb oxylic acid, an antimicrobial, using 6-fluoro-2-methylquinoline as a starting material. A synthetic intermediate is also disclosed.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: February 6, 1990
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Bruce E. Williams
  • Organic fluoride sources
    Patent number: 4871786
    Abstract: Organic fluoride sources comprising a tetrafluoroborate salt and capable of releasing fluoride ions into dentition in order to provide inhibition and/or prevention of dental caries are disclosed. A method of releasing fluoride ion into dental tissue is also disclosed.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: October 3, 1989
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Steven M. Aasen, Joel D. Oxman, F. Andrew Ubel, III
  • Compressible ear tip
    Patent number: 4852684
    Abstract: An ear tip for use with a stethoscope, audio headset or like device, the ear tip being of a construction and design that provides substantial deformation of the ear tip under normal stethoscope pressures such that in use the ear tip is seated comfortably and conformably against the ear canal opening.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: August 1, 1989
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Thomas J. Packard
  • Aerosol device
    Patent number: 4834083
    Abstract: The invention is a dispenser for use with aerosol formulations for inhalation therapy. The dispenser is small, conveniently carried, and features means to prevent unintended actuation of the aerosol canister and means to prevent dust and dirt from entering the dispenser during storage.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: May 30, 1989
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: David C. Byram, Gerald W. Teiken, Ralph D. Whaley
  • Anti-glaucoma use of trifluoromethanesulfonamide
    Patent number: 4824866
    Abstract: Trifluoromethanesulfonamide and salts thereof are active as antiglaucoma agent and may be administered topically to the eye. Pharmaceutical formulations of such compounds are also described.
    Type: Grant
    Filed: February 2, 1987
    Date of Patent: April 25, 1989
    Assignee: Riker Laboratories, Inc.
    Inventor: Donald C. Kvam
  • Multi-step process for producing 5-hydroxy-N-(6-oxo-piperidyl-methyl)-2-(2,2,2-trifluoro-ethoxy)-benzamid e and derivatives
    Patent number: 4824953
    Abstract: Certain substituted pyridine compounds are useful synthetic intermediates for preparing compounds of pharmaceutical interest. A synthetic process for using these intermediates is also described.
    Type: Grant
    Filed: February 3, 1987
    Date of Patent: April 25, 1989
    Assignee: Riker Laboratories, Inc.
    Inventor: William R. Bronn
  • Cyclopentanone derivatives
    Patent number: 4822885
    Abstract: Certain substituted cyclopentanone ethylene ketal compounds, and ketones and amides derived therefrom are useful synthetic intermediates for compounds of pharmaceutical interest. A synthetic process for using the intermediates is also described.
    Type: Grant
    Filed: May 3, 1988
    Date of Patent: April 18, 1989
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Elden H. Banitt
  • Drug-containing chlorofluorocarbon aerosol propellent formulations
    Patent number: 4814161
    Abstract: Complete dissolution of a wide range of drugs in chlorofluorocarbon aerosol propellents is achieved by the presence of glycerol phosphatides, preferably phosphatidylcholine.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: March 21, 1989
    Assignee: Riker Laboratories, Inc.
    Inventors: Philip A. Jinks, Alexander Bell, Franz X. Fischer
  • Physically modified beclomethasone dipropionate suitable for use in aerosols
    Patent number: 4810488
    Abstract: A method for preparing a stable aerosol formulation of beclomethasone dipropionate in which the steroid is contacted with an alcohol containing 1 to 5 carbon atoms to form a crystalline solvate therewith, the crystalline material so formed being reduced to a particle size below 10 microns and thereafter dispersed in a composition comprising chlorofluorocarbon propellents.
    Type: Grant
    Filed: August 18, 1986
    Date of Patent: March 7, 1989
    Assignee: Riker Laboratories, Inc.
    Inventor: Philip A. Jinks
  • Transdermal nitroglycerin delivery system
    Patent number: 4751087
    Abstract: A pressure-sensitive adhesive tape for delivering nitroglycerin to skin, the tape comprising a backing with a layer of inert pressure-sensitive adhesive attached thereto, said pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive polymer, skin penetration-enhancing ingredients and a relatively high concentration of nitroglycerin. The tape is useful for systemic treatment of angina pectoris, control of hypertension and treatment of congestive heart failure.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: June 14, 1988
    Assignee: Riker Laboratories, Inc.
    Inventor: Steven M. Wick
  • Topical antiinflammatory compositions
    Patent number: 4738842
    Abstract: Novel topical creams or lotions containing 2,6-di-t-butyl-4-(2'-thenoyl)phenol exhibiting good skin penetrability are disclosed.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: April 19, 1988
    Assignee: Riker Laboratories
    Inventors: Gordon J. Dow, Helen J. Schultz
  • Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
    Patent number: 4734413
    Abstract: Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators are disclosed. Pharmaceutical formulations comprising such compounds and pharmacological methods of using such compounds are also described.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: March 29, 1988
    Assignee: Riker Laboratories, Inc.
    Inventor: James J. Wade
  • Substituted di-t-butylphenols
    Patent number: 4716178
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a group which includes carboxyl, tetrazolyl or N-methyltetrazolyl are useful as inhibitors of leukotriene synthesis and as antiallergic agents. Pharmaceutical compositions containing such compounds and pharmacological methods for use of such compounds are also disclosed.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: December 29, 1987
    Assignee: Riker Laboratories, Inc.
    Inventors: Robert A. Scherrer, Mark A. Rustad
  • Antiallergic agents
    Patent number: 4714776
    Abstract: Novel antiallergic agents are described which are carboxy-substituted 3,5-di(tertiary-butyl)-4-hydroxybenzophenones. Pharmaceutical compositions containing and pharmacological methods for using such compounds are also described, as are synthetic intermediates for preparing such compounds.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: December 22, 1987
    Assignee: Riker Laboratories, Inc.
    Inventors: Randy L. Bell, George G. I. Moore