Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.

Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.

Abstract: Disclosed is a process for preparing N-substituted heterocyclic derivatives and its salts using phase transfer catalysis.

Abstract: A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.

Abstract: Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.

Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R.sup.1, R.sup.2 and R.sup.3 are each independently(a) hydrogen, except that R.sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.6 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ;(i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ;(j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or(k) --Z.sup.4 --N(R.sup.11)--Z.sup.5 --NR.sup.9 R.sup.10 ;and the remaining symbols are as defined in the specification.

Abstract: Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: ##STR2## R.sup.2 and R.sup.3 are each independently (a) hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z.sup.1, Z.sup.2 and Z.sup.3 ;(c) halo;(d) hydroxyl;(e) cyano;(f) nitro;(g) --C(O)H or --C(O)R.sup.6 ;(h) --CO.sub.2 H or --CO.sub.2 R.sup.6 ;(i) --SH, --S(O).sub.n R.sup.6, --S(O).sub.m --OH, --S(O).sub.m --OR.sup.6, --O--S(O).sub.m --R.sup.6, --O--S(O).sub.m OH or --O--S(O).sub.m --OR.sup.6 ;(j) --Z.sup.4 --NR.sup.7 R.sup.8 ; or(k) --Z.sup.4 --N(R.sup.11)--Z.sup.5 --NR.sup.9 R.sup.10 ;and the remaining symbols are as defined in the specification.

Abstract: A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.

Abstract: A method is provided for inhibiting onset of or treating phytosterolemia by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug, such as pravastatin.

Abstract: The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-bi phenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methy l]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.

Abstract: Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.

Abstract: Compounds of the formula ##STR1## inhibit endothelin, wherein: R is phenyl, naphthyl or biphenyl, each of which may be substituted.

Abstract: Recycleable bulk bag containers having an exterior fabric layer and an interior fabric layer or interior film liner. Such bulk bag containers are used in the storage and transport of materials in powder, granular and other particulate forms. Such containers carry loads of up to one ton or more.

Abstract: The present invention provides aqueous low (70 weight percent or less) VOC hair styling compositions. More particuarly, the present invention provides a low VOC hair styling composition containing at least one acrylic hair fixative resin and one or more plasticizing compounds selected from polycarboxylic acid esters and dimehiconecoporyols. The present invention also provides a low beading, low VOC hair styling composition comprising at least one surface tension reducing compound, at least one acrylic hair fixative resin, and at least one simeticone. The present invention also provides an aqueous hair resin composition which inhibits microbial growth. The aqueous hair resin composition contains at least one acrylic hair fixative resin and iodopropynylbutylcarbamate.

Abstract: Polymers having amine-thiol terminal moieties are provided. The amine-thiol terminal moieties are imparted by using amine-thiols as chain transfer agents in aqueous addition polymerizations.The polymers are useful as mineral dispersants, as water-treatment additives for boiler waters, cooling towers, reverse osmosis applications, sugar refining, paper production, geothermal processes and oil wells, and as detergent additives acting as builders, anti-filminig agents, dispersants, sequestering agents and encrustation inhibitors.

Abstract: A stabilized aqueous slurry of magnesium hydroxide and a method for preparing the same are provided. The method involves an aqueous magnesium hydroxide slurry prepared with a combination of (a) one or more polymeric dispersants and (b) one or more water-soluble alkali metal salts. Slurries prepared according to the invention are less susceptible to increases in viscosity upon standing and remain flowable after several days.

Abstract: Polycarboxylate additives suitable for use in automatic dishwasher detergent compositions are prepared by polymerizing three or more monomers including monoethylenically unsaturated C.sub.3 to C.sub.6 monocarboxylic acids such as acrylic acid, monoethylenically unsaturated C.sub.4 to C.sub.6 dicarboxylic acids such as maleic acid, and monoethylenically unsaturated esters of acrylic or methacrylic acid. Automatic dishwasher detergents prepared from these additives produce low filming and spotting on washed glassware.

Abstract: An improved toughened blend of an aromatic polyester with from 5 to 20 phr of an impact modifier, which impact modifier is a blend of (a) 80 to 85 weight percent of a core/shell impact modifier having a polybutadiene core and at least one shell formed from methyl methacrylate and styrene; and (b) 15 to 20 weight percent of a linear copolymer which contains from 50 to 85 parts of units derived from ethylene, from 5 to 40 parts of units derived from (meth)acrylic esters, and from 2 to 10 parts of a copolymerizable monomer containing an epoxy group. The toughened blend exhibits higher impact strength than would be calculated for the blend using a linear relationship based on values of notched Izod for two blends, each containing only one of the impact modifiers at an equal use level.

Abstract: The present invention provides a composition useful in a washing process containing at least one vinyl amide polymer. The vinyl amide polymer contains from 5 to 100 weight percent of at least one vinyl amide monomer, and from 0 to 95 weight percent of one or more vinyl ester monomers. The present invention also provides a method of cleaning an article and a method of providing soil resistance to an article using the vinyl amide polymer.

Abstract: The present invention is concerned with improved chelating resins. More particularly, the present invention is concerned with macroporous, aminoalkylphosphonic or iminodiacetic acid chelating resins having improved stability and capacity in the removal of cations (e.g. calcium, magnesium, barium and strontium) from brines and in the removal of metals (e.g. nickel, copper and zinc) from waste streams.