Patents Represented by Attorney Rogalskyj & Weyand, LLP
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Patent number: 7271148Abstract: The invention provides a method of decreasing viral replication in cells, the method comprising decreasing levels of functional cellular protease in the cells. The invention further provides a method of treating or preventing a viral infection in a subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of functional cellular protease in the cells of the subject.Type: GrantFiled: December 22, 2000Date of Patent: September 18, 2007Assignee: The Board of Regents of The University of Texas SystemInventors: Thomas B. Albrecht, Zhenping Chen
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Patent number: 7223312Abstract: Disclosed is a method of reducing damage resulting from environmental electromagnetic effects on a non-metallic surface. The method includes disposing a polymeric sheet material over the non-metallic surface and disposing a metal layer between the non-metallic surface and the polymeric sheet material. Objects which includes a substrate having a non-metallic surface, a halopolymer sheet material disposed over the substrate's non-metallic surface, and a metal layer disposed between the halopolymer sheet material and the substrate's non-metallic surface are also described. Laminates are also disclosed. One such laminate includes a metal layer having a first surface and a second surface, a halopolymer sheet material bonded or adhered to the first surface of the metal layer, and an adhesive disposed on the second surface of the metal layer.Type: GrantFiled: July 1, 2004Date of Patent: May 29, 2007Assignee: Integument Technologies, Inc.Inventors: Terrence G. Vargo, Timothy S. Koloski
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Patent number: 7217754Abstract: Composites which include a polymer matrix having natural free volume therein and an inorganic or organic material disposed in the natural free volume of the polymer matrix are disclosed. In addition, methods for making a composite are described. A polymer matrix having free volume therein is provided. The free volume is evacuated, and inorganic or organic molecules are infused into the evacuated free volume of the polymer matrix. The inorganic or organic molecules can then be polymerized under conditions effective to cause the polymerized inorganic or organic molecules to assemble into nanoparticles or other types of macromolecular networks. Alternatively, where the polymer matrix contains a functionality, the inorganic or organic molecules can be treated under conditions effective to cause the inorganic or organic molecules to interact with the polymer matrix's functionality.Type: GrantFiled: April 12, 2003Date of Patent: May 15, 2007Assignee: Integument Technologies, Inc.Inventors: Timothy S. Koloski, Terrence G. Vargo
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Patent number: 7205390Abstract: A substantially pure 3-phosphoinositide dependent protein kinase that phosphorylates and activates protein kinase B?. A recombinant polynucleotide encoding a protein kinase as defined. Uses of the protein kinase and polynucleotide, especially in screening for new drugs.Type: GrantFiled: July 5, 2002Date of Patent: April 17, 2007Assignee: Medical Research CouncilInventor: Dario Renato Alessi
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Patent number: 7172778Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.Type: GrantFiled: December 30, 2003Date of Patent: February 6, 2007Assignee: South Alabama Medical Science FoundationInventors: Steven W. Bailey, June E. Ayling
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Patent number: 7122360Abstract: Substantially pure two kinase domain protein kinases comprising the amino acid sequences provided in the description, variants, fusions, fragments, or derivatives thereof useful in screening assays for drugs. Applications thereof in the modulation of CREB, COX2 and IL2 activities.Type: GrantFiled: June 8, 1999Date of Patent: October 17, 2006Assignee: University of DundeeInventors: Dario Alessi, Marin Deak, Philip Cohen, Matilde Caivano
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Patent number: 7112661Abstract: The present invention is directed to a method of selecting a clone that binds to human platelet glycoprotein Ib alpha using a human variable heavy chain and variable light chain immunoglobulin library. The invention is further directed to isolated nucleic acid molecules encoding a variable heavy chain or variable light chain region of an antibody, wherein the antibody binds to human platelet glycoprotein Ib alpha and inhibits aggregation of platelets. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for producing the variable heavy chain or the variable light chain region. An isolated variable heavy chain or variable light chain region of an antibody, wherein the antibody binds to human platelet glycoprotein Ib alpha and inhibits aggregation of platelets, is also provided. An antibody comprising the variable heavy chain or variable light chain regions is provided, as is a composition comprising the antibody and a carrier.Type: GrantFiled: October 29, 1999Date of Patent: September 26, 2006Assignee: The Research Foundation of State University of New YorkInventor: Jonathan L. Miller
