Patents Represented by Attorney, Agent or Law Firm Robin M. Silva
  • Fc variants with altered binding to FcRn
    Patent number: 8088376
    Abstract: The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: January 3, 2012
    Assignee: Xencor, Inc.
    Inventors: Aaron Keith Chamberlain, Bassil I. Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
  • TNF-?variants
    Patent number: 7101974
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 5, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Nucleic acids and proteins with thioredoxin reductase activity
    Patent number: 7071307
    Abstract: The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: July 4, 2006
    Assignees: Syngenta Participations AG, Xencor, Inc.
    Inventors: Bipin K. Dalmia, Steven P. Briggs, Greg del Val, John R. Desjarlais, Peter Heifetz, Peter Luginbuhl, Umesh Muchhal
  • TNF-? variants
    Patent number: 7056695
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 6, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Tissue collection devices containing biosensors
    Patent number: 6833267
    Abstract: The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and enzymes.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: December 21, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Method to prevent graft rejection using TGF-beta to induce T suppressor cells
    Patent number: 6759035
    Abstract: The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: July 6, 2004
    Assignee: University of Southen California
    Inventor: David A. Horwitz
  • Proteins with insulin-like activity useful in the treatment of diabetes
    Patent number: 6746853
    Abstract: The invention relates to novel insulin activity (IA) proteins and nucleic acids. The Invention further relates to the use of the IA proteins in the treatment of insulin related disorders such as type 1 diabetes and type 2 diabetes.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 8, 2004
    Assignee: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Andrew G. Morton
  • Fluorescent dye binding peptides
    Patent number: 6747135
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 8, 2004
    Assignee: The Board of Trustees for the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Signal detection techniques for the detection of analytes
    Patent number: 6740518
    Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: May 25, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
  • Magnetic resonance imaging agents for the delivery of therapeutic agents
    Patent number: 6713046
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies
    Inventor: Thomas J. Meade
  • Targeted magnetic resonance imaging agents for the detection of physiological processes
    Patent number: 6713045
    Abstract: The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Thomas Meade, Scott Fraser, Russell Jacobs
  • Apparatus and method for automated protein design
    Patent number: 6708120
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 16, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Amplification of nucleic acids with electronic detection
    Patent number: 6686150
    Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 3, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Bruce D. Irvine, Jon Faiz Kayyem, Edward Lewis Sheldon, III, Robert H. Terbrueggen
  • Thermostable alkaliphilic xylanase
    Patent number: 6682923
    Abstract: The invention relates to novel xylanase activity (XA) proteins and nucleic acids. The invention further relates to the use of the XA proteins in the process of pulp bleaching.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 27, 2004
    Assignee: Xencor
    Inventors: Jörg Bentzien, Bassil I. Dahiyat
  • Functional MRI agents for cancer imaging
    Patent number: 6673333
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents for imaging cancer.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: January 6, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Thomas J. Meade, Scott Fraser, Russell Jacobs
  • Optical fiber biosensor array comprising cell populations confined to microcavities
    Patent number: 6667159
    Abstract: A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and biological materials, are deployed in a plurality of microwells formed at the distal end of individual fibers within a fiber optic array. The biosensor array utilizes an optically interrogatable encoding scheme for determining the identity and location of each cell type in the array and provides for simultaneous measurements of large numbers of individual cell responses to target analytes. The sensing method utilizes the unique ability of cell populations to respond to biologically significant compounds in a characteristic and detectable manner. The biosensor array and measurement method may be employed in the study of biologically active materials, in situ environmental monitoring, monitoring of a variety of bioprocesses, and for high throughput screening of large combinatorial chemical libraries.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: December 23, 2003
    Assignee: Trustees of Tufts College
    Inventors: David R. Walt, Laura Taylor
  • Macrocyclic magnetic resonance imaging contrast agents
    Patent number: 6656450
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: December 2, 2003
    Assignee: California Institute of Technology, Inc.
    Inventors: Timothy J. Hubin, Thomas J. Meade
  • Method and apparatus for performing biological reactions on a substrate surface
    Patent number: 6642046
    Abstract: The present invention provides methods and apparatus for performing biological reactions on a substrate surface that use a low volume of sample fluid, accommodate substrates as large as or larger than a conventional microscope slide, accommodate a plurality of independent reactions, and accommodate a substrate surface having one or more hydrogel-based microarrays attached thereto. The invention further provides an apparatus that allows introduction of fluids in addition to sample fluid into each reaction chamber via standard pipet tips and associated pipettor apparatus. The invention further an apparatus that increases reaction reproducibility, increases reaction efficiency, and reduces reaction duration.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: November 4, 2003
    Assignee: Motorola, Inc.
    Inventors: Mark W. McGarry, Peter Kahn, Todd Tuggle, George Hawkins
  • Nucleic acids and protein variants of hG-CSF with granulopoietic activity
    Patent number: 6627186
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: September 30, 2003
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Method for enhanced bio-conjugation events
    Patent number: 6602400
    Abstract: The present invention provides an apparatus and methods for efficient, high-throughput electrical or electrochemical detection of biomolecules. More specifically, the invention provides an apparatus in which an independent set of electrodes is used to increase the occurrence of a desired bio-conjugation event at a test site.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: August 5, 2003
    Assignee: Motorola, Inc.
    Inventors: Vi-En Choong, Changming Li, Song Shi, George Maracas