Patents Represented by Attorney S. B. Abrams - Justia Patents Search

Patents Represented by Attorney S. B. Abrams

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Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin

Patent number: 4755508

Abstract: Benzodiazepines of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).

Type: Grant

Filed: February 27, 1987

Date of Patent: July 5, 1988

Assignee: Merck & Co., Inc.

Inventors: Mark G. Bock, Ben E. Evans, Roger M. Freidinger
Amides and esters of 2-(N-(hydroxypiperidinoalkyl) and (hydroxypyrrolidinoalkyl)-aminosulfonyl)-6-nitrobenzoic acids useful as adjuncts to radiation therapy

Patent number: 4731369

Abstract: Amides and esters of 2-[N-(hydroxypiperidinoalkyl) and (hydroxypyrrolidinoalkyl) aminosulfonyl]-6-nitrobenzoic acids are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds, pharmaceutical compositions including such compounds and methods of treating patients in need of therapeutic radiation with effective amounts of such compounds.

Type: Grant

Filed: June 26, 1987

Date of Patent: March 15, 1988

Assignee: Merck & Co. Inc.

Inventors: Edward L. Engelhardt, Walfred S. Saari