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Patent number: 7109343Abstract: Compounds having the formula: are disclosed. M1 and M2 are the same or different and are transition metal atoms or ions; Z2 and Z3, independently, are the atoms necessary to complete a 3–12 membered heterocyclic ring; Z1 is an alkylene or arylene group; Q1 and Q2 are the same or different and are electron withdrawing groups; L1 and L3, taken together, represent —O—CR13—O—; L2 and L4, taken together, represent —O—CR14—O—; and R13 and R14 are the same or different and are selected from the group consisting of alkyl groups and aryl groups or R13 and R14 represent alkylene or arylene groups that are directly or indirectly bonded to one another. Methods for making such compounds are also disclosed, as are intermediates which can be used in their preparation. Also disclosed are methods for carrying out C—H insertion reactions using bis-transition metal catalysts, such as the above compounds. Procedures for preparing d-threo methylphenidate, tolterodine, CDP-840, nominfensine, and sertraline, are described.Type: GrantFiled: April 5, 2004Date of Patent: September 19, 2006Assignee: The Research Foundation of State University of New YorkInventor: Huw M. L. Davies
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Patent number: 7090841Abstract: The invention provides a method of decreasing human immunodeficiency virus entry into cells, the method comprising decreasing levels of functional CD63 present with the human immunodeficiency virus and the cells. The invention further provides a method of treating or preventing human immunodeficiency virus infection in a subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of functional CD63 in the cells of the subject.Type: GrantFiled: May 1, 2001Date of Patent: August 15, 2006Assignee: The Board of Regents of the University of Texas SystemInventors: William A. O'Brien, Kathie Grovit-Ferbas
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Patent number: 7083511Abstract: A method of activating serum and glucocorticoid-induced protein kinase (SGK) is provided wherein the SGK is phosphorylated. The SGK may be phosphorylated by PDK1 and/or a preparation containing PDK2 activity. A method of identifying a compound that modulates the activity of SGK is provided, wherein the activity of SGK is measured by measuring the phosphorylation by SGK of a polypeptide comprising an amino acid sequence corresponding to the consensus sequence (Arg/Lys; preferably Arg)-X-(X/Arg)-X-X-Ser/Thr)-Z wherein X indicates any amino acid, X/Arg indicates any amino acid, with a preference for arginine, and Z indicates that the amino acid residue is preferably a hydrophobic residue. The SGK may be activated by phosphorylation.Type: GrantFiled: December 14, 1999Date of Patent: August 1, 2006Assignee: The University of DundeeInventors: Philip Cohen, Takayasu Kobayashi, Maria Deak
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Patent number: 7074888Abstract: The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.Type: GrantFiled: March 1, 1999Date of Patent: July 11, 2006Assignee: The Research Foundation of State University of New YorkInventors: Jonathan L. Miller, Vicki A. Lyle
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Patent number: 7074233Abstract: Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue.Type: GrantFiled: June 25, 2004Date of Patent: July 11, 2006Assignees: Board of Regents, The University of Texas System, BioTex, Inc.Inventors: Ashok Gowda, Roger J. McNichols, Massoud Motamedi, Pankaj J. Pasricha
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Patent number: 7030051Abstract: Disclosed is method for increasing the efficiency of a dirhodium catalyst. The method includes providing a dirhodium catalyst, providing an organic ester, and contacting the dirhodium catalyst and the organic ester under conditions effective to increase the efficiency of the dirhodium catalyst. The organic ester is selected such that it is not a substrate for catalysis by the dirhodium catalyst. Dirhodium catalyst compositions which include a dirhodium catalyst and an organic ester are also disclosed. In these compositions, the organic ester is not a substrate for catalysis by the dirhodium catalyst. The method and compositions can be used in a number of reactions, including insertion reactions (e.g., C—H insertions, Si—H insertions, O—H insertions, and N—H insertions) cyclopropanation reactions, annulations (e.g., [3+2] annulations and [3+4] annulations), and ?,?-diarylalkanoate syntheses.Type: GrantFiled: August 27, 2002Date of Patent: April 18, 2006Assignee: The Research Foundation of State University of New YorkInventor: Huw M. L. Davies
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Patent number: 7019399Abstract: The invention relatse to a copper diffusion barrier which includes a diamond-like material includes carbon, hydrogen, silicon, oxygen and a metal and is a copper diffusion barrier. Another aspect of the invention relates to an integrated circuit which includes a copper interconnect, a dielectric material and the copper diffusion barrier.Type: GrantFiled: January 22, 2002Date of Patent: March 28, 2006Assignee: N.V. Bekaert S.A.Inventors: Chandra Venkatraman, Cyndi L Brodbeck, Matthew P. Kirk
