Patents Represented by Attorney Robert Wiser

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  • Oral vaccines
    Patent number: 4920209
    Abstract: Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.
    Type: Grant
    Filed: June 4, 1987
    Date of Patent: April 24, 1990
    Assignee: American Home Products Corporation
    Inventors: Alan R. Davis, Paul P. Hung
  • Analgesic pentapeptides
    Patent number: 4278596
    Abstract: Pentapeptides of the formula: ##STR1## wherein R.sup.1 is hydrogen, methyl, ethyl, propyl, 2-methyl-2-pentenyl, 2-methyl-1-pentenyl, cyclopropylmethyl, or cyclobutylmethyl; R.sup.2, R.sup.3, and R.sup.4 are, independently, hydrogen or methyl; and X is --OH, --NH.sub.2, --NHC.sub.n H.sub.2n+1 where n is 1, 2, 3, or 4, --OR.sup.3, or CH.sub.2 OR.sup.3, where R.sup.3 is hydrogen or lower alkyl of from 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof; have analgesic activity upon administration to warm-blooded animals.
    Type: Grant
    Filed: August 8, 1978
    Date of Patent: July 14, 1981
    Assignee: American Home Products Corporation
    Inventor: Victor M. Garsky
  • Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response
    Patent number: 4214089
    Abstract: The use of 3-aryl-thiazolo[3,2-a]benzimidazoles, 3-aryl-imidazo[2,1-b]thiazoles, and related compounds as antineoplastic agents, and/or as enhancers of the immune response is disclosed.
    Type: Grant
    Filed: July 18, 1978
    Date of Patent: July 22, 1980
    Assignee: American Home Products Corporation
    Inventors: Richard L. Fenichel, Peter H. L. Wei, Francis J. Gregory, Harvey E. Alburn
  • Dipeptide narcotic antagonists
    Patent number: 4205069
    Abstract: Novel dipeptides of the formula: A--X--Y--B wherein X is D-Tyr or L-Tyr; Y is D-Ala, L-Ala, D-Ser, L-Ser, or Gly; with the proviso that at least one of X and Y is of the D- configuration; A is hydrogen, allyl, or lower alkyl of 1 to 3 carbon atoms; B is --NH.sub.2, --OMe, or --NHNH.sub.2 ; and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions containing them, and a process for antagonizing the effects of a narcotic analgesic agent in warm blooded animals are disclosed.
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: May 27, 1980
    Assignee: American Home Products Corporation
    Inventors: James D. Beluzzi, William H. McGregor, Larry Stein
  • Benzylamine analgesics
    Patent number: 4155935
    Abstract: Reaction of benzalcyclanones with secondary amines affords aminobenzylcyclohexanones, which, upon reduction, yield aminobenzylcyclohexanols having potent analgesic activity. Epimeric aminobenzylcycloalkanols having analgesic activity are prepared by the reaction of C-phenyl nitrones with cycloalkenes to form benzisoxazoles, treatment with alkyl halide to form the corresponding benzisoxazolium halides, followed by hydrogenolysis.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: May 22, 1979
    Assignee: American Home Products Corporation
    Inventors: John P. Yardley, Peter B. Russell
  • Prostaglandin derivatives
    Patent number: 4151361
    Abstract: Derivatives of 13,14-dihydro-PGE.sub.2 and 5,6; 13,14-tetrahydro-PGE.sub.2 are prepared. These new compounds not heretofore found in nature display activity as bronchodilator agents.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: April 24, 1979
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • Prostaglandin derivatives
    Patent number: 4138590
    Abstract: Derivatives of PGD.sub.2 are prepared. These new compounds not heretofore found in nature display pharmacological activity, for example, inhibition of blood platelet aggregation.
    Type: Grant
    Filed: January 13, 1977
    Date of Patent: February 6, 1979
    Assignee: American Home Products Corporation
    Inventor: Wenling Kao
  • Cyclic undecapeptides related to somatostatin and intermediates therefor
    Patent number: 4133805
    Abstract: Cyclic undecapeptides of the general formula ##STR1## WHEREIN N IS AN INTEGER OF FROM 3 TO 8 AND T may be either L-Trp or D-Trp are disclosed. These compounds inhibit the release of pituitary growth hormome, glucagon, and insulin.
    Type: Grant
    Filed: December 16, 1975
    Date of Patent: January 9, 1979
    Assignee: American Home Products Corporation
    Inventor: John P. Yardley
  • Somatostatin analogs
    Patent number: 4122077
    Abstract: Somatostatin analogs which contain certain D-amino acid residues are disclosed. These analogs contain, in addition to a D-Trp.sup.8 residue, glycyl or D-amino acid residues in positions 4 and 5.These compounds inhibit the release of pituitary growth hormone, glucagon, and insulin.
