Abstract: The methods and compositions provided herein relate generally to IL-10 specific antibodies and uses thereof. More specifically, the methods and compositions provided herein relate to humanized IL-10 specific antibodies and methods to use such antibodies in modulating the biological activity of IL-10, particularly in autoimmune disorders and pathogen-mediated immunopathology.
Abstract: The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
Type:
Grant
Filed:
December 19, 2007
Date of Patent:
February 9, 2010
Assignee:
Schering Corporation
Inventors:
Alexander B. H. Bakker, Joseph H. Phillips, Lewis L. Lanier
Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
Abstract: Nucleic acids encoding a new family of small cysteine rich soluble proteins, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
Type:
Grant
Filed:
September 18, 2002
Date of Patent:
July 14, 2009
Assignee:
Schering Corporation
Inventors:
Karin Franz-Bacon, Daniel M. Gorman, Terrill K. McClanahan
Abstract: Provided herein are methods of modulating IL-33 activity, e.g., for the purpose of treating immune diseases and conditions, as well as methods of screening for compounds capable antagonizing IL-33 signaling.
Type:
Grant
Filed:
July 18, 2007
Date of Patent:
July 14, 2009
Assignee:
Schering Corporation
Inventors:
Alissa A. Chackerian, Robert A. Kastelein
Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.
Type:
Grant
Filed:
December 8, 2006
Date of Patent:
September 23, 2008
Assignee:
Schering Corporation
Inventors:
Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy, Jason R. Chan