Abstract: Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.
Type:
Grant
Filed:
July 26, 1999
Date of Patent:
March 19, 2002
Assignee:
NeoRx Corporation
Inventors:
Lawrence L. Kunz, Richard A. Klein, John M. Reno