Abstract: Compounds and methods are provided to treat inflammatory conditions with certain A2A adenosine receptor antagonists.

Abstract: An integrated circuit is described which has circuitry to detect environmental conditions such as temperature and supply voltage and adjust the operation of the circuit accordingly. A flash memory system is described which includes a temperature detector and a supply voltage detector. The memory monitors temperature and voltage and adjusts an oscillator circuit to maintain an ideal operating frequency. The oscillator includes adjustable delay stages which can be selectively fed back to adjust operating frequency. To save power, unused delay stages of the oscillator can be disabled. Oscillator calibration circuitry, a temperature detector, and a voltage detector are described.

Abstract: A thermal cycling device comprising a ceramic sample plate, and method of use thereof, is provided.

Abstract: A connector apparatus system and method for providing a direct electrical connection to an implanted medical device for recharging batteries, reprogramming memory, or accessing data. The apparatus consists of a needle-like male connector in conjunction with an implantable female connector that is attached to the implanted medical device and contains a self-resealing elastomeric septum entry port. The female connector comprises a recepticle chamber that is densely packed with a plurality of randomly intertwining, thin, flexible, and conductive metal fibers. External battery charging equipment can be connected to the implanted medical device's internal battery with the connector apparatus system. The required circuit path for recharging can be completed by the use of two single polarity connector pairs, one single polarity connector pair in conjunction with a grounding plate, or one bipolar connector pair.

Abstract: A transgenic mouse is provided, the cells of which contain and express IL-5 in a cell type- or tissue-specific manner and in an amount which results in an IL-5-associated pathology. Also provided are expression cassettes comprising an IL-5 gene, operably linked to a cell type- or tissue-specific transcriptional control sequence and methods of using transgenic mice comprising the expression cassettes.

Abstract: Immortalized normal human fetal osteoblastic cells that express a temperature sensitive mutant of simian virus 40 large T antigen are provided.