Patents Represented by Attorney, Agent or Law Firm Roche Diagnostics Corporation
  • Patent number: 6787109
    Abstract: Analysis system for the analytical investigation of a sample, in particular of a body fluid. It consists of test elements brought into contact, for performing an analysis, with a sample to be investigated, and an evaluation apparatus with a test element support for positioning the test element in a measurement position, as well as a measurement and evaluation electronic device. The measurement and evaluation electronic device of the evaluation apparatus comprises a temperature correction device, in order to take into account the temperature prevailing in the measurement zone during the measurement for the determination of the result of the analysis. The temperature correction unit includes a temperature history imaging device for the currentless tracing of the temperature history before the time of measuring, without consuming electric energy before the time of measuring.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 7, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Hans-Peter Haar, George B. K. Meacham
  • Patent number: 6783957
    Abstract: The method of polypeptide synthesis in eukaryotic or porkaryotic cell-free systems based on a modified verion of synthesis in the continuous flow or continuous exchange modes when, in addition to input into the reaction mixture of components maintaining the synthesis and removal from the reaction mixture of low molecular weight components inhibiting the synthesis, the concentration of at least one of the components selected from the group consisting of Mg2+, K+, NTP, polyamines or their combinations determining the productivity of the synthesis is continuously changed within the given range of concentrations, while the concentrations of the other components are maintained constant.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: August 31, 2004
    Assignees: Roche Diagnostics GmbH, Institute of Protein Research
    Inventors: Sergey Vladimirovich Biryukov, Peter Nikolaevich Simonenko, Vladimir Anatolievich Shirokov, Alexander Sergeyevich Spirin
  • Patent number: 6720417
    Abstract: A device for isolating nucleic acids which reduces the transfer of contaminants during nucleic acid isolation methods which is composed of two vessels which are linked by a closing element in which a material that binds nucleic acids is placed. The nucleic acid can for example be bound to the material by tipping the device.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: April 13, 2004
    Assignee: Roche Diagnostics GmbH
    Inventor: Thomas Walter
  • Patent number: 6716640
    Abstract: The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: April 6, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Gabriele Punzmann, Martin Egger, Hans-Peter Josel
  • Patent number: 6682704
    Abstract: The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite to one another into which the test elements are inserted in such a way that they lie directly adjacent to one another and the edges of adjacent supports abut one another. A further subject matter of the invention is a system which comprises a slide (14, 31) in addition to the magazine according to the invention which is used to push a layer of test elements along the guide grooves towards the opposite end of the layer to remove test elements from the magazine.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 27, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Gunter Bottwein, Reinhard Bär, Hans List, Friedrich Heid
  • Patent number: 6670173
    Abstract: A bioreaction module for biochemical reactions, in particular for cell-free polypeptide biosynthesis, having a housing (1) including a system chamber (12) and a supply chamber (10), wherein the system chamber (12) contains a producing system during the biochemical reaction and the supply chamber (10) contains a supply liquid during the biochemical reaction, and the system chamber (12) and the supply chamber (10) are separated by a semi-permeable membrane (7). The housing (1) comprises a system chamber element (5) and at least one supply chamber element (3) between which the semi-permeable membrane (7) is mounted in such a manner that the system chamber (12) is defined by the system chamber element (5) and the semi-permeable membrane (7) and the supply chamber (10) is defined by the supply chamber element (3) and the semi-permeable membrane (7).
