Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I:
where:
R1 is a group represented by formula (A), (B) or (C);
and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
Type:
Grant
Filed:
April 29, 2003
Date of Patent:
February 17, 2004
Assignee:
Syntex (U.S.A.) LLC
Inventors:
Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun