Abstract: An inbred corn line, designated LH261, is disclosed. The invention relates to the seeds of inbred corn line LH261, to the plants of inbred corn line LH261 and to methods for producing a corn plant produced by crossing the inbred line LH261 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH261 with another corn line.

Abstract: The present invention is directed to conotoxin peptides having 25-35 amino acids, six cysteines which form three disulfide bonds between the first and fourth, second and fifth, and third and sixth cysteines, respectively. The invention is directed to .delta.-conotoxin GmVIA having the formula Val-Lys-Pro-Cys-Arg-Lys-Glu-Gly-Gln-Leu-Cys-Asp-Pro-Ile-Phe-Gln-Asn-Cys-Cy s-Arg-Gly-Trp-Asn-Cys-Val-Leu-Phe-Cys-Val (SEQ ID NO:1). This peptide activates sodium channels. The invention is further directed to .mu.O-conotoxin peptides of the generic formula Ala-Cys-Xaa.sub.1 -Lys-Lys-Trp-Glu-Tyr-Cys-Ile-Val-Pro-Ile-Xaa.sub.2 -Gly-Phe-Xaa.sub.3 -Tyr-Cys-Cys-Pro-Gly-Leu-Ile-Cys-Gly-Pro-Phe-Val-Cys-Val, wherein Xaa.sub.1 is Arg or Ser, Xaa.sub.2 is Ile or Leu and Xaa.sub.3 is Ile or Val (SEQ ID NO:2). These peptides block sodium channels. Examples of .mu.

Abstract: The effects of suppressing c-fos oncogene expression on drug or radiation resistant mammalian cells are described. A2780S human ovarian carcinoma cells with resistance to actinomycin D were isolated and the resultant A2780AD cells exhibited the MDR phenotype. A hammerhead ribozyme designed to cleave fos RNA cloned into the pMAMneo plasmid was transfected into A2780AD cells. Induction of the ribozyme resulted in decreased expression of c-fos, followed by that of mdr-1, c-jun, and p53. Reversal of the MDR phenotype by the anti-mdr ribozyme occurred one-fourth as rapidly as that induced by the anti-fos ribozyme. These studies demonstrate the primacy of the c-fos oncogene in maintaining the resistant phenotype in human cancer cells. Thus, down regulation of fos/jun will make resistant cancer cells more sensitive to conventional treatment, i.e., cancer chemotherapeutic agents and/or radiation.

Abstract: In a double-chuck mechanical pencil provided with an eraser, the torsional breakage of a lead gripped by a front lead chuck and a back lead chuck due to the turning of a lead tank caused when an eraser is used is prevented, and inconvenience to a lead supplying operation caused by the abrasion of the eraser is eliminated.

Abstract: A process for hollowing out a cavity, by dissolution, in a ground formation comprising at least one layer containing predominantly salt, the process including the steps of drilling at least one hole having a substantially horizontal section arranged at least in part in the salt layer, providing in the drilled hole(s) an injection pipe, an extraction pipe and a preliminary communication space connecting the injection pipe and the extraction pipe, injecting a solvent of the salt, into the communication space, through one end of the injection pipe forming an injection point, extracting, through the extraction pipe, the brine formed by the dissolution of the salt, in contact with the solvent, producing a plurality of preliminary sub-cavities in the salt layer, and producing a succession of channels, isolated from the layer, the succession of channels connecting the plurality of preliminary sub-cavities in a fluid manner two at a time in order to form an open circuit for circulation of the solvent, expending betwe

Abstract: The invention relates to a gas mixing burner (80) equipped with a flame retention device (1). This device incorporates in its construction a compressed gauze of interwoven flexible metal wire or wires for said gases to flow through it, and takes the form of a ring (2), characterised in that it is constituted by a substantially coaxial stack of at least two of said rings (2). Such a device may in particular be mounted on cylindrical domestic burners.

Abstract: The present invention relates to mutations in the MKK4 gene in human cancers and their use in the diagnosis and prognosis of human cancer. Specific mutations in the MKK4 gene which are associated with breast, pancreatic, colorectal and testicular cancers have been identified. The invention also relates to the therapy of human cancers which have a mutation in the MKK4 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Abstract: The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Abstract: A novel soybean cultivar, designated 922286942427, is disclosed. The invention relates to the seeds of soybean cultivar 922286942427, to the plants of soybean 922286942427 and to methods for producing a soybean plant produced by crossing the cultivar 922286942427 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 922286942427 with another soybean cultivar.

