Abstract: High refractive index copolymers comprised of monomers having the formula: ##STR1## wherein X is H or CH.sub.3 ;m is 0-10;Y is nothing, O, S, or NR wherein R is H, CH.sub.3, C.sub.n H.sub.2n+1 ; (n=114 10) iso OC.sub.3 H.sub.7, C.sub.6 H.sub.5, or CH.sub.2 C.sub.6 H.sub.5 ;Ar is an aromatic ring which is unsubstituted or substituted with H, CH.sub.3, C.sub.2 H.sub.5, n-C.sub.3 H.sub.7, iso-C.sub.3 H.sub.7, OCH.sub.3, C.sub.6 H.sub.11, Cl, Br, C.sub.6 H.sub.5 or CH.sub.2 C.sub.6 H.sub.5 ;and n is 1-5; anda cross linking monomer having a plurality of polymerizable ethylenically unsaturated groups are disclosed. Intraocular lenses made of the copolymers which can be inserted into an aphakic eye through a relatively small incision are also disclosed.
Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
Type:
Grant
Filed:
April 10, 1992
Date of Patent:
December 21, 1993
Assignee:
Alcon Laboratories, Inc.
Inventors:
Stella M. Robertson, Herman M. Kunkle, Jr.
Abstract: Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
Type:
Grant
Filed:
October 9, 1991
Date of Patent:
August 31, 1993
Assignee:
Alcon Laboratories, Inc.
Inventors:
Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
Abstract: Irrigating solutions with thiol or disulfide containing compounds in physiologically acceptable salt solutions are described. The irrigating solutions are useful during surgery, particularly ophthalmic, neural, cardiovascular or otic surgery, to stabilize the affected tissue. Methods for their preparation and use are described.
Type:
Grant
Filed:
July 13, 1992
Date of Patent:
June 22, 1993
Inventors:
Gerald Hecht, Michael E. Stern, Romulus K. Brazzell
Abstract: The use of monoacyl phosphoglycerides to enhance the penetration of topically applied ophthalmic drugs through the corneal epithelium is described.
Type:
Grant
Filed:
February 7, 1991
Date of Patent:
June 22, 1993
Assignee:
Alcon Laboratories, Inc.
Inventors:
Tai-Lee Ke, Eugene R. Cooper, Douglas F. Hager, Jamieson C. Keister
Abstract: Ophthalmic compositions comprising combinations of gelling polysaccharides and finely-divided drug carrier substrates which become relatively more viscous on contact with the eye are disclosed. These ophthalmic compositions are both comfortable and long-lasting Ophthalmic compositions further comprising a pharmaceutically active drug are also disclosed, as are methods of use.
Type:
Grant
Filed:
March 25, 1992
Date of Patent:
May 18, 1993
Assignee:
Alcon Laboratories, Inc.
Inventors:
Paul J. T. Missel, John C. Lang, Rajni Jani
Abstract: Methods for lowering elevated intraocular pressure resulting from the instillation to the eye of sodium hyaluronate during surgery by administration of transition metal complexes are disclosed.
Abstract: Thiophene sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
Type:
Grant
Filed:
November 27, 1990
Date of Patent:
October 6, 1992
Assignee:
Alcon Laboratories, Inc.
Inventors:
Thomas R. Dean, Hwang-Hsing Chen, Jesse A. May
Abstract: A method for polishing articles manufactured from silicone rubber or silicone elastomers is disclosed. This method includes tumble-polishing in a receptacle charged with polishing objects, an alcohol solvent, and silicone articles for a period of time and at a rotation speed sufficient to remove surface irregularities and produce the desired finish and/or improve the optical transparency of the silicone articles. This method is particularly useful in the polishing of biomedical articles such as intraocular or soft contact lenses, tips of cannulae, and articles such as O-rings for precision mechanical devices.
Abstract: Hypotonic contact lens care compositions containing a quaternary ammonium antimicrobial agent (e.g. Polyquad.RTM.) and an anionic complexing agent (e.g. citrate) are disclosed. The compositions are useful in the disinfection of hydrophilic contact lenses, particularly Group IV lenses, and in the preservation of products for treating such lenses. Methods for use of the compositions for disinfecting and preserving are also disclosed.
Type:
Grant
Filed:
September 15, 1988
Date of Patent:
August 6, 1991
Assignee:
Alcon Laboratories, Inc.
Inventors:
Masood A. Chowhan, Danny O. Helton, R. Gregg Harris, Connie L. Luthy
Abstract: Disclosed are esters and amides of (+) suprofen, substantially free of the corresponding enantiomorp, (-) suprofen, having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such (+) suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.
Abstract: Bicomposite, hydrogel intraocular lenses with one or more haptic portions having a lower water content than the corresponding optic portions, and methods for their manufacture are disclosed. The bicomposite lenses are manufactured by (i) preparing a bicomposite button of hydrogel material containing one or more polymers or copolymers; (ii) lathing the button to produce a dehydrated intraocular lens with an optic and at least one haptic; and (iii) hydrating the lens.
Abstract: Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.
Type:
Grant
Filed:
March 23, 1988
Date of Patent:
August 28, 1990
Assignee:
Laboratoirs Alcon S.A.
Inventors:
Gerard LeClerc, Beatrice Ruhland, Guy Andermann, Georges de Burlet, Michel Dietz