Abstract: A process for producing new anticancer drugs such that the drugs can be administered in a nontoxic, proto-drug form and, subsequent to a time delay which allows for differential concentration in the target cancer or invasive tissues or cells, the non-toxic drug is then modified by an activation drug to selectively provide toxic levels of a pharmacologically active agent to the target issue.
Type:
Grant
Filed:
December 17, 2002
Date of Patent:
July 27, 2004
Assignee:
Walker Cancer Research Institute, Inc.
Inventors:
Evan Harris Walker, Eduardo Palomino, Steven L. Blumenthal