Abstract: Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N′-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2).

Abstract: Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N′-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (0F-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2).

Abstract: Dry, directly compressed tablets are provided by a blend of from 60 to 90 weight percent of acetaminophen and from 10 to 40 weight percent of non-ionizable lipid having a melting point of from 55.degree. C. to 80.degree. C. The preferred lipid is hydrogenated cotton seed oil. The tablets are characterized by a hardness of at least 5 kgs. When produced by a conventional tabletting machine using a pressure of 1.5 to 20 tons per square inch.

Abstract: The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tablets or implants of biologically active agents. Preferred for producing dry direct compressed products is the combination of: a hydrophobic cellulose derivative; a wax, and, a fatty acid material and/or a neutral lipid since it provides upon dry direct compression a controlled and continuous release tablet or implant of improved structurally integrity against externally imposed forces.

Abstract: The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tablets or implants of biologically active agents. Preferred for producing dry direct compressed products is the combination of: a hydrophobic cellulose derivative; a wax, and, a fatty acid material and/or a neutral lipid since it provides upon dry direct compression a controlled and continuous release tablet or implant of improved structurally integrity against externally imposed forces.

Abstract: Petroleum resins of lightened color while retaining satisfactory melting point and compatiblity are provided by a process which comprises heat soaking a petroleum cracking or reforming fraction containing cationically polymerizable hydrocarbons and from 2 to more than 0.5 weight percent of cyclodienes until the cyclodiene content is no more than 0.5 weight percent distilling said heat soaked petroleum fraction and polymerizing said distilled petroleum fraction in the presence of a polymerization catalyst.

Abstract: Oil is dehydrated and/or desalted by the influence of a dewatering and desalting formulation which can be characterized as an admixture of (i) a demulsifier preferably an alkylene oxide alkyl phenol-formaldehyde condensate such as a poly ethoxylated nonylphenol-formaldehyde condensate and (ii) a deoiler which is usefully a polyol such as ethylene glycol or poly (ethylene glycol) of Mw ranging from 106 to 44,000 and preferably ethylene glycol.The aqueous formulation may usefully contain a cosolvent such as isopropanol.

Abstract: A room temperature aged epoxy resin grout utilizing a mixture of the diglycidyl ether of bis-phenol A and a siliceous aggregate such as sand is markedly improved in creep deformation performance when a reactive diluent such as the diglycidyl ether of cyclohexane dimethanol and a curing agent such as triethylene tetraamine are admixed with said grout.

Abstract: A process for removing suspended solids particularly difficultly filterable inorganic solids from an oil obtained as a refinery process bottom fraction from both steam and catalytic cracking units (e.g. catalytic cracker bottoms) or from coal conversion processes (e.g. coal tar) by adding to the oil an agglomerating agent comprising an oxyalkylated phenol formaldehyde resin glycol ester whereby said solids are clustered together into readily filterable agglomerates.

Abstract: Corrosion inhibition of metals is obtained treating a system with a corrosion-inhibiting amount, preferably 1 to 10000 ppm, of an optionally-substituted .beta.-pyridyl-ethylamine or a salt thereof, which may be prepared by reacting an amine with a vinylpyridine, preferably in the presence of an acidic catalyst such as acetic acid. The .beta.-pyridyl-ethylamine is a compound of the general formula: ##STR1## wherein R is an alkyl, aryl, aralkyl, alkaryl, halo or amino group of a group --COX where X is hydrogen, alkyl, aryl, hydroxy, alkoxy, aryloxy, amino or halo group, n is zero or an integer from 1 to 4, and R.sup.1 and R.sup.2, which may be the same or different, each represent a hydrogen atom, an optionally substituted hydrocarbyl radical, an alkylamino radical, a heterocyclic radical or a group ##STR2## or R.sup.1 and R.sup.2 with the intervening nitrogen atom together represent a saturated or unsaturated heterocyclic ring optionally containing one or more additional heteroatoms.

