Abstract: What is disclosed are growth hormone secretagogues, and their uses, of the formula
wherein R1 is C6H5CH2OCH2—, C6H5 (CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6 alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1 to C6 alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6 alkoxy or phenyl; and R4 is H or CH3,
or a pharmaceutically acceptable salt or solvate thereof.
Type:
Grant
Filed:
July 25, 2001
Date of Patent:
December 7, 2004
Assignee:
Eli Lilly and Company
Inventors:
Jeffrey Alan Dodge, Charles Willis Lugar, III
Abstract: This invention relates to novel compounds of formula I
wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
Type:
Grant
Filed:
April 17, 2001
Date of Patent:
October 28, 2003
Assignee:
Eli Lilly and Company
Inventors:
Kenneth Lee Hauser, Jeffrey Alan Dodge, Mark Louis Heiman, Scott Alan Jones, Charles Arthur Alt, Henry Uhlman Bryant, James Densmore Copp, William Harlan Gritton, Charles Willis Lugar, III, Brian Stephen Muehl, Alan David Palkowitz, Andrew Michael Ratz, Gary Anthony Rhodes, Roger Lewis Robey, Timothy Alan Shepherd, Kenneth Jeff Thrasher, William George Trankle
Abstract: The present invention is directed to methods for the modulation of cardiac function which comprise the administration of certain compounds, as defined herein, having growth hormone secretagogue activity.
Abstract: The striking surface of a golf club is constructed of a fiber reinforced composite insert. The insert is formed of a metal striking surface having at least one layer of backing comprising a ply of fibers in a metal matrix laminated to the back of the striking surface. The insert is secured to the face of the golf club for engagement with the ball.
Type:
Grant
Filed:
April 13, 1995
Date of Patent:
July 14, 1998
Assignee:
Textron Systems Corporation
Inventors:
Michael Eugene Buck, Stephen Anthony Kraus, Thomas William Shahood
Abstract: A porous preform is densified by heating while emersed in a precursor liquid. Heating is achieved by passing a current through the preform or by an induction coil immersed in the liquid. Ways to control the densification process are also described.
Type:
Grant
Filed:
March 29, 1995
Date of Patent:
March 31, 1998
Assignee:
Textron Systems Corporation
Inventors:
Garrett S. Thurston, Raymond J. Suplinskas, Thomas J. Carroll, Donald F. Connors, Jr., David T. Scaringella, Richard C. Krutenat
Abstract: A process for manufacturing a metallized substrate using the island coating method, includes depositing a coating layer containing a radiation curable non-volatile film former. The coated part is then vacuum metallized to form the metal islands of the present invention. A layer of clear resinous protective dielectric topcoat containing a radiation curable non-volatile film former is then deposited to completely cover the layer of metal islands while maintaining the aesthetic properties of the metallizing island coating system at a reduced cost and with minimal variability among parts.
Type:
Grant
Filed:
December 18, 1996
Date of Patent:
January 27, 1998
Assignee:
Textron Automotive Interiors Inc.
Inventors:
Maureen M. Lein, Mark E. Dukeshire, Richard W. Finch, Alfred T. Poliquin, Gerard L. Vachon
Abstract: A fiber blend for use in friction materials. The fiber contains a blend of a highly fibrillated fiber, such as a fibrillated polyacrylonitrile fiber and a fiber with a high carbon content, such as an oxidized carbon fiber precursor.