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Patent number: 6998636Abstract: The invention relates to a material including carbon, oxygen, silicon and hydrogen and having a dielectric constant of from about 2.1 to about 3.0 where an FTIR scan of the material includes at least two major peaks signifying Si—CH3 bonding. The invention further relates to a material which has a variable dielectric constant through the thickness of the material. Another aspect of the invention is the method of making the material.Type: GrantFiled: March 20, 2001Date of Patent: February 14, 2006Assignee: N.V. Bekaert S.AInventors: Chandra Venkatraman, Cyndi L. Ackerman
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Patent number: 6962891Abstract: Disclosed are dirhodium catalyst compositions. One such dirhodium catalyst composition includes a dirhodium catalyst and a solid support. The dirhodium catalyst includes a Rh—Rh moiety and four bridging ligand moieties. The dirhodium catalyst and the solid support are bound together, but they are not covalently bound together via one or more of the bridging ligand moieties. Another such dirhodium catalyst composition includes a dirhodium tetracarboxylate catalyst and a solid support, and the dirhodium tetracarboxylate catalyst and the solid support are bound together. Yet another such dirhodium catalyst composition includes a dirhodium catalyst and a solid support, where the dirhodium catalyst includes a Rh—Rh moiety and where the dirhodium catalyst and the solid support are bound together via at least one of the rhodiums' axial positions. The compositions can be used in a number of reactions, including insertion reactions (e.g.Type: GrantFiled: August 27, 2002Date of Patent: November 8, 2005Assignee: The Research Foundation of State University of New YorkInventors: Huw M. L. Davies, Tadamichi Nagashima
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Patent number: 6958151Abstract: Disclosed are polypeptides which include an amino acid sequence corresponding to CCXXXCKEGXXC (SEQ ID NO:1). Also disclosed are methods for inhibiting the activity of a flavivirus or other virus by contacting the virus with a miniprotein ligand under conditions effective for the miniprotein ligand to bind to the virus. Methods for detecting a flavivirus or other virus in a sample by contacting the sample with a miniprotein ligand and determining whether the miniprotein ligand is bound to a flavivirus or other virus as also disclosed, as are methods of assessing a compound's usefulness in inhibiting the activity of a flavivirus or other virus.Type: GrantFiled: March 17, 2003Date of Patent: October 25, 2005Assignee: Board of Regents, The University of Texas SystemInventors: Robert O. Fox, Alan D. Barrett, Xiuzhen Fan, Michael R. Holbrook
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Patent number: 6946140Abstract: Methods and compositions for enhancing fibroblast migration at a wound site are disclosed. The method includes contacting the wound site with fibrinogen that is prepared by a process which includes precipitating plasma with glycine. The compositions includes a lipid rich component and fibrinogen.Type: GrantFiled: February 9, 2000Date of Patent: September 20, 2005Assignee: The Research Foundation of State University of New YorkInventors: Richard A. Clark, Dennis K. Galanakis, Azmin Kahn
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Patent number: 6902886Abstract: The invention provides methods of determining the presence of a nuclear localization signal and/or the presence of a nuclear export signal in a protein of interest. The invention further provides chimeric nucleic acids and recombinant host cells for use in such methods. Additionally provided is a nucleic acid molecule encoding a modified LexA protein, wherein the modified LexA protein has no nuclear localization signal, as well as the modified LexA protein itself. In the nuclear import assay, if a protein of interest fused to a mLexA-Gal4AD hybrid contains a functional NLS, the fusion product will enter the yeast cell nucleus and activate the expression of reporter genes. In the nuclear export assay, if a protein of interest fused to a mLexA-SV40 NLS-Gal4AD hybrid contains a functional NES, the fusion product localized to the cell nucleus will exit into the cytoplasm, decreasing the reporter gene expression levels.Type: GrantFiled: November 5, 1999Date of Patent: June 7, 2005Assignee: The Research Foundation of State University of New YorkInventors: Vitaly H. Citovsky, Yoon Rhee
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Patent number: 6884600Abstract: A method of identifying a compound which modulates the interaction between a PP1c and a regulatory subunit thereof, the method comprising determining whether a compound enhances or disrupts the interaction between (a) a PP1c or a fragment, variant, derivative or fusion thereof or a fusion of a fragment, variant or derivative and (b) a regulatory subunit which is able to bind to PP1c or a PP1c-binding fragment, variant, derivative or fusion of the subunit or a fusion of the fragment, variant or derivative. A method of affecting cellular metabolism or function, the method comprising administering to a cell (a) a compound which modulates the interaction between a PP1c and a regulatory subunit thereof or (b) a compound which mimics the effect of a regulatory subunit of PP1c or (c) a peptide capable of binding a PP1c and which affects the ability of PP1c to bind to a particular target and/or affects the regulation of PP1c activity, or a functional equivalent thereof.Type: GrantFiled: April 1, 1997Date of Patent: April 26, 2005Assignee: Medical Research Council LondonInventors: Philip Cohen, Patricia Townsend Wade Cohen, David Barford