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: December 30, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans Schels, Horst Menzler, Ulrike Fischer
  • Patent number: 6653456
    Abstract: A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: November 25, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Mitali Ghoshal, Salvatore J. Salamone
  • Patent number: 6645732
    Abstract: The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin G class in the presence of immunoglobulins of the M class in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors, an essential component of R2 being a binding partner in monomeric form, a reagent for determining an antigen-specific antibody of the immunoglobulin G class as well as the use of binding partners in monomeric form for the determination of an antigen-specific antibody of the immunoglobulin G class.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: November 11, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Elke Faatz, Urban Schmitt
  • Patent number: 6635420
    Abstract: The invention concerns a method for the purification of a target substance from a biological sample by immobilizing the target substance on a solid phase by means of a high affinity binding pair and subsequently eluting it by adding a partner of the binding pair in a free form. In addition reagent kits for carrying out the method are disclosed.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: October 21, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang Hosel, Helmut Lenz, Jochen Peter
  • Patent number: 6552199
    Abstract: The subject matter of the invention are new xanthene derivatives of the formula I, wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are—due to their spectral properties (absorption maxima in the range of approx. 650 nm and above as well as emission maxima above 670 nm)—very suitable for the use as dyes and in particular as fluorescence dyes. The compounds of the formula I according to the invention are used for the production of fluorescence conjugates, for their application in immunoassays, for DNA analytics, for in-vivo diagnostics or as a laser dye.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: April 22, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Ewald Daltrozzo, Alexander Reiss
  • Patent number: 6537496
    Abstract: A flat-shaped functional overlay for at least one region of a flat-shaped flexible object which does not form a fold when the sandwich composed of the flexible object and overlay is bent towards the side on which the overlay is located is described. The overlay is composed of one or several flat-shaped overlays which are attached to the flexible object in such a way that a part of their surface can move freely relative to the surface of the object covered by this part in the direction of curvature produced when the object is bent. In addition diagnostic test strips are described which have such an overlay.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: March 25, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang-Reinhold Knappe, Helmut Leininger, Ralf Steinbrueck, Franz Wittmann
  • Patent number: 6534017
    Abstract: The invention concerns a magazine for storing test elements (1) with one or several test zones (3) which are attached adjacent to one another on a rectangular support, wherein the magazine has at least one pair of guide grooves (18a, b) located opposite to one another into which the test elements are inserted in such a way that they lie directly adjacent to one another and the edges of adjacent supports abut one another. A further subject matter of the invention is a system which comprises a slide (14, 31) in addition to the magazine according to the invention which is used to push a layer of test elements along the guide grooves towards the opposite end of the layer to remove test elements from the magazine.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 18, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Gunter Bottwein, Reinhard Bär, Hans List, Friedrich Heid
  • Patent number: 6534325
    Abstract: The present invention provides an immunoassay method for the highly sensitive detection of amphetamines, methamphetamines, and methylenedioxy designer amphetamines in urine samples. Commercially available reagents for the determination of amphetamines and methamphetamines are used with a calibrator comprising a known amount of a substance selected from the group consisting of methylenedioxy designer amphetamines.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: March 18, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Alan J. McNally, Huiru Zhao, Krystyna Goc-Szkutnicka
  • Patent number: 6524808
    Abstract: The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: February 25, 2003
    Assignee: Roche Diagnostics Corporation
    Inventors: Allan R. Dorn, Salvatore J. Salamone, Mitali Ghoshal, Eva Hoess, Erasmus Huber, Ronald C. Hawley, John W. Patterson
  • Patent number: 6518058
    Abstract: The present invention provides a method for synthesis polypeptides in a cell-free system by which products of synthesis are branched in a low molecular weight fraction and a fraction which contains high molecular weight components with the target polypeptide, the main part of the low molecular weight fraction is removed via at least one part of the second porous barrier, the ratio of the volume of the fractions of feed solution and expendable components to the volume of the fraction containing the target polypeptide is chosen, modes of supply of the feed solution and expendable components of the fraction are realized.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: February 11, 2003
    Assignee: Roche Diagnostics GmbH
    Inventors: Sergey Vladimirovich Biryukov, Peter Nikolayevich Simonenko, Vladimir Anatolievich Shirokov, Sergey Gennadievich Mayorov, Alexander Sergeyevich Spirin
  • Patent number: 6489129
    Abstract: The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors wherein an essential component of R2 is a binding partner in a polymeric form and interference by IgG antibodies of the same antigen specificity is reduced by binding partners in a monomeric form; a reagent for determining an antigen-specific antibody of the immunoglobulin M class, as well as the use of binding partners in a monomeric form to reduce interference by IgG antibodies in the determination of antigen-specific IgM antibodies.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: December 3, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Elke Faatz, Urban Schmitt, Beatus Ofenloch-Hahnle
  • Patent number: 6475764
    Abstract: A polypeptide with the properties of collagenase class I from Clostridium histolyticum (CHC I) and the amino acid sequence SEQ ID NO:2 which is optionally N-terminally extended by one or several amino acids of the sequence SEQ ID NO:3 is advantageously suitable for the isolation of cells from mammalian tissue and human tissue.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: November 5, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Helmut Burtscher, Dorothee Ambrosius, Friederike Hesse
  • Patent number: 6455001
    Abstract: A skeleton-free functional layer of high precision which contains a wetting agent of formula I, II and/or III R1—CO—N(R2)—CH2—COOMe  (I) R1—CO—N(R2)—CH2—CH2—SO3Me  (II) HO2C—CH2—CH2—CH(NH—COR1)—CO2Me  (III) in which R1 is a long-chained aliphatic residue, R2 is an alkyl residue with 1 to 8 C atoms and Me represents hydrogen or a metal atom, a diagnostic test strip having this functional layer as well as processes for the production of these objects are described.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: September 24, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Wolfgang-Reinhold Knappe, Dan Mosoiu
  • Patent number: D471280
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Roche Diagnostics Corporation
    Inventor: Thomas Jaeck
  • Patent number: D493536
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: July 27, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Thomas Jaeck, Alexa Nagel, Bernd Eisenbarth, Maria van Gelder, Silke Vogt, James West, Craig Wightman