Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
Type:
Grant
Filed:
October 9, 1998
Date of Patent:
May 7, 2002
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
Abstract: This invention relates to a series of substituted piperazines of Formula II, as well as enantiomers thereof
These compounds are useful in the manufacture of pharmaceutical compositions.
Type:
Grant
Filed:
January 21, 2000
Date of Patent:
March 26, 2002
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
Gee-Hong Kuo, William V. Murray, Catherine P. Prouty
Abstract: The present invention relates to a clear colorless soap bar with superior mildness, lathering and discoloration resistance. The clear colorless soap consists of a blend of C12-C18 fatty acids neutralized with sodium hydroxide (NaOH) and triethanolamine (TEA). Excess TEA acts as a co-solvent and is responsible for clarity of the soap bar. The bar also contains a branched chain acid such as isostearic acid to break up crystallinity and add to product clarity. Low color and color stability are obtained by removing unsaturated fatty acids, and by the use of antioxidants (BHT and Vitamin E). Low levels of C6 to C10 fatty acids provide exceptional mildness.
Type:
Grant
Filed:
October 22, 1997
Date of Patent:
October 5, 1999
Assignee:
Johnson & Johnson Consumer Products, Inc.