Patents Represented by Attorney, Agent or Law Firm Robin Teskin
  • G&agr;q protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
    Patent number: 6818747
    Abstract: The invention provides a series of G&agr;q protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the G&agr;q protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: November 16, 2004
    Assignee: Senomyx, Inc.
    Inventors: Yong Yao, Hong Xu
  • Estrogen receptor modulators
    Patent number: 6291505
    Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: September 18, 2001
    Assignee: Chiron Corporation
    Inventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
  • Expression of urokinase plasminogen activator inhibitors
    Patent number: 6268341
    Abstract: Unfucosylated huPAR polypeptides that contains huPA1-48 (SEQ ID NQ:22) are provided. These polypeptides are useful for treating diseases wherein antagonism of huPAR is therapeutically beneficial.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: July 31, 2001
    Assignee: Chiron Corporation
    Inventors: Steven Rosenberg, Jennifer R. Stratton-Thomas