Abstract: Monoclonal antibodies reactive with oncogenic and activated ras p21 proteins containing aspartic acid or valine at position 13 and unreactive with normal ras p21 proteins containing glycine at position 13. The antibodies are secreted by hybridomas obtained by immunizing mice with synthetic peptides corresponding in amino acid sequence to positions 5-19 or normal ras p21 proteins, except having aspartic acid or valine in place of glycine at position 13 and except for the addition of cysteine at the amino terminal end of the peptide. The antibodies and immunoreactive fragments are useful in the diagnosis, staging and classification of malignant and premalignant lesions.

Abstract: The invention provides chemically modified proteins having a group of the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, and a method of producing the same. The chemically modified proteins according to the invention can be produced by reacting a protein with an imidoester of the formula: ##STR2## wherein R, n and m are as defined above, R' represents a group constituting an imidoester with an adjacent imidoyl group. The chemically modified proteins according to the invention are useful as drugs, among others.

Abstract: Recombinant fowlpox virus (FPV) capable of expressing immunogenic proteins of fowl pathogens are described. The FPV express DNA of the pathogen under the direction of FPV promoters. The recombinant FPV provide live vaccines for poultry and other animals.

Abstract: Monoclonal antibodies reactive with oncogenic and activated ras p21 proteins containing glutamic acid, arginine or valine at position 12 and unreactive with normal ras p21 proteins containing glycine at position 12. The antibodies are secreted by hybridomas obtained by immunizing mice with synthetic dodecapeptides corresponding in amino acid sequence to positions 5-16 of normal ras p21 proteins, except having glutamic acid, arginine or valine in place of glycine at position 12. The antibodies and Fab fragments thereof are useful for diagnosis, staging and classification of malignant and premalignant lesions.

Abstract: Organosilicon-metal polymers are prepared by mixing an organosilicon polymer containing a multiplicity of Si-H and/or Si-Si functional groups with a sufficient quantity of a metal carbonyl for the metal carbonyl to be incorporated into the organosilicon polymer. These polymers can be used to prepare ceramics.

Abstract: A process for the preparation of crystalline oxytitanium phthalocyanine showing a distinct diffraction in peak at a Bragg angle (2.theta..+-.0.2.degree.) of 27.3.degree. in the X-ray diffraction spectrum, which comprises mechanically pulverizing oxytitanium phthalocyanine, dispersing it in water to form a suspension, adding an organic solvent into the suspension and heating the suspension.

Abstract: A body electrode holder includes a holding member to be disposed on an outer surface of a living body, and a plurality of perforations formed in predetermined positions of the holding member, through which perforations a plurality of body electrodes pass respectively, the holding member being formed of a sheet material. The predetermined positions correspond to portions of the living body in which portions bioelectricity is to be measured. The body electrode holder makes it possible to a plurality of body electrodes at once and easily to predetermined positions without requiring special technic or knowledge regarding positions to attach the body electrodes.

Abstract: A protein having molecular weight of approximately 16 kD which is also cleaved into a protein having a molecular weight of 15 kD is disclosed. This protein is referred to as viral protein U and produced by the vpu gene. It is disclosed that this protein has antigenic determinants and can be used to screen for people having the HIV-1 virus.

Abstract: The invention provides a compound of the formula (I): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --Z wherein R is a glycosyl group, m is an optional positive integer, n is an integer from 1 to 3 and Z is --CHO, --CH.sub.2 OH or --COOH.The compound of the formula (I'): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --CHO wherein R, m and n are as defined above and the formula (I"'): R--OCH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --COOH wherein R, m and n are as defined above is useful as a chemically modifying agent for protein.The compound of the formula (I"): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --CH.sub.2 OH wherein R, m and n are as defined above is useful as a protein fractionating agent.

Abstract: Disclosed herein are an N-vinylformamide copolymer having the structural units represented by the following formulas (I) and (II): ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents an alkyl group of 1 to 4 carbon atoms, in which the molar ratio between the structural units (I) and (II) is from 20:80 to 95:5, and a process for producing the N-vinylformamide copolymer.

Abstract: Assays for an anti-pre-S antibody in a human serum by an enzyme immunoassay in which a biotin-avidin system is used are disclosed. The assays include inhibition method, sandwich method, competitive method and Protein A or anti-human IgG antibody method in a solid phase.The assays can determine the anti-pre-S antibody titer in human sera highly sensitively and simply without use of radioactive materials.

Abstract: Preceramic polymers formed by reacting B.sub.10 H.sub.14-n R.sub.n, (where R is a lower alkyl group having from 1 to about 8 carbon atoms, a substituted or unsubstituted cycloalkyl group having from 3 to about 8 carbon atoms, a substituted or unsubstituted lower alkenyl group having from 2 to about 8 carbon atoms, or a substituted or unsubstituted lower aryl group having from 6 to about 10 carbon atoms, and n is a number from zero to about six) with a diamine of the formulaR.sup.1 R.sup.2 N--(E).sub.q --NR.sup.4 R.sup.5,where R.sup.1, R.sup.2, R.sup.4 and R.sup.

