Patents Represented by Attorney, Agent or Law Firm Robin M. Silva
  • Optimized Fc variants and methods for their generation
    Patent number: 8093357
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: January 10, 2012
    Assignee: Xencor, Inc.
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Fc variants with altered binding to FcRn
    Patent number: 8088376
    Abstract: The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: January 3, 2012
    Assignee: Xencor, Inc.
    Inventors: Aaron Keith Chamberlain, Bassil I. Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
  • TNF-?variants
    Patent number: 7101974
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 5, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Nucleic acids and proteins with thioredoxin reductase activity
    Patent number: 7071307
    Abstract: The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: July 4, 2006
    Assignees: Syngenta Participations AG, Xencor, Inc.
    Inventors: Bipin K. Dalmia, Steven P. Briggs, Greg del Val, John R. Desjarlais, Peter Heifetz, Peter Luginbuhl, Umesh Muchhal
  • TNF-? variants
    Patent number: 7056695
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 6, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • Tissue collection devices containing biosensors
    Patent number: 6833267
    Abstract: The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and enzymes.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: December 21, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Protein and peptide sensors using electrical detection methods
    Patent number: 6824669
    Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: November 30, 2004
    Assignee: Motorola, Inc.
    Inventors: Changming Li, Jaymie Robin Sawyer, Vi-En Choong, George Maracas, Peiming Zhang
  • Apparatus and method for automated protein design
    Patent number: 6804611
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 12, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Apparatus and method for automated protein design
    Patent number: 6801861
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: October 5, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Apparatus and method for automated protein design
    Patent number: 6792356
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: September 14, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Magnetic resonance imaging agents for the detection of physiological agents
    Patent number: 6770261
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: August 3, 2004
    Assignee: Research Corporation Technologies
    Inventors: Thomas J. Meade, Scott Fraser
  • Printed circuit boards with monolayers and capture ligands
    Patent number: 6761816
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: July 13, 2004
    Assignee: Clinical Micro Systems, Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Method to prevent graft rejection using TGF-beta to induce T suppressor cells
    Patent number: 6759035
    Abstract: The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: July 6, 2004
    Assignee: University of Southen California
    Inventor: David A. Horwitz
  • Target analyte detection using asymmetrical self-assembled monolayers
    Patent number: 6753143
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chunlin Tao, Changjun Yu
  • Fluorescent dye binding peptides
    Patent number: 6747135
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 8, 2004
    Assignee: The Board of Trustees for the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Proteins with insulin-like activity useful in the treatment of diabetes
    Patent number: 6746853
    Abstract: The invention relates to novel insulin activity (IA) proteins and nucleic acids. The Invention further relates to the use of the IA proteins in the treatment of insulin related disorders such as type 1 diabetes and type 2 diabetes.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 8, 2004
    Assignee: Xencor, Inc.
    Inventors: Bassil I. Dahiyat, Andrew G. Morton
  • Signal detection techniques for the detection of analytes
    Patent number: 6740518
    Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: May 25, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
  • Targeted magnetic resonance imaging agents for the detection of physiological processes
    Patent number: 6713045
    Abstract: The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Thomas Meade, Scott Fraser, Russell Jacobs
  • Magnetic resonance imaging agents for the delivery of therapeutic agents
    Patent number: 6713046
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents and methods of delivering therapeutically active agents.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: March 30, 2004
    Assignee: Research Corporation Technologies
    Inventor: Thomas J. Meade
  • Apparatus and method for automated protein design
    Patent number: 6708120
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 16, 2004
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street