Abstract: Monoclonal antibodies (MAb) are provided which have binding specificity to an antigen expressed on osteogenic and fibroblastic cells (OFA) and are capable of binding to osteogenic and fibroblastic cells at a substantially higher extent as compared to their binding to skin fibroblasts and stromal adipocytes. Also provided is a novel osteogenic and fibroblastic antigen (OFA) which is expressed on osteogenic and fibroblastic cells at a higher level than its expression in skin fibroblasts and stromal adipocytes having a molecular weight of about 80 kD as determined by western blotting or immunoprecipitation. The OFA and anti-OFA-MAbs are useful in the diagnosis and treatment of various hone related conditions.
Abstract: Topical gelled compositions comprising a drug for treating sexual dysfunction dispersed within a polymer matrix and methods and treatments using said compositions.
Type:
Grant
Filed:
March 26, 1998
Date of Patent:
March 14, 2000
Assignee:
L.A.M. Pharmaceutical Corp.
Inventors:
Alan Drizen, Peter Rothbart, Gary M. Nath
Abstract: Sustained release compositions comprising a drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.
Type:
Grant
Filed:
January 8, 1998
Date of Patent:
December 28, 1999
Assignee:
LAM Pharmaceuticals Corp.
Inventors:
Alan Drizen, Peter Rothbart, Gary M. Nath