Abstract: A retrograde well region, having a buried layer of high conductivity, is formed in a semiconductor substrate. A trench structure is selectively etched in the semiconductor substrate down to a region proximate to or within the buried layer. A conducting local interconnect material is formed within and proximate to the trench structure to electrically connect surface portions of the substrate to the buried layer. The buried layer is used to provide a voltage source to an integrated circuit. In one application, a P-type buried layer provides ground potential or VSS to a source region of an N-channel FET transistor. In a second application, an N-type buried layer provides supply potential or VCC to a source of a P-channel FET transistor.
Abstract: A memory-cell array includes several memory cells arranged in rows and columns. The memory cells in each row include an access terminal coupled to an associated word line. The memory cells in each column are coupled between a respective first digit line and a respective complementary digit line. The complementary digit line is divided into several portions. A sense amplifier has first and second data terminals with the first data terminal coupled to the first digit line. The memory-cell array includes several first isolation devices, each first isolation device selectively coupling an associated portion of the complementary digit line to the second data terminal of the sense amplifier.
Abstract: Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
December 31, 1997
Date of Patent:
June 19, 2001
Adherex Technologies, Inc.
Orest W. Blaschuk, James Matthew Symonds, Barbara J. Gour
Abstract: A new bar code symbology in an exemplary embodiment employs three bars (and spaces) within nine modules, similar to Code 93. Fifty-three data characters are defined, including several special mode characters. By employing these special mode characters, together with certain routines, three symbol characters can represent two 8-bit bytes, or one 16-bit word. As a result, the symbology can efficiently encode 8-bit bytes for use in computer processing, or encode 16-bit character sets such as Unicode. Symbology encodes extended channel interpretation (ECI) numbers, provides multiple numeric compression modes, provides a structured append using a single mode character, as well as other features.
Abstract: A method and apparatus for mechanically and/or chemical-mechanically planarizing microelectronic substrates. In one embodiment in accordance with the principles of the present invention, a microelectronic substrate is planarized or polished on a planarizing medium having a thin film and a plurality of micro-features on the film. The film may be an incompressible sheet or web substantially impervious to a planarizing solution, and the micro-features may be configured in a selected pattern on the film to restrain fluid flow of the planarizing solution across the surface of the film under the substrate. The micro-features, for example, may be configured in a selected pattern that has a plurality of support points and at least one cavity to entrap a substantially contiguous, uniform distribution of the solution under the substrate during planarization.
Abstract: Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Le.sup.a and di-sialyl Le.sup.a, which are expressed at the surface of cancer cells, function as a binding partner for LEC-CAMs, such as ELAM-1, which are expressed at the surface of endothelial cells. The present invention also discloses that LEC-CAMs, such as ELAM-1, involved in cancer metastasis share a carbohydrate domain common to both sialyl Le.sup.a and sialyl Le.sup.x. Antibodies, saccharides, glycoconjugates, enzyme inhibitors and other compounds may be used in the methods of the present invention to inhibit the binding of malignant cells to endothelial cells for a variety of purposes in vivo and in vitro.
May 5, 1994
Date of Patent:
September 19, 2000
John L. Magnani
John L. Magnani, Eugene C. Butcher, Ellen L. Berg
Abstract: The PHA biosynthetic pathway is combined with a succinic semialdehyde metabolic pathway that metabolizes succinic semialdehyde via a 4-hydroxybutyryl-CoA intermediate in order to produce high levels of PHA comprising 4HB monomer units. This combination is particularly useful, in part, because the PHA biosynthetic pathway is well known and has been expressed to produce P(3HB) to levels as high as 70-80% of the cell dry weight, while the succinic semialdehyde metabolic pathway is also well known, and the combination of the two pathways means that production of PHAs comprising 4HB monomer units does not depend on immediate precursors of 4-hydroxybutyrate. Rather, the production of the PHAs comprising 4HB monomer units can occur simply from the extraction of succinate or succinyl-CoA from the citric acid cycle when the host cell is grown on an inexpensive carbon source such as glucose.
Abstract: A integrated circuit, such as a memory integrated circuit, includes a vernier clock adjