Patents Represented by Law Firm Rosenbaum & Associates
  • Patent number: 7522283
    Abstract: The present invention is directed generally to an apparatus and methods that combine a novel four-port dual-source interferometer with double modulation FT-VCD or FT-VLD measurements to obtain a spectrometer with enhanced signal quality (S/N), and lower susceptibility to detector saturation. In the novel apparatus of the present invention, a linear polarizer or tandem array of identically-oriented polarizers is placed in front of each of the two sources in a four-port dual-source interferometer, with the polarization state of one of the linear polarizers (or tandem array of polarizers) vertical and the polarization state of the other linear polarizer (or tandem array of polarizers) horizontal, i.e., with the polarization axes of the polarizers orthogonal to one another. Methods for measuring these spectra using the various aspects of the apparatus of the present invention are also provided.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: April 21, 2009
    Assignee: Biotools, Inc.
    Inventors: Laurence A. Nafie, Henry Buijs
  • Patent number: 7491226
    Abstract: An implantable endoluminal device that is fabricated from materials that present a blood or body fluid and tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of an monolithic material deposited into a monolayer and etched into regions of structural members and web regions subtending interstitial regions between the structural members. An endoluminal graft is also provided which is made of a biocompatible metal or metal-like material. The endoluminal stent-graft is characterized by having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 17, 2009
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventors: Julio C. Palmaz, Christopher T. Boyle, Christopher E. Banas, Roger W. Wiseman, Denes Marton
  • Patent number: 7465484
    Abstract: A lightweight multilayer heat reflective concrete cure blanket having a moisture-impervious top outer layer, a moisture-impervious bottom outer layer, and the top and bottom layers sealingly connected to each other at the boundaries of the layers to form a moisture-impervious chamber between the first and second layers. The chamber includes at least one bubble type insulative layer therein, and the bottom surface of the blanket comprises a heat reflective material to reflect heat emanating from the concrete when the blanket is placed over the concrete. In a further embodiment, heat reflective material is applied to at least one inner bubble type layer to reflect additional heat which radiates from the concrete through the insulative layer and back towards the concrete.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: December 16, 2008
    Assignee: Midwest Canvas Corporation
    Inventor: Gary Handwerker
  • Patent number: 7354729
    Abstract: The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the growth of hematopoietic stem and progenitor cells and for identifying subpopulations thereof that are suitable for transplantation. The assay of the present invention is particularly useful for quality control and monitoring of the growth potential in the stem cell transplant setting and would provide improved control over the reconstitution phase of transplanted cells.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: April 8, 2008
    Assignee: HemoGenix, Inc.
    Inventor: Ivan N. Rich
  • Patent number: 7354730
    Abstract: The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular ATP content of incubated target cells, and correlate the luminescence with the proliferative status of the cells. The present invention further relates to kits that provide reagent mixes and instructions for high-throughput assays methods for screening compounds that may modulate the proliferative status of a target cell population. The kits of the present invention and methods therein described may be used for determining the proliferative status of any isolated cell line or type. The kits and methods of the present invention address the need for rapid assays that determine the proliferative status of isolated hematopoietic stem and progenitor cells and of subpopulations of differentiated cells thereof.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: April 8, 2008
    Assignee: HemoGenix, Inc.
    Inventor: Ivan N. Rich
  • Patent number: 7338520
    Abstract: This invention relates to prosthetic cardiac and venous valves and a single catheter device and minimally invasive techniques for percutaneous and transluminal valvuloplasty and prosthetic valve implantation.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: March 4, 2008
    Assignee: ABPS Venture One, Ltd.
    Inventors: Steven R. Bailey, Christopher T. Boyle
  • Patent number: 7335426
    Abstract: A vacuum deposition method for fabricating high-strength nitinol films by sputter depositing nickel and titanium from a heated sputtering target, and controlling the sputter deposition process parameters in order to create high-strength nitinol films that exhibit shape memory and/or superelastic properties without the need for precipitation annealing to attenuate the transition conditions of the deposited material. A vacuum deposited nitinol film having high-strength properties equal to or better than wrought nitinol films and which are characterized by having non-columnar crystal grain structures.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: February 26, 2008
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventors: Denes Marton, Christopher T. Boyle, Roger W. Wiseman, Christopher E. Banas
  • Patent number: 7320857
    Abstract: Severe Acute Respiratory Syndrome (“SARS”) is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant evidence suggesting that the coronavirus responsible for the disease (“SARS-CoV”) evolves during an outbreak, there is currently little data on the earliest strains of this coronavirus. The present invention is directed to the characterization of the genomic RNA sequences of these earliest SARS coronaviruses, to the identification of nucleotide positions within the SARS-CoV genomic RNA that are characteristic of the different evolutionary stages of the coronavirus, to kits based on these positions for use in diagnosis of the disease in patients, and for the development of vaccines to the disease based on the lowered virulence and contagiousness of these earliest strains of SARS-CoV.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: January 22, 2008
    Assignee: Chinese National Human Genome Center at Shanghai
    Inventors: Guoping Zhao, Rui Heng Xu, Xinwei Wu, Changchun Tu, Huai-Dong Song, Yixue Li, Jinlin Hou, Jun Xu, Jun Min
  • Patent number: 7301632
    Abstract: The invention describes a method to eliminate instrumental offset in measurement of optically active scattering and circular dichroism. The method uses the time-average measurement of the light that is systematically transformed by a series of optical devices. The optical devises perform the function of rotating linearly polarized light, interconverting left and right circular polarized light, converting circular polarized light to rotating linear polarized light and converting linear polarized light to alternating left and right circular polarized light.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: November 27, 2007
    Assignee: BioTools, Inc.
    Inventor: Werner Hug
  • Patent number: 7300457
    Abstract: Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: November 27, 2007
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventor: Julio C. Palmaz
  • Patent number: 7258856
    Abstract: Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the recombinant forms of the protease, including fragments and mutants with substantial homology are provided. Also provided are pharmaceutical compositions useful for treating wounds that include the disclosed proteases with mitogenic activity. A method of treating wounds is provided using the disclosed proteases.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: August 21, 2007
    Inventors: Carlos E. Salas, Miriam T. P. Lopes, Abraham V. Schnidermann
  • Patent number: 7235098
    Abstract: Implantable medical devices, including stents, grafts, covered stents, catheters, patches or the like having regions of the device which are functionalized employing microelectromechanical systems that are capable of acting as electromechanical sensors or biosensors in response to either an endogenous event, such as tissue growth, biochemical binding events, pressure changes, or respond to an externally applied stimulus, such as RF energy, to cause a change in the state of the device, such as to induce an oscillation signal which may be interrogated and interpreted external the body or may generate an induced electrical or electromagnetic potential in the device to activate micromotors to effect a geometric change in the device.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: June 26, 2007
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventor: Julio C. Palmaz
  • Patent number: 7235092
    Abstract: Guidewires and thin-film catheter-sheaths, fabricated using vacuum deposition techniques, which are monolayer or plural-layer members having ultra-thin wall thicknesses to provide very-low profile delivery assemblies for introduction and delivery of endoluminal devices.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: June 26, 2007
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventors: Christopher E. Banas, Steven R. Bailey, Christopher T. Boyle
  • Patent number: 7195641
    Abstract: This invention relates to improvements in prosthetic cardiac and venous valves and implantable medical devices having moveable septa. The inventive prosthetic cardiac and venous valves have metallic or pseudometallic valves coupled to metallic or pseudometallic stents that permit percutaneous delivery of the devices.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: March 27, 2007
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventors: Julio C. Palmaz, Eugene A. Sprague, Cristina Fuss, Denes Marton, Roger W. Wiseman, Christopher E. Banas, Christopher T. Boyle, Steven R. Bailey
  • Patent number: 7144978
    Abstract: Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunological competence.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: December 5, 2006
    Assignee: Pan Asia Bio Co., Ltd.
    Inventors: Junlian Huang, Michael Min Xu, Xiaojian Hu, Yuhong Xu
  • Patent number: 7138146
    Abstract: The subject of the present invention is acrochordon removal and prevention utilizing safe dependable effective biocompatable treatments with no scarring, bleeding, twisting, yanking, choking, burning, freezing, shocking, screaming and hypo pigmentation or hyper pigmentation. In one aspect of the invention, methods are provided for acrochordon removal comprising application of high concentrations of hydrogen peroxide.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 21, 2006
    Inventors: Mickey Miller, Margaret Ancira
  • Patent number: 7122049
    Abstract: An endoluminal stent composed of a plurality of circumferential expansion elements arrayed to form the circumference of the stent and extending along the longitudinal axis of the stent, and a plurality of interconnecting members that interconnect adjacent pairs of circumferential expansion elements, the interconnecting members joining struts of adjacent pairs of interconnecting members at approximate mid-points of the struts.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: October 17, 2006
    Assignee: Advanced Bio Prosthetic Surfaces, Ltd.
    Inventors: Christopher E. Banas, David G. Rosenbaum
  • Patent number: 7118688
    Abstract: An antioxidant composition having enhanced oxidative stability, emulsion stability, and health benefits. The composition may include individual ingredients or a synergistic blend of non-reducing sugars, sugar polyols, medium-chain triglycerides, polysaccharides, polyphenols, phospholipids, chitosan, and alpha-casein, beta-casein, kappa-casein or protein fragments, glycopeptides, phosphopeptides. The composition may optionally be further utilized for the prevention of hypercholesterolemia or bone mineral loss.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: October 10, 2006
    Assignee: The Texas A&M University System
    Inventors: Adela Mora-Gutierrez, Michael H. Gurin
  • Patent number: 7018408
    Abstract: This invention relates to prosthetic cardiac and venous valves and a single catheter device and minimally invasive techniques for percutaneous and transluminal valvuloplasty and prosthetic valve implantation.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: March 28, 2006
    Assignee: ABPS Venture One, Ltd.
    Inventors: Steven R. Bailey, Christopher T. Boyle
  • Patent number: D519794
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: May 2, 2006
    Assignee: Chefs Planet, LLC
    Inventor: D. David Roberts