Abstract: This invention relates to pressure sensitive adhesive formulations which include a block copolymer of styrene and isoprene such as Kraton.RTM. D and a tackifying resin derived from petroleum feedstock polymerized in the presence of aluminum chloride and having a Mw ranging from 800 to 960, a Mn ranging from 500 to 600 with a Mw/Mn ratio of from 1.3 to 1.9, a softening point of 78.degree. to 81.degree. C. and a glass transition temperature of about 50.degree. C. whereby the adhesive formulations have a rolling ball tack of less than 5 cm., a 180.degree. peel of higher than 3 pounds per inch, a 90.degree. quick stick of higher than 3 pounds per inch and a Polyken tack of higher than 1,000 g/cm.sup.2.

Abstract: A hydrocarbon solvent-based dispersant formulation which combines heavy oil penetrability, activity on oil spills on either fresh or salt water, and the density and viscosity required for controllable aerial spray application is provided by the combination of sorbitan monoesters of C.sub.10 -C.sub.20 aliphatic carboxylic acids and polyoxyalkylene adducts thereof, polyoxyalkylene adducts of sorbitan triesters of C.sub.10 -C.sub.20 aliphatic carboxylic acids, and a water-dispersible salt of a dialkyl sulfosuccinate dissolved in an isoparaffinic hydrocarbon. The addition of a viscosity modifying solvent may be advantageous for adjusting the formulation to needs of specific aerial application procedures.

Abstract: Ethylene-vinyl acetate copolymers having a melt index of 700 to 10000 and containing from 11 to 40% vinyl acetate are useful in hot melt systems and particularly in formulating low viscosity hot melt adhesives, preferably in binary compositions with natural or synthetic resin tackifiers. The adhesives show long open times with short setting times, and excellent adhesive properties.The EVAs are prepared by a high pressure polymerization, preferably by using chain transfer agent such as isobutylene to achieve high melt indices.

Abstract: Hot melt compositions comprising a mixture of an adhesive ethylene-vinyl acetate copolymer having a melt index of 700 to 10000 and containing from 9 to 40% vinyl acetate in combination with an olefin rubber exhibit excellent adhesive properties. The resulting blends have good elevated temperature resistance; outstanding low temperature flexibility, excellent adhesion to a wide variety of surfaces and markedly reduced melt viscosities at the application temperature.

Abstract: A room temperature aged epoxy resin grout utilizing a mixture of the diglycidyl ether of bis-phenol A and a siliceous aggregate such as sand is markedly improved in creep deformation performance when a reactive diluent such as the diglycidyl ether of cyclohexane dimethanol and a curing agent such as triethylene tetraamine are admixed with said grout.

Abstract: Aqueous drilling fluids containing a minor amount of an additive composition featuring oxazolines of C.sub.1 -C.sub.30 alkylthioglycolic acid. Such fluids are especially useful where reduced torque drilling fluids are needed. Another embodiment of this invention relates to a method of drilling utilizing the above-described fluids.

Abstract: An aqueous petroleum resin emulsion is realized by the slow addition of part of the water with vigorous agitation to a resin blended with up to 10 weight percent resinplast and in the presence from 3 to 10 weight percent of an emulsifier until inversion and thereafter adding the balance of the water at low agitation and thereafter cooling said emulsion to a temperature at least 20.degree. C. below the softening point of the mixture of emulsifier, resin and resinplast prior to terminating agitation.

Abstract: An aqueous petroleum resin emulsion is realized by the slow addition of part of the water with vigorous agitation to a resin blended with up to 10 weight percent resinplast and in the presence from 3 to 10 weight percent of an emulsifier until inversion and thereafter adding the balance of the water at low agitation and thereafter cooling said emulsion to a temperature at least about 20.degree. C. below the softening point of the mixture of emulsifier, resin and resinplast prior to terminating agitation.

Abstract: A bis-oxazoline of the formula: ##STR1## wherein R represents an alkyl group of 6 to 50 carbons and X is selected from the group containing of an alkyl or hydroxyalkyl group and at least one of the X substituents being a hydroxy alkyl group of the structure --(CH.sub.2).sub.n OH where n is 1 to 3, which is useful in improving the lubricity of aqueous drilling muds.

Abstract: An oil-in-water emulsion of crude oil, water and hydrophilic surfactant is resolved by first heating said emulsion until it separates into a surfactant laden water layer and an oil-rich emulsion layer, removing the water layer from the oil-rich emulsion layer, treating the emulsion layer by the addition of from 20 to 40 volume percent of water containing a demulsifier and recovering the crude oil which separates from the water upon standing.