    Type: Grant
    Filed: December 13, 1977
    Date of Patent: October 24, 1978
    Assignee: American Home Products Corporation
    Inventor: Dimitrios Sarantakis
  • Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine
    Patent number: 4097596
    Abstract: The use of quaternary salts of promethazine by the inhalation route is described. The thus administered compositions provide new, non-toxic, potent means for relieving bronchial spasm and bronchoconstriction in warm-blooded animals.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: June 27, 1978
    Assignee: American Home Products Corporation
    Inventors: Albert J. Begany, Marvin E. Rosenthale, Alphonse Dervinis
  • 15-Substituted prostanoic acids
    Patent number: 4091015
    Abstract: 9-Oxo-15-Substituted prostanoic acids, and intermediates for their preparation are disclosed. The final products have bronchodilatory activity.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: May 23, 1978
    Assignee: American Home Products Corporation
    Inventor: Donald P. Strike
  • Prostaglandin derivatives
    Patent number: 4089885
    Abstract: Derivatives of 13,14-dihydro-PGE.sub.2 and 5,6; 13,14-tetrahydro-PGE.sub.2 are prepared. These new compounds not heretofore found in nature display activity as bronchodilator agents.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: May 16, 1978
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • 11-Deoxy-15-substituted prostaglandins
    Patent number: 4086269
    Abstract: Processes for the total synthesis of dl-11-deoxy-15-substituted prostaglandins, novel intermediates therefore, certain novel final products, as well as optical resolutions of the final products are disclosed.The final products are bronchodilators.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: April 25, 1978
    Assignee: American Home Products Corporation
    Inventors: Donald P. Strike, Wenling Kao
  • Somatostatin analogs
    Patent number: 4077952
    Abstract: Somatostatin analogs which contain L-Arg.sup.4 -L-His.sup.5 amino acids residues in place of the normally present L-Lys.sup.4 -L-Asn.sup.5 residues are disclosed. Other modifications of somatostatin are also disclosed.These compounds inhibit the release of pituitary growth hormone, glucagon, and insulin.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: March 7, 1978
    Assignee: American Home Products Corporation
    Inventor: Dimitrios Sarantakis
  • Process for enhancing the production of enterotoxin by Vibrio cholerae
    Patent number: 4076590
    Abstract: A process for increasing the production of enterotoxin by Vibrio cholerae, and enterotoxigenic strains of Escherichia coli, is disclosed. This process produces enhanced amounts of enterotoxin activity compared to amounts obtainable by practice of standard procedures.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: February 28, 1978
    Assignee: American Home Products Corporation
    Inventor: Mark H. Levner
  • 1,3-Bridged amino tetralins
    Patent number: 4076953
    Abstract: 1,3-Bridged-2-amino tetralins, having spiro substitution or the bridge, and intermediates thereto. The final products have analgesic activity.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: February 28, 1978
    Assignee: American Home Products Corporation
    Inventors: Meier E. Freed, John R. Potoski
  • 15-Ethynyl-PGE.sub.1
    Patent number: 4064165
    Abstract: 7-(2.beta.-[(3S)-3-Ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-ox o-1.alpha.-cyclopentyl)-cis-5-heptenoic acid, 2.beta.-[(3S)-3-ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-oxo- 1.alpha.-cyclopentane heptanoic acid, related compounds, and intermediates thereto are disclosed. The final products have activity as bronchodilators and in reducing gastric secretion.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: December 20, 1977
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • 15-Ethynyl substituted prostanoic acids
    Patent number: 4062783
    Abstract: 9-Oxo-15-substituted prostanoic acids, and intermediates for their preparation and for the preparation of other known prostaglandins are disclosed. The final products have bronchodilatory activity.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: December 13, 1977
    Assignee: American Home Products Corporation
    Inventor: Donald P. Strike
  • 2,3-Dialkoxy-3H-1,4-benzodiazepines
    Patent number: 4056525
    Abstract: 2,3-Dialkoxy-3H-1,4-benzodiazepines which have CNS depressant activity.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: November 1, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Daniel M. Teller
  • Prostaglandin derivatives
    Patent number: 4053467
    Abstract: Prostaglandin compounds substituted at the 11-position with a methyl group are prepared from PGA.sub.2, its 15-epimer, and their esters. These compounds, not heretofore found in nature, possess a variety of pharmacological activities one of which is bronchodilation.
    Type: Grant
    Filed: July 25, 1974
    Date of Patent: October 11, 1977
    Assignee: American Home Products Corporation
    Inventors: Wenling Kao, Donald P. Strike