Patents Represented by Attorney, Agent or Law Firm Samuel M. Freund
  • Patent number: 7563484
    Abstract: Immersion precipitation of solutions having 15%-30% (w/w) and various molecular weights of the emeraldine base form of polyaniline in polar aprotic solvents are shown to form integrally skinned asymmetric membranes and fibers having skin layers <1 ?m thick which exhibit improved rates of gas transport while preserving good selectivity. These membranes can be further transformed by an acid doping process after fabrication to achieve excellent permeation rates and high selectivities for particular gas separations. Prior to the use of concentrated EB solutions, the formation of integrally skinned asymmetric membranes was not possible, since films and fibers made from <5% w/w polyaniline solutions were found to disintegrate during the IP process.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: July 21, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Hsing-Lin Wang, Benjamin R. Mattes
  • Patent number: 7228740
    Abstract: An apparatus for noninvasively monitoring the flow and/or the composition of a flowing liquid using ultrasound is described. The position of the resonance peaks for a fluid excited by a swept-frequency ultrasonic signal have been found to change frequency both in response to a change in composition and in response to a change in the flow velocity thereof. Additionally, the distance between successive resonance peaks does not change as a function of flow, but rather in response to a change in composition. Thus, a measurement of both parameters (resonance position and resonance spacing), once calibrated, permits the simultaneous determination of flow rate and composition using the apparatus and method of the present invention.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: June 12, 2007
    Assignee: Los Alamos National Security, LLC
    Inventor: Dipen N. Sinha
  • Patent number: 6959601
    Abstract: An apparatus for noninvasively monitoring the flow and/or the composition of a flowing liquid using ultrasound is described. The position of the resonance peaks for a fluid excited by a swept-frequency ultrasonic signal have been found to change frequency both in response to a change in composition and in response to a change in the flow velocity thereof. Additionally, the distance between successive resonance peaks does not change as a function of flow, but rather in response to a change in composition. Thus, a measurement of both parameters (resonance position and resonance spacing), once calibrated, permits the simultaneous determination of flow rate and composition using the apparatus and method of the present invention.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: November 1, 2005
    Assignee: The Regents of the University of California
    Inventor: Dipen N. Sinha
  • Patent number: 6889560
    Abstract: An apparatus for noninvasively monitoring the flow and/or the composition of a flowing liquid using ultrasound is described. The position of the resonance peaks for a fluid excited by a swept-frequency ultrasonic signal have been found to change frequency both in response to a change in composition and in response to a change in the flow velocity thereof. Additionally, the distance between successive resonance peaks does not change as a function of flow, but rather in response to a change in composition. Thus, a measurement of both parameters (resonance position and resonance spacing), once calibrated, permits the simultaneous determination of flow rate and composition using the apparatus and method of the present invention.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of California
    Inventor: Dipen N. Sinha
  • Patent number: 6867042
    Abstract: A solubility reporter for measuring a protein's solubility in vivo or in vitro is described. The reporter, which can be used in a single living cell, gives a specific signal suitable for determining whether the cell bears a soluble version of the protein of interest. A pool of random mutants of an arbitrary protein, generated using error-prone in vitro recombination, may also be screened for more soluble versions using the reporter, and these versions may be recombined to yield variants having further-enhanced solubility. The method of the present invention includes “irrational” (random mutagenesis) methods, which do not require a priori knowledge of the three-dimensional structure of the protein of interest. Multiple sequences of mutation/genetic recombination and selection for improved solubility are demonstrated to yield versions of the protein which display enhanced solubility.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: March 15, 2005
    Assignee: The Regents of the University of California
    Inventor: Geoffrey S. Waldo
  • Patent number: 6835246
    Abstract: Selected micro- and nanoscale, 1-dimensional and 2-dimensional periodic and random structures generated on silicon and other substrates are expected to perform as compliant, thin films for gettering defects and for accommodating lattice and thermal expansion mismatches during heteroepitaxial growth thereon, thereby leading to relatively defect-free, heteroepitaxial films of chosen thicknesses. The as-grown epilayers or completed electronic and optoelectronic devices can be bonded to a second substrate such as glass, or plastic following separation thereof from the substrate on which they were formed using preferential etching of a readily detachable, nanoporous silicon or silicon dioxide layer introduced between the generated structures and the substrate.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: December 28, 2004
    Inventor: Saleem H. Zaidi
  • Patent number: 6828062
    Abstract: The present invention relates to the electrochemistry of conjugated polymers in ionic liquids and the development and fabrication of long-lived, highly stable conjugated polymer electrochemical devices by using ionic liquids as electrolytes. More specially, the invention relates to the use of ionic liquids as electrolytes for the fabrication of long-lived, highly stable electrochemical actuators, electrochemical capacitors and electrochemical batteries having conjugated polymers as active electrodes as well as for the fabrication of long-lived, highly stable electrochromic devices with polyaniline and polythiophene as coloration materials.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: December 7, 2004
    Assignee: Santa Fe Science and Technology, Inc.