Abstract: This invention describes stable tat.sub.III cell lines. It is disclosed that by transfecting a preselected tat.sub.III cell line with a vector containing a sufficient amount of the HTLV-III LTR responsive to tat.sub.III gene products for trans-activation and an enhancer upstream of the tat.sub.III responsive segment, it is possible to express high levels of the tat.sub.III gene products. By including a preselected heterologous gene on this vector, it is also possible to express high levels of a desired gene product. A substantially pure protein comprising 86 amino acids and having an apparent molecular weight of about 14,000 dalton and exhibiting trans-activating activity is also disclosed. This protein and polypeptides having trans-activating ability, which is also disclosed, can be used to produce high levels of a desired gene product.

Abstract: The present invention provides a novel polypeptide which shows higher IFN-.gamma. activity than intact IFN-.gamma. and a method of producing the same.The polypeptides not only possess a remarkable antiviral activity, antitumor activity, immunopotentiating activity but also is highly stable, therefore, it can be used advantageously as pharmaceuticals.

Abstract: A photosensitive member for electrophotography comprising a photosensitive layer on a conductive substrate, said photosensitive layer containing as a binder resin a modified polycarbonate resin having the repeating structural units represented by the following general formula (1) and (2); ##STR1## wherein R.sup.1 and R.sup.2 are selected from a hydrogen atom, an alkyl group having 1-3 carbon atoms and a halogen atom, at least one of R.sup.1 and R.sup.2 being the alkyl or the halogen atom, and ##STR2## the ratio of the repeating structural unit of the general formula (1) to that of the general formula (2) being at least 20:80. This photosensitive member is highly resistant to mechanical wear and the deterioration of sensitivity and chargeability.

Abstract: Optically active derivatives of glycidol are disclosed. These compounds, (2S) and (2R) glycidyl tosylate and (2S) and (2R) glycidyl 4-chloro-3-nitrobenzenesulfonate can be readily crystallized to high enantiomeric purity. Their use in other synthesis reactions is also described.

Abstract: A DNA sequence wherein a DNA segment coding for a signal peptide of the formula:M-R-S-F-L-L-L-A-L-C-F-L-P-L-A-A-L-Gis bound to the 5' end of a DNA segment coding for human lysozyme, a cell transformed with the above DNA sequence and a process for producing human lysozyme, which comprises cultivating the above cell accumulating human lysozyme in the culture and recovering the same are disclosed.The above techniques make the mass production of human lysozyme useful as pharmaceuticals possible. The present signal peptide is superior to that of hen egg white lysozyme for secretive production of human lysozyme.

Abstract: A gene and gene product that regulates the expression of the capsidal envelope genes of HTLV-III/LAV and that can be used to regulate the expression of heterologous (non-viral) genes as well is disclosed. This art gene consists of two exons and can be used in creating nucleotide segments, vectors and cell lines. A new method for screening for compounds that inhibit the replication of HTLV-III is also described and comprises:(1) transfecting a T-cell line with the HTLV-III art and env genes;(2) thereafter, adding a preselected compound to the transformed cell line in increasing concentrations; and(3) determining whether the compound effects the art function without being toxic to the cell.An additional parameter to use in diagnosis of AIDS disease is also described. The use of the art gene and gene product in AIDS therapy is also disclosed.

Abstract: An animal cell line transformed with an expression vector for an animal cell, the expression vector which contains a DNA segment comprising:(a) a DNA sequence coding for a signal peptide of an animal cell-derived protein,(b) a second DNA sequence coding for a different protein from the signal protein joined downstream of said signal peptide encoding DNA sequence without causing any reading frame shift, and(c) a promoter DNA sequence capable of functioning in an animal cell, wherein the promoter sequence is positioned upstream of the signal peptide encoding DNA sequence, can produce glycosylated proteins advantageously as secretable proteins.

Abstract: Disclosed herein is a photoreceptor for electrophotography comprising a conductive substrate and a photosensitive layer thereon containing an azo compound represented by the formula (I):A-N=N-D-N=N-B (I)wherein A represents a coupling component derived from the following formula (II): ##STR1## wherein Q represents a divalent group derived from an aromatic hydrocarbon which may have one or more substituents or a divalent group derived from a heterocyclic compound which may have one or more substituents, B represents a different coupling component having a phenolic hydroxyl group from said A, and D represents a divalent group in which the carbon atoms bonded to the azo groups are SP.sup.2 carbon atoms forming double bonds.