Abstract: A clamping assembly for connecting and disconnecting aligned hubs of a first and a second pressure vessel is provided. The clamping assembly includes a pair of clamp segments and at least one cam in operable engagement with the clamp segments. The clamp segments are movable between a closed position to engage the hubs and an open position to disengage from the hubs. The movement of the clamp segments from the closed position to the open position operates the cam to separate the hubs.