    Inventors: Wen Lu, Benjamin R. Mattes, Andrei G. Fadeev
  • Patent number: 6797325
    Abstract: Immersion precipitation of solutions having 15%-30% (w/w) and various molecular weights of the emeraldine base form of polyaniline in polar aprotic solvents are shown to form integrally skinned asymmetric membranes and fibers having skin layers <1 &mgr;m thick which exhibit improved rates of gas transport while preserving good selectivity. These membranes can be further transformed by an acid doping process after fabrication to achieve excellent permeation rates and high selectivities for particular gas separations. Prior to the use of concentrated EB solutions, the formation of integrally skinned asymmetric membranes was not possible, since films and fibers made from <5% w/w polyaniline solutions were found to disintegrate during the IP process.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: September 28, 2004
    Assignee: The Regents of The University of California
    Inventors: Hsing-Lin Wang, Benjamin R. Mattes
  • Patent number: 6790430
    Abstract: Hydrogen is produced from solid or liquid carbon-containing fuels in a two-step process. The fuel is gasified with hydrogen in a hydrogenation reaction to produce a methane-rich gaseous reaction product, which is then reacted with water and calcium oxide in a hydrogen production and carbonation reaction to produce hydrogen and calcium carbonate. The calcium carbonate may be continuously removed from the hydrogen production and carbonation reaction zone and calcined to regenerate calcium oxide, which may be reintroduced into the hydrogen production and carbonation reaction zone. Hydrogen produced in the hydrogen production and carbonation reaction is more than sufficient both to provide the energy necessary for the calcination reaction and also to sustain the hydrogenation of the coal in the gasification reaction. The excess hydrogen is available for energy production or other purposes.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: September 14, 2004
    Assignee: The Regents of the University of California
    Inventors: Klaus S. Lackner, Hans J. Ziock, Douglas P. Harrison
  • Patent number: 6773918
    Abstract: Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate transcriptional activator senses the inducing chemical. Creation of bacterial biosensors is currently restricted by limited knowledge of the genetic systems of bacteria that catabolize xenobiotics. By using mutagenic PCR to change the chemical specificity of the Pseudomonas species CF600 DmpR protein, the potential for engineering novel biosensors for detection of phenols has been demonstrated. DmpR, a well-characterized transcriptional activator of the P. CF600's dmp operon mediates growth on simple phenols. Transcription from Po, the promoter heading the dmp operon, is activated when the sensor domain of DmpR interacts with phenol and mono-substituted phenols.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: August 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Arlene A. Wise, Cheryl R. Kuske, Thomas C. Terwilliger
  • Patent number: 6766141
    Abstract: The present invention includes an apparatus and method for telemetry communication with oil-well monitoring and recording instruments located in the vicinity of the bottom of gas or oil recovery pipes. Such instruments are currently monitored using electrical cabling that is inserted into the pipes; cabling has a short life in this environment, and requires periodic replacement with the concomitant, costly shutdown of the well. Modulated reflectance, a wireless communication method that does not require signal transmission power from the telemetry package will provide a long-lived and reliable way to monitor down-hole conditions. Normal wireless technology is not practical since batteries and capacitors have to frequently be replaced or recharged, again with the well being removed from service. RF energy generated above ground can also be received, converted and stored down-hole without the use of wires, for actuating down-hole valves, as one example.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: July 20, 2004
    Assignee: The Regents of the University of California
    Inventors: Scott D. Briles, Daniel L. Neagley, Don M. Coates, Samuel M. Freund
  • Patent number: 6761999
    Abstract: Charge-transfer materials are demonstrated to be useful for generating femtosecond holographic gratings. Using semiconducting polymers sensitized with varying concentrations of C60, absorption holographic gratings with diffraction efficiencies of 1.6% were recorded with individual ultrafast laser pulses; the diffraction efficiency and time decay of the gratings were measured using nondegenerate four-wave mixing. High quantum efficiency for electron transfer reduces the effects of early recombination which otherwise limits the density of excitations in pure polymers, and the metastability of the charge transfer enables tuning of the decay dynamics by controlling the concentration of acceptors in the mixture.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: July 13, 2004
    Assignee: The Regents of the University of California
    Inventors: Eric S. Maniloff, Duncan W. McBranch, Alan J. Heeger, Dan V. Vacar
  • Patent number: 6734964
    Abstract: A low-power, plasma source-based, portable molecular light emission generator/detector employing an atmospheric pressure pulsed-plasma for molecular fragmentation and excitation is described. The average power required for the operation of the plasma is between 0.02 W and 5 W. The features of the optical emission spectra obtained with the pulsed plasma source are significantly different from those obtained with direct current (dc) discharge higher power; for example, strong CH emission at 431.2 nm which is only weakly observed with dc plasma sources was observed, and the intense CN emission observed at 383-388 nm using dc plasma sources was weak in most cases. Strong CN emission was only observed using the present apparatus when compounds containing nitrogen, such as aniline were employed as samples. The present apparatus detects dimethylsulfoxide at 200 ppb using helium as the plasma gas by observing the emission band of the CH radical.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 11, 2004
    Assignee: The Regents of the University of California
    Inventors: Yixiang Duan, Zhe Jin, Yongxuan Su
  • Patent number: 6712479
    Abstract: The present invention includes maintaining the region of the proximal lens of a laparoscope at greater than ambient temperature in order to prevent fogging during use. Heating is accomplished using commercially available chemical heat packs generally used for heating boots or gloves, or by using electrically powered heating tape. The invention differs from other anti-fogging devices, which either immerse the distal lens region of the laparoscope in a warm fluid or treat this lens with anti-fogging solutions, in that above-ambient temperature is continuously maintained throughout the laparoscope, since it is known that a cool laparoscope fogs when placed in the vicinity of warm, wet patient tissue.
