Patents Represented by Attorney, Agent or Law Firm Roberta P. Saxon
-
Patent number: 6949568Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: August 18, 2003Date of Patent: September 27, 2005Assignee: Theravance, Inc.Inventors: Edmund J. Moran, John R. Jacobsen, James Aggen
-
Patent number: 6916961Abstract: Disclosed are multibinding compounds which are ?2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: March 28, 2002Date of Patent: July 12, 2005Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6815555Abstract: The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or sedation in a mammal using substituted phenol compounds.Type: GrantFiled: September 26, 2002Date of Patent: November 9, 2004Assignee: Theravance, Inc.Inventors: Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu, Jennifer Bolton
-
Patent number: 6770621Abstract: Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.Type: GrantFiled: May 1, 2001Date of Patent: August 3, 2004Assignee: Theravance, Inc.Inventors: Martin S. Linsell, J. Kevin Judice
-
Patent number: 6756400Abstract: The invention provides sodium channel modulating compounds of formula I: wherein X, Y, Q, R1, w, and R2 have any of the values defined in the specification, and salts thereof, which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).Type: GrantFiled: August 30, 2001Date of Patent: June 29, 2004Assignee: Theravance, Inc.Inventors: Jason P. Chinn, Seok-Ki Choi, Paul R. Fatheree, Daniel Marquess, S. Derek Turner
-
Patent number: 6750241Abstract: Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or more linking groups. Such compounds are useful for treating diseases or medical disorders mediated by protein kinases.Type: GrantFiled: March 6, 2002Date of Patent: June 15, 2004Assignee: Theravance, Inc.Inventors: John H. Griffin, Yu-Hua Ji, Edmund J. Moran, Jonathan W. Wray
-
Patent number: 6713651Abstract: Disclosed are multibinding compounds which are &bgr;2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: November 1, 2000Date of Patent: March 30, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6686362Abstract: Compounds of formula (I) in which R1, R2, R3 and R4 have the meanings given in the specification, are receptor tyrosine kinase inhibitors useful in the treatment of proliferative disorders, such as cancer.Type: GrantFiled: December 20, 2002Date of Patent: February 3, 2004Assignee: Theravance, Inc.Inventors: John H. Griffin, Roger Briesewitz, Jonathan W. Wray
-
Patent number: 6683115Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: August 21, 2001Date of Patent: January 27, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6670376Abstract: The invention provides novel &bgr;2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with &bgr;2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: November 12, 2002Date of Patent: December 30, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, John R. Jacobsen, Michael R. Leadbetter, Matthew B. Nodwell, Sean G. Trapp, James Aggen, Timothy J. Church
-
Patent number: 6653323Abstract: The invention provides novel &bgr;2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with &bgr;2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: November 12, 2002Date of Patent: November 25, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, John R. Jacobsen, James B. Aggen
-
Patent number: 6646012Abstract: The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).Type: GrantFiled: January 15, 2002Date of Patent: November 11, 2003Assignee: Theravance, Inc.Inventors: Seok-Ki Choi, Paul R. Fatheree, David C. Green, Daniel Marquess
-
Patent number: 6613972Abstract: A generally toroidal counterflow heat exchanger is the main element of a combustor that operates at a micro scale. The combustor includes a central combustion region with openings to a reactant gas channel and an exhaust gas channel. The reactant channel and exhaust channels are coiled around each other in a spiral configuration that reduces heat loss. An electric current microgenerator is similar and also includes a thermoelectric active wall composed of n-type and p-type thermoelectric elements as part of a channel wall of the microcombustor. The thermoelectric active wall includes fins configured to increase the temperature differential across the thermoelectric elements relative to the temperature difference between the thermoelectric elements and the reactant and exhaust gases. A method of monolithically fabricating such microdevices by electrodepositing multiple layers of material is also provided.Type: GrantFiled: January 5, 2001Date of Patent: September 2, 2003Assignee: University of Southern CaliforniaInventors: Adam L. Cohen, Paul Ronney, Uri Frodis, Lars Sitzki, Eckart Meiburg, Steffen Wussow
-
Patent number: 6593497Abstract: The present invention is directed to multibinding compounds which are &bgr;2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: February 14, 2000Date of Patent: July 15, 2003Assignee: Theravance, Inc.Inventors: Seok-Ki Choi, Edmund J. Moran
-
Patent number: 6576793Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: August 14, 2000Date of Patent: June 10, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, John H. Griffin, Seok-Ki Choi
-
Patent number: 6576791Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.Type: GrantFiled: October 3, 2000Date of Patent: June 10, 2003Assignee: Theravance, Inc.Inventors: Sabine M. Axt, Timothy J. Church, Witold N. Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
-
Patent number: 6541669Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: June 2, 1999Date of Patent: April 1, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6479498Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.Type: GrantFiled: November 9, 2001Date of Patent: November 12, 2002Assignee: Theravance, Inc.Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins, David C. Green
-
Patent number: 6420560Abstract: This invention relates to novel multibinding compounds (agents) that are H1 histamine receptor antagonists and pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions of this invention are useful in the treatment and prevention of allergic diseases such as rhinitis, urticaria, asthma, and anaphylaxis, and the like.Type: GrantFiled: June 7, 1999Date of Patent: July 16, 2002Assignee: Theravance, Inc.Inventors: Robert P. Numerof, Yu-Hua Ji, John H. Griffin
-
Patent number: 6420354Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.Type: GrantFiled: December 8, 1999Date of Patent: July 16, 2002Assignee: Advanced Medicine, Inc.Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins