Patents Represented by Attorney S. Lazar

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  • Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
    Patent number: 5700774
    Abstract: Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor-.beta. (TGF-.beta.) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: December 23, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Gary Hattersley, Vicki A. Rosen
  • Bone morphogenetic protein -11 (BMP-11) compositions
    Patent number: 5700911
    Abstract: Purified Bone Morphogenetic Protein-11(BMP-11) proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 23, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Anthony J. Celeste