Patents Represented by Attorney, Agent or Law Firm Roger N. Coe
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Patent number: 6261522Abstract: An apparatus for automatically detecting the presence of a reagent strip (14) having a body fluid sample disposed thereon and for inspecting the reagent strip (14) after the presence of the reagent strip (14) is detected is provided with a detection system adapted to automatically detect the presence of a reagent strip (14) at a reagent strip receiving area (12), a light source (64 or 68) adapted to illuminate the reagent strip (14) after the presence of the reagent strip (14) at the reagent strip receiving area (12) is detected, and a detector (66 or 70) adapted to receive light from the reagent strip (14) when the reagent strip (14) is being illuminated by the light source.Type: GrantFiled: October 13, 1998Date of Patent: July 17, 2001Assignee: Bayer CorporationInventors: David Hough, Willis E. Howard, III, Richard Hurtle, Gary E. Rehm
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Patent number: 6190918Abstract: The present invention provides a device and a process for detecting an analyte in a biological fluid. The device comprises a separating matrix for separating analyte from the fluid and means for detecting the analyte, where the separating matrix contains HEPES buffer, preferably in an amount between 70 and 150 millimolar. The process comprises applying the sample to the device having a separating matrix and then detecting analyte in the sample using the detection means. The presence of HEPES in the separation layer shortened the detection time.Type: GrantFiled: March 6, 1995Date of Patent: February 20, 2001Assignee: Bayer CorporationInventors: Amy H. Chu, Michael J. Wilcox
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Patent number: 6152942Abstract: A vacuum assisted lancing device (10) for obtaining capillary blood from body sites includes a plunger (12) mounted in a barrel or upper housing (24) that upon being pressed by a user, drives a lancet (18) to puncture skin at a body site. A vacuum member such as a diaphragm (38, 66) or bellows (66) is displaced by the plunger (12) and displaces air in the lancing device (10) to create a vacuum. The vacuum draws skin partially into the lancing device (10) causing blood to form at the puncture. The vacuum is then released and the blood is tested.Type: GrantFiled: June 14, 1999Date of Patent: November 28, 2000Assignee: Bayer CorporationInventors: Allen J. Brenneman, D. Glenn Purcell
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Patent number: 5877863Abstract: A readhead for a photometric diagnostic instrument for illuminating a target area substantially uniformly via only a single light-emitting diode (20) and receiving light from the target area so that reagent tests may be performed is provided with a housing (12, 14, 16) adapted to be incorporated in a photometric diagnostic instrument, first and second light sources (20) mounted in a fixed position relative to the housing (12, 14, 16), a light guide (26) mounted to receive light from each of the light sources (20) which conveys, when only one of the light sources (20) is illuminated, substantially all of the light from the light source (20) to illuminate a target area substantially uniformly, and a light detector (70) coupled to receive light from the target area. Each of the first and second light sources (20) is composed of only a single light-emitting diode (20) for emitting substantially monochromatic light of a different wavelength.Type: GrantFiled: March 20, 1997Date of Patent: March 2, 1999Assignee: Bayer CorporationInventors: Gary D. Ross, Nick T. Stock
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Patent number: 5873887Abstract: An automatic blood sampling device is provided with a housing (12, 14, 18, 20), a reciprocable shaft (50) disposed in the housing (12, 14, 18, 20), and a lancet (40) operatively coupled to the shaft (50). The lancet (40) is movable between a retracted position in which the lancet (40) is disposed within the housing (12, 14, 18, 20) and an extended position in which the lancet (40) extends outside of the housing (12, 14, 18, 20).Type: GrantFiled: October 25, 1996Date of Patent: February 23, 1999Assignee: Bayer CorporationInventors: Toby King, Anne Miller
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Patent number: 5868772Abstract: A blood sampling device is provided with a housing, a lancet assembly, a lancet holder which is movable in a lancing direction between a cocked position and a puncture position, and an actuator mechanism disposed in the housing for causing the lancet holder to move from the cocked position to the puncture position. The lancet assembly has a lancet with a sharp tip, a lancet body having at least two angularly spaced ribs which extend outwardly from a central portion of the lancet body, and a protective cap covering the sharp tip of the lancet, the protective cap being attached to the lancet body so that the protective cap is twistably removable from the lancet body.Type: GrantFiled: July 31, 1997Date of Patent: February 9, 1999Assignee: Bayer CorporationInventors: Richard W. LeVaughn, Joseph E. Ruggiero, William C. Taylor
