Abstract: The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.

Abstract: This invention relates to treatment of dry eye. In particular, the invention relates to methods and formulations for treating dry eye based on topical application of opioid antagonists such as naltrexone.

Abstract: Compounds of formula (I): in which: X, R1, R2, R3 and R4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.

Abstract: The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of patients with ischemic heart diseases such as coronary heart disease or ischemic cardiomyopathy. Treatment of such cells which are isolated from bone marrow, for example, with an eNOS transcription enhancer prior to their administration improves their functional activity and ameliorates neovascularization of the heart and cardiac regeneration.

Abstract: A method to achieve multiple threshold voltage (Vt) devices on the same semiconductor chip is disclosed. The method provides different threshold voltage devices using threshold voltage adjusting materials and a subsequent drive in anneal instead of directly doping the channel. As such, the method of the present disclosure avoids short channel penalties. Additionally, no ground plane/back gates are utilized in the present application thereby the method of the present disclosure can be easily integrated into current complementary metal oxide semiconductor (CMOS) processing technology.

Abstract: The present invention provides a catalyst comprising metallic Pt and/or Pd supported on a binder-free zeolite for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock, wherein the amount of metallic Pt and/or Pd is of 0.01-0.8 wt %, preferably 0.01-0.5 wt % on the basis of the total weight of the catalyst, and the binder-free zeolite is selected from the group consisting of mordenite, beta zeolite, Y zeolite, ZSM-5, ZSM-11 and composite or cocrystal zeolite thereof. The present invention also provides a process for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock using said catalyst.

Abstract: Bicyclic pyrazole and isoxazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases mediated by HSP90 protein, like cancer and neurodegenerative disorders.

Abstract: A technology is disclosed for easily executing a compositional analysis to obtain a preferred composition. Image data is acquired, the image data is analyzed, and a plurality of composition lines expressing the feature of the image data on the composition are acquired. On the composition formed of the plurality of acquired composition lines, the ratio of lengths of two sides selected from the plurality of sides in the region partitioned by the plurality of composition lines is detected to be a specified value (for example, the golden ratio).

Abstract: An endoscope system includes an endoscope with a bending portion installed on a distal side of an insertion portion; a bending drive unit which drives and bends the bending portion electrically; a map information storage unit which stores map information digitized by associating an amount of bending and a corresponding three-dimensional position and direction of a distal end of the insertion portion with each other, with a position near a rear end of the bending portion being designated as a reference position; a position and direction detecting unit which detects the position and direction of the distal end of the insertion portion; and a bending control unit which controls the bending drive unit to orient the distal end of the insertion portion into a target direction using the map information.

Abstract: A system and method for automatically configuring a display device for an endoscopic procedure. The system includes: a video processing device for receiving image signals of an object from an endoscope device. A first converting device converts the image signals provided by a standard definition endoscope device into first resolution video image signals for display on a display device; or, converts image signals provided by a high definition endoscope device into second higher resolution video image signals for display. A second converting device converts the second higher resolution video image signals into first resolution video image signals image signals. A processing node receives: the first resolution video image signals from either the first converter means, or from the second converter means. An image capture means at the processing node captures still images of the first resolution video image signals received.

Abstract: A medical information management apparatus is provided which enables the person in charge of the medical services to easily keep track of the amount of services. In a medical information management apparatus according to the present invention, a task information storing unit stores the information indicating the completion of task execution or the progress of task to be executed for the task generated in a plurality of the medical services. A task number counting unit counts for each medical service the number of the tasks to be executed, and a display control unit displays for the respective medical service the number of the counted tasks on a display apparatus.

Abstract: A power transmission system includes a loosely coupled air core transformer having a resonance frequency determined by a product of inductance and capacitance of a primary circuit including a primary coil. A secondary circuit is configured to have a substantially same product of inductance and capacitance. A back EMF generating device (e.g., a battery), which generates a back EMF with power transfer, is attached to the secondary circuit. Once the load power of the back EMF generating device exceeds a certain threshold level, which depends on the system parameters, the power transfer can be achieved at higher transfer efficiency if performed at an operating frequency less than the resonance frequency, which can be from 50% to 95% of the resonance frequency.

Abstract: The present invention provides a composite solid acid catalyst consisting of from 50%-80% by weight of a porous inorganic support, from 15% to 48% by weight of a heteropoly compound loaded thereon, and from 2% to 6% by weight of an inorganic acid. The present invention further provides a process for preparing said composite solid acid catalyst and a process for conducting an alkylation reaction by using such catalyst. The composite solid acid catalyst of the present invention has the acid sites type of Brönsted acid and has an acid sites density of not less than 1.4×10?3 mol H+/g. Moreover, said composite solid acid catalyst has the homogeneous acid strength distribution, and is a solid acid catalyst having excellent performances.

Abstract: An endoscopic treatment instrument having a treatment portion having: an input member; a first link disconnectably connected to the input member; a first control plate disposed in a first connecting portion, inserting the input member through the first control plate, and engaging the input member by inclination of the first control plate; a first forceps member opening and closing according to advancing and retracting motions of the first link; a second link disconnectably connected to the input member; a second control plate disposed in a second connecting portion, inserting the input member through the second control plate, and engaging the input member by inclination of the second control plate; and a second forceps member opening and closing according to advancing and retracting motions of the second link, the opening-and-closing angle of the second forceps member being less than that of the first forceps member.

Abstract: Providing element dossiers may include obtaining records of relationships between elements from all lifecycle phases of interest, and querying and retrieving a list of all elements related to a target element using the relationship records including relationships between intermediary adjacent lifecycle phases. The method also includes determining inferential and correlation based relationships among dynamically changing elements.

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R?1; R is selected from the group comprising Formula (A?), (B), (C), (D), or (E), with R1 and/or R?1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkylhio, or carboxy that is free or esterified by an alkyl, carboxamide, CO—NH(alkyl), CON(alkyl)2, NH—CO-alkyl, sulfonamide, NH—S02-alkyl, S(0)2-NHalkyl, or S(02)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is 0, S, NR2, C(O), S(O), or S(0)2; Z is optionally substituted H, Hal, -0-R2 or —NH—R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs.

Abstract: A master device sends a request to communicate with a slave device to a switch. The master device waits for a period of cycles the switch takes to decide whether the master device can communicate with the slave device, and the master device sends data associated with the request to communicate at least after the period of cycles has passed since the master device sent the request to communicate to the switch without waiting to receive an acknowledgment from the switch that the master device can communicate with the slave device.

Abstract: he present invention has disclosed a compound of formula I and a pharmaceutically acceptable salt or a solvate thereof, wherein the substituents are as defined in the description. The invention has also disclosed a method for preparing the compound of formula I, the pharmaceutical compositions comprising the same and their uses in the preparation of an anti-tumor medicament.