Patents Represented by Attorney Ruth H. Newtson

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  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 4999373
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA: cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: March 12, 1991
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Aminoalkyl-substituted azetidine platinum(II) complexes
    Patent number: 4970324
    Abstract: Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity against transplanted L1210 and P388 murine leukemia cell lines.
    Type: Grant
    Filed: January 8, 1988
    Date of Patent: November 13, 1990
    Inventors: James D. Hoeschele, David A. Berry, Luigi G. Marzilli
  • Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
    Patent number: 4957940
    Abstract: Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: September 18, 1990
    Assignee: Warner-Lambert Company
    Inventor: Bruce D. Roth
  • Didemnins and nordidemnins
    Patent number: 4950649
    Abstract: Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting acute myelocytic leukemia and acute lymphocytic leukemia.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: August 21, 1990
    Assignee: University of Illinois
    Inventor: Kenneth L. Rinehart
  • Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis
    Patent number: 4950675
    Abstract: Certain trans-6,6'-[[(substituted)pyridin-3,5-diyl]-dialkane- and dialkene-diyl]bis [tetrahydro-4-hydroxypyran]-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: August 21, 1990
    Assignee: Warner-Lambert Company
    Inventor: Alexander Chucholowski
  • 11a-hydroxy steroid diester
    Patent number: 4948533
    Abstract: The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17.alpha.-hydroxy-11.alpha.-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: August 14, 1990
    Assignee: The Upjohn Company
    Inventors: John M. Braughler, Edward D. Hall, Wendell Wierenga, John M. McCall
  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 4948806
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: August 14, 1990
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Tetrahydropyridine oxime compounds
    Patent number: 4929734
    Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: May 29, 1990
    Assignee: Warner-Lambert Company
    Inventors: Linda L. Coughenour, Robert E. Davis, David A. Downs, Thomas G. Heffner, Leonard T. Meltzer, Walter H. Moos, David W. Moreland, Haile Tecle
  • 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis
    Patent number: 4929620
    Abstract: Certain trans-6-[[(substituted)pyrimidin-5-yl]-ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: May 29, 1990
    Assignee: Warner-Lambert Company
    Inventors: Alexander W. Chucholowski, Bruce D. Roth, Drago R. Sliskovic
  • Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
    Patent number: 4906657
    Abstract: Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: March 6, 1990
    Assignee: Warner-Lambert Company
    Inventor: Bruce D. Roth