Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
February 11, 2004
Date of Patent:
August 25, 2009
Assignee:
Schering Corporation
Inventors:
Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
Type:
Grant
Filed:
February 5, 2008
Date of Patent:
August 18, 2009
Assignee:
Schering Corporation
Inventors:
Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Jason R. Chan
Abstract: Flt3 ligand from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said ligand. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
May 26, 2009
Assignees:
Schering Corporation, Inserm
Inventors:
Charles H. Hannum, Janice A. Culpepper, Frank D. Lee, Daniel Birnbaum
Abstract: Flt3 ligand from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said ligand. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
May 19, 2009
Assignees:
Schering Corporation, Inserm
Inventors:
Charles H. Hannum, Janice A. Culpepper, Frank D. Lee, Daniel Birnbaum
Abstract: Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
Type:
Grant
Filed:
May 2, 2005
Date of Patent:
March 10, 2009
Assignee:
Schering Corporation
Inventors:
Robert A. Kastelein, Terrill K. McClanahan, Erin Murphy
Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
Type:
Grant
Filed:
June 18, 2007
Date of Patent:
February 17, 2009
Assignee:
Schering Corporation
Inventors:
Rene De Waal Malefyt, Helmut Fickenscher, Bernhard Fleckenstein, Andrea Knappe