Patents Represented by Attorney, Agent or Law Firm Schiller & Associates
  • Patent number: 6190550
    Abstract: A method of monitoring performance of liquid chromatography apparatus comprising an elongated chromatography column and having a conduit coupled to the column inlet for introducing a flow of liquid into said column preferably at very high pressure. Variations in a selected electromagnetic property, such as the electrical conductivity, of the liquid flow are measured, preferably in the conduit. Apparatus is configured so that respective volumes of sample liquid and eluant may be introduced into the conduit sequentially or substantially simultaneously with substantially no band-spreading when flowing through the conduit into the column. A pair of electrically conductive electrodes, coupled to metering means, are positioned at two spaced-apart locations within the conduit and are electrically insulated from each other and from the ends of the conduit.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: February 20, 2001
    Assignee: Cohesive Technologies, Inc.
    Inventor: Charles J. Oberhauser
  • Patent number: 6149816
    Abstract: A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30 .mu.m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: November 21, 2000
    Assignee: Cohesive Technologies, Inc.
    Inventors: Hubert M. Quinn, John E. Brann, III
  • Patent number: 6110362
    Abstract: A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30 .mu.m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: August 29, 2000
    Assignee: Cohesive Technologies, Inc.
    Inventors: Hubert M. Quinn, John E. Brann, III
  • Patent number: 6071365
    Abstract: Apparatus for and process of folding and securing edges of a relatively large wrap over corresponding edges of a smaller board positioned on and in contact with an adhesively coated surface of the wrap to form a laminated work-piece, the work-piece being moved in a first direction to a first wrapping head having a pair of movable jaws defining a slot. An edge if the sheet extending from the work-piece, is engaged and folded over a corresponding edge of the board and adhesively adheres to the opposite surface of the board. The folded-over edge is then clamped between the jaws of the first wrapping head and carried in that manner in an opposite direction in a parallel but displaced second plane to a similar slot in a second, like, wrapping head. At the latter, the opposite edge of the sheet extending from the work-piece is similarly engaged, folded over and adhered to the board.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: June 6, 2000
    Assignee: Crathern Engineering Co., Inc.
    Inventor: Thomas M. Porat