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Patent number: 5866424Abstract: The present invention addresses the need to ensure that clinical tests for urobilinogen in urine are properly working. The invention specifically provides a novel liquid urobilinogen composition which remains stable in liquid form for eighteen months and a method for making the same.Type: GrantFiled: July 10, 1995Date of Patent: February 2, 1999Assignee: Bayer CorporationInventor: Benjamin Ko
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Patent number: 5846490Abstract: Disclosed is an automated supplying system for supplying liquid samples and test strips to an analyzer having a receiving section which receives test strips dipped in liquid samples one by one, a section at which optical characteristics of test pads provided on the received test strips are measured and a section for calculating analytical results of the respective components based on the respective optical characteristics obtained by the measurement.Type: GrantFiled: July 11, 1996Date of Patent: December 8, 1998Assignee: Bayer CorporationInventors: Hiroshi Yokota, Keiji Takahashi
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Patent number: 5826293Abstract: The present invention is a heated wiper blade comprising an elongated blade and a heating element connected to the electrical system of a vehicle. The heating element utilizes a material with a positive temperature coefficient of resistance placed between a pair of conductive members. The conductive members span the length of the heating element to provide a uniform distribution of heat through the length of the blade. Electrical connections to the heating element are preferably located at one end of the blade. The heating element can be located inside the blade or between a semi-rigid attachment member and an upper surface of the blade.Type: GrantFiled: January 14, 1998Date of Patent: October 27, 1998Inventor: Dewey T. Holland
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Patent number: 5724148Abstract: An apparatus for analyzing a body-fluid sample, such as a urine sample, disposed on a reagent pad is provided with means for illuminating the reagent pad on which the body-fluid sample is disposed, means for detecting light received from the reagent pad and generating a first reflectance signal at a first time and a second reflectance signal at a second time, and means for assigning a color to the body-fluid sample based upon the magnitudes of the first and second reflectance signals. The means for assigning the color to the body-fluid sample may include means for determining a pair of color coefficients each of which has a magnitude based upon the magnitudes of the reflectance signals and means for assigning the color to the body-fluid sample based upon the magnitudes of the color coefficients.Type: GrantFiled: May 9, 1996Date of Patent: March 3, 1998Assignee: Bayer CorporationInventors: Willis Howard, III, Gary E. Rehm
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Patent number: 5712131Abstract: This invention provides an improved process of recovering organic acid from an impure process stream, such as a fermentation broth, by the addition of a strong acid or salt thereof to the impure process stream. The process provides for essentially one step purification without the waste disposal problems or large capital investment required by either the conventional lime/sulfuric or solvent extraction recovery processes. The recovery can be further improved by treating the mother liquor remaining after separation of the citric acid crystals to obtain an additional yield. The preferred strong acid is sulfuric acid and the preferred mother liquor treatment is passage through an ion exclusion resin column.Type: GrantFiled: June 2, 1995Date of Patent: January 27, 1998Assignee: Bayer CorporationInventors: Steven W. Felman, Chetna Patel, Bhalchandra H. Patwardhan, David J. Solow
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Patent number: 5702955Abstract: The present invention is a method for the detection of hydrogen peroxide in biological fluids or an aqueous solution which involves contacting the solution with an oxidation-reduction indicator and a transition metal complex. The transition metal complex is either a creatinine coordinated with iron or a guanidine coordinated with iron.Type: GrantFiled: October 6, 1995Date of Patent: December 30, 1997Assignee: Bayer CorporationInventor: Michael Pugia
