Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
Abstract: Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
Type:
Grant
Filed:
December 14, 2001
Date of Patent:
July 22, 2003
Assignee:
Alza Corporation
Inventors:
Patrick S. -L. Wong, David E. Edgren, Liang C. Dong, Crystal Pollock-Dove
Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
Type:
Grant
Filed:
July 13, 2000
Date of Patent:
April 15, 2003
Assignee:
Alza Corporation
Inventors:
Patrick S.-L. Wong, Liang-Chang Dong, David E. Edgren, Felix Theeuwes, Phyllis I. Gardner, Francisco Jao, Jason J. Wan
Abstract: A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.
Type:
Grant
Filed:
September 7, 2000
Date of Patent:
December 10, 2002
Assignee:
ALZA Corporation
Inventors:
Liang-Chang Dong, Patrick S. L. Wong, Atul Devdatt Ayer, Padmaja Shivanand, Michael A. DesJardin
Abstract: A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.
Type:
Grant
Filed:
May 25, 2001
Date of Patent:
July 16, 2002
Assignee:
Alza Corporation
Inventors:
Patrick S. -L. Wong, Liang C. Dong, Jiansheng Wan
Abstract: Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
Type:
Grant
Filed:
December 22, 1999
Date of Patent:
January 29, 2002
Assignee:
Alza Corporation
Inventors:
Patrick S. -L. Wong, David E. Edgren, Liang C. Dong, Crystal Pollock-Dove
Abstract: This invention pertains to a dosage form for the management of epilepsies wherein the dosage form comprises administering valproic acid or a valproic acid derivative at a continuous rate over an extended time.
Type:
Grant
Filed:
May 28, 1993
Date of Patent:
September 11, 2001
Assignee:
Alza Corporation
Inventors:
Atul Devatt Ayer, Richard L.-C. Yieh, Brenda J. Pollock, Patrick S.-L. Wong