Abstract: The present invention relates to methods for inhibiting the complement pathway in a mammal comprising administering an effective dose of a composition comprising an active ingredient selected from the group consisting of isolated sea cucumber (Phylum Echinodermata, Class Holothuroidea) body wall, isolated sea cucumber epithelial layer, isolated sea cucumber flower, sea cucumber fucosylated chondroitin sulfate, combinations thereof, active derivatives thereof or combinations of active derivatives thereof.

Abstract: An inbred corn line, designated LH229, is disclosed. The invention relates to the seeds of inbred corn line LH229, to the plants of inbred corn line LH229 and to methods for producing a corn plant produced by crossing the inbred line LH229 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH229 with another corn line.

Abstract: A system and method for controlling and monitoring remote distributed processing systems from one or more control processing systems by downloading agent-application programs from the control processing systems to remote control middleware modules on the distributed processing systems, where the control processing systems have a library of available agent-application(s). The agent-application(s) are compiled by or at the direction of the remote control middleware and executed within operational parameters determined by the control processing systems.

Abstract: A novel soybean cultivar, designated 95-04386, is disclosed. The invention relates to the seeds of soybean cultivar 95-04386, to the plants of soybean 95-04386 and to methods for producing a soybean plant produced by crossing the cultivar 95-04386 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 95-04386 with another soybean cultivar.

Abstract: The catheter is a catheter for controlling the circulation of fluid through it, from or to a vessel in which the catheter is inserted. The catheter comprises a long tubular body that is open especially at its distal end (5), over which there is arranged a cap (5) having an essentially flat distal wall (7) in which there is formed at least one slit forming a valve (7).The slit in the cap has a length that is greater than or equal to the inside diameter of the body of the catheter. The said slit preferably extends also into the side of the cap, and a tube is inserted into the distal portion of the catheter in order to support the sleeve during aspiration.

Abstract: A novel soybean cultivar, designated 947262953, is disclosed. The invention relates to the seeds of soybean cultivar 947262953, to the plants of soybean 947262953 and to methods for producing a soybean plant produced by crossing the cultivar 947262953 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 947262953 with another soybean cultivar.

Abstract: A method for C-Terminal degradation of peptides and proteins involves forming a thiohydantoin derivative of the C-Terminal amino acid and then cleaving the derivatized amino acid by reaction with methoxide or methiolate ions.

Abstract: A novel soybean cultivar, designated 931581550742, is disclosed. The invention relates to the seeds of soybean cultivar 931581550742, to the plants of soybean 931581550742 and to methods for producing a soybean plant produced by crossing the cultivar 931581550742 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 931581550742 with another soybean cultivar.

Abstract: The present invention provides inhibition of angiogenesis in a warm-blooded animal by the administration of preparations isolated from the echinoderm sea cucumber (Class Holothuroidea). This preparation is useful as a therapeutic agent against malignant tumors and as a preventive or therapeutic drug against various diseases, such as rheumatoid arthritis, caused by vascular hyperplasia.

Abstract: A telephone capable of facilitating identification of a party by intuition and improving operability by providing a portrait representative of an image of the party. The telephone includes a portrait montage portion for combining portrait elements into a composite portrait associated with a called party; a recording portion for recording in a memory table the composite portrait in conjunction with its name and telephone number; a selectively read portion for selectively reading from the memory table the composite portrait, name and telephone number; a display unit for displaying, when forming the composite portrait by the portrait image montage portion, the portrait elements and a composite portrait generated by combining them, and for displaying the composite portrait, its name and telephone number, which are read by the selectively read portion; and an automatic dialing portion for dialing the telephone number which is read by the selectively read portion and displayed on the display unit.

Abstract: This invention relates to a new and distinct Canna generalis cultivar which is outstanding because of its compact dwarf growth habit, its pastel yellow color with lime-green hue, its long-term bloom display, its apple green foliage edged with white margins, its large, healthy rhizomes, and its ultra dwarf early bloom display.