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Patent number: 5701181Abstract: A fiber optic diffuse light reflectance sensor is disclosed. The sensor employs illumination optical fibers to carry light emitted from a high-intensity, narrow bandwidth LED to a baffle in a readhead where the optical fibers reflect the light off of a reagent test strip. The illumination optical fibers are randomly oriented to create a more uniform light source. The light is reflected off of a pad on a reagent test strip to detect the presence of non-hemolyzed trace and hemolyzed occult blood. The reflected light must pass through another baffle to a bi-convex lens where it is focused onto a detection bundle of optical fibers. The detection bundle is optically coupled with a CCD, where the optical signal is converted to an electrical one for processing and analysis.Type: GrantFiled: May 12, 1995Date of Patent: December 23, 1997Assignee: Bayer CorporationInventors: Anthony Boiarski, Andrew Dosmann
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Patent number: 5663044Abstract: A composition, method and test device for determining the presence of leukocytes, esterase or protease in a test sample are disclosed. The composition comprises an ester which is hydrolyzed in the presence of leukocyte, esterase, or protease to form a reaction product which couples with a diazonium salt to produce a detectable color change. The composition further comprises the salt of an alkaline earth metal which stabilizes the composition during manufacture and prevents the occurrence of false or background color change due to reactivity of the diazonium salt in the absence of leukocyte, esterase or protease.Type: GrantFiled: February 26, 1996Date of Patent: September 2, 1997Assignee: Bayer CorporationInventors: James Noffsinger, Michael J. Pugia, Melvin D. Smith
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Patent number: 5661563Abstract: A reflectance spectroscope, which is provided with one or more optical paths which prevent substantially all singly reflected light rays from reaching the intended destination(s), is provided with a source of illumination for generating light rays, a support member adapted to support a reagent pad, the support member having a position in which the reagent pad is illuminated by the light rays generated by the illumination source, a reflectance detector positioned to receive light rays from the reagent pad, and means for defining an optical path in which substantially all singly-reflected light rays are prevented from reaching the intended destination. The optical path may be between the illumination source and the reagent pad, or between the reagent pad and the area in which the detector is provided.Type: GrantFiled: May 9, 1996Date of Patent: August 26, 1997Assignee: Bayer CorporationInventors: Willis Howard, Gerald H. Shaffer
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Patent number: 5654803Abstract: An apparatus for analyzing a body-fluid sample disposed on a reagent pad is provided with a light bulb for successively illuminating a plurality of different portions of the reagent pad on which the body-fluid sample is disposed and a detector array for detecting light received from the reagent pad and generating a plurality of reflectance signals in response to light received from a corresponding one of the different portions of the reagent pad. The apparatus is also provided with means for determining whether the magnitude of one of the reflectance signals is substantially different than the magnitude of another of the reflectance signals. Where the body-fluid sample is urine, this capability allows the apparatus to detect the presence of non-hemolyzed in the urine sample. The light bulb may successively illuminate a plurality of overlapping portions of the reagent pad, and may successively illuminate at least three different portions of the reagent pad which are linearly offset from each other.Type: GrantFiled: May 9, 1996Date of Patent: August 5, 1997Assignee: Bayer CorporationInventors: Willis E. Howard, III, Marilyn Radtke, Gary E. Rehm
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Patent number: D379516Type: GrantFiled: March 4, 1996Date of Patent: May 27, 1997Assignee: Bayer CorporationInventor: Bryce Rutter
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Patent number: D393716Type: GrantFiled: March 24, 1997Date of Patent: April 21, 1998Assignee: Bayer CorporationInventors: Allen Brenneman, Gregory Lorch, D. Glenn Purcell
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Patent number: D393717Type: GrantFiled: March 21, 1997Date of Patent: April 21, 1998Assignee: Bayer CorporationInventors: Allen Brenneman, Gregory Lorch, D. Glenn Purcell
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Patent number: D400673Type: GrantFiled: July 14, 1997Date of Patent: November 3, 1998Assignee: Bayer CorporationInventors: Mohammad A. Kheiri, Eric W. Miller, Michael Paloian