Patents Represented by Attorney, Agent or Law Firm S. Christopher Bauer
  • Fused G-CSF and IL-3 proteins and uses thereof
    Patent number: 6730303
    Abstract: Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: May 4, 2004
    Assignee: Pharmacia Corporation
    Inventors: Yiqing Feng, Nicholas R. Staten, Charles M. Baum, Neena L. Summers, Maire Helena Caparon, S. Christopher Bauer, Linda L. Zurfluh, John P. McKearn, Barbara K. Klein, Stephen C. Lee, Charles A. McWherter, Judith G. Giri
  • Circular permuteins of flt3 ligand
    Patent number: 6660257
    Abstract: Disclosed are novel flt-3 receptor agonist proteins, DNAs which encode the flt-3 receptor agonist proteins, methods of making the flt-3 receptor agonist proteins and methods of using the flt-3 receptor agonist proteins.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: December 9, 2003
    Assignee: Pharmacia Corporation
    Inventors: Charles A. McWherter, Yiqing Feng, John P. Mc Kearn, Nicholas R. Staten, Philip R. Streeter, Susan L. Woulfe, Nancy I. Minster, John C. Minnerly
  • Peptide linkers for covalent linking polypeptide cell modulators
    Patent number: 6545124
    Abstract: Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities. Also described is a peptide linker segment comprising a mouse IgG gamma 2b “hinge” in which the four cysteines of the “hinge” have been converted to serines.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: April 8, 2003
    Assignee: Pharmacia Corporation
    Inventors: Leslie David Bell, Keith Graham McCullagh, Alan George Porter
  • Methods of using interleukin-3 (IL-3) mutant polypeptides for ex-vivo expansion of hematopoietic stem cells
    Patent number: 6479261
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (a.a.119 to 133) have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: November 12, 2002
    Assignee: Pharmacia Corporation
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John Patrick McKearn, Peter Olins, Kumnan Paik, Joseph Polazzi, John Warren Thomas
  • Interleukin-3 (IL-3) multiple mutation polypeptides
    Patent number: 6458931
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (a.a.119 to 133) have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 1, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Bradford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John Patrick McKearn, Peter Olins, Kumnan Paik, John Warren Thomas
  • Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides
    Patent number: 6440407
    Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: August 27, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John W. Thomas
  • Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
    Patent number: 6436387
    Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: August 20, 2002
    Assignee: G.D. Searle & Co.
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John W. Thomas
  • Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
    Patent number: 6413509
    Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3), which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted, and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: July 2, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John Thomas
  • Compositions for increasing hematopoiesis with interleukin-3 mutants
    Patent number: 6403076
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 11, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Marie Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John Patrick McKearn, Peter Q Olins, Kumnan Paik, John Warren Thomas
  • Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
    Patent number: 6379662
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 30, 2002
    Inventors: John P. McKearn, Peter Olins, John Thomas, Maire Caparon, Alan Easton, Barbara Klein, S. Christopher Bauer, Mark Abrams, Kumnan Paik, Sarah Braford-Goldberg
  • Methods of using multivariant IL-3 hematopoiesis fusion protein
    Patent number: 6361977
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 26, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John W. Thomas
  • Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
    Patent number: 6361976
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 26, 2002
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John W. Thomas
  • G-CSF receptor agonists
    Patent number: 6358505
    Abstract: Disclosed are novel G-CSF receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: March 19, 2002
    Inventors: Linda Zurfluh, Barbara Klein, Charles McWherter, Yiping Feng, John McKearn, Sarah Braford-Goldberg
  • Thrombopoietin: IL-3 fusion protein
    Patent number: 6254870
    Abstract: The present invention relates to variants of human c-mpl ligands (thrombopoietin) with activity on hematopoietic differentiation and expansion.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: July 3, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Nicholas R. Staten, Jean P. Favara, Larry E. Kahn, Lyle E. Pegg, John P. McKearn, Charles M. Baum
  • Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
    Patent number: 6066318
    Abstract: Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: May 23, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Yiqing Feng, Nicholas R. Staten, Charles M. Baum, Neena L. Summers, Maire Helena Caparon, S. Christopher Bauer, Linda L. Zurfluh, John P. McKearn, Barbara K. Klein, Stephen C. Lee, Charles A. McWherter, Judith G. Giri