    Type: Grant
    Filed: April 22, 2000
    Date of Patent: March 30, 2004
    Assignee: Innovative Surgical Technology, Inc.
    Inventors: Michael R. Seitzinger, David Platts
  • Patent number: 6693989
    Abstract: An apparatus and method for the generation of ultrabright multikilovolt x-rays from saturated amplification on noble gas transition arrays from hollow atom states is described. Conditions for x-ray amplification in this spectral region combine the production of cold, high-Z matter, with the direct, selective multiphoton excitation of hollow atoms from clusters using ultraviolet radiation and a nonlinear mode of confined, self-channeled propagation in plasmas. Data obtained is consistent with the presence of saturated amplification on several transition arrays of the hollow atom Xe(L) spectrum (&lgr;˜2.9 Å). An estimate of the peak brightness achieved is ˜1029 &ggr;·s−1·mm−2·mr−2 (0.1% Bandwidth)−1, that is ˜105-fold higher than presently available synchotron technology.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: February 17, 2004
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Charles K. Rhodes, Keith Boyer
  • Patent number: 6667825
    Abstract: Electrochemical synthesis of conjugated polymers in ionic liquids, achievement of electroactivity and electrochroism of conjugated polymers in ionic liquids, and the use of the resulting conjugated polymers for the fabrication of electrochromic devices incorporating ionic liquids as electrolytes are described.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: December 23, 2003
    Assignee: Santa Fe Science and Technology, Inc.
    Inventors: Wen Lu, Benjamin R. Mattes, Andrei G. Fadeev, Baohua Qi
  • Patent number: 6646241
    Abstract: A surgical and dental instrument sterilizer is described. Liquid water is rapidly vaporized by microwave heating and steam is generated to attain a steam pressure of approximately 47 psi and a temperature of approximately 135° C. in the region of the articles to be sterilized. Micron-size water-droplets are intermittently sprayed onto the articles which are arranged on a tray, from both the top and from underneath thereof so as to thoroughly wet the surfaces. A 30-90 s duration of droplet spray is followed by pulsed microwave irradiation of the top and underneath surfaces for a similar period, as an example; this is followed by a plurality of spray/microwave cycles.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 11, 2003
    Assignee: Ecofriend Technologies, Inc.
    Inventors: Ravi Varma, Worth F. Vaughan
  • Patent number: 6644119
    Abstract: An apparatus for noninvasively monitoring the flow and/or the composition of a flowing liquid using ultrasound is described. The position of the resonance peaks for a fluid excited by a swept-frequency ultrasonic signal have been found to change frequency both in response to a change in composition and in response to a change in the flow velocity thereof. Additionally, the distance between successive resonance peaks does not change as a function of flow, but rather in response to a change in composition. Thus, a measurement of both parameters (resonance position and resonance spacing), once calibrated, permits the simultaneous determination of flow rate and composition using the apparatus and method of the present invention.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: November 11, 2003
    Assignee: The Regents of the University of California
    Inventor: Dipen N. Sinha
  • Patent number: 6613509
    Abstract: The determination of base (nucleotide) composition in DNA by mass spectrometry is described. Accurate and efficient analyses of the enormous pool of DNA sequences are required for; (a) validation of DNA sequences; (b) comparison of a parent (known) sequence with a related (unknown) sequence, and (c) characterization of sequence polymorphisms in various genes especially those associated with genetically inherited human diseases. The combination of stable isotope-labeling of PCR products of target sequences with analysis of the mass shifts by mass spectrometry (MS) is shown to provide such analyses, since the mass-shift due to the labeling of a single type of nucleotide (i.e., A, T, G, or C) identifies the number of that type of nucleotide in a given DNA fragment. Accurate determinations of nucleotide compositions of DNA fragments have been achieved with an accuracy of ±0.03% with respect to their known sequences. The method has also been applied to identify a known single-nucleotide polymorphism (SNP).
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: September 2, 2003
    Assignee: Regents of the University of California
    Inventor: Xian Chen
  • Patent number: 6593275
    Abstract: Increasing the concentration of prolines, such as 2-hydroxy-5-oxoproline, in the foliar portions of plants has been shown to cause an increase in carbon dioxide fixation, growth rate, dry weight, nutritional value (amino acids), nodulation and nitrogen fixation, photosynthetically derived chemical energy, and resistance to insect pests over the same properties for wild type plants.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: July 15, 2003
    Assignee: The Regents of the University of California
    Inventors: Pat J. Unkefer, Thomas J. Knight, Rodolfo A. Martinez