Patents Represented by Attorney Samuel S. Welt

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  • Resolution of D,L-dehydroproline
    Patent number: 4066658
    Abstract: D,L-3,4-dehydroproline is resolved in high optical yield by conversion to its N-protected derivative, treatment with R(+)alpha-methyl-p-nitrobenzylamine to form the diastereomeric salts, fractional crystallization, decomposition of the L-R salt and regeneration of the secondary amine group. The product L-3,4-dehydroproline obtained in extremely high optical purity is useful as an inhibitor of collagen synthesis.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: January 3, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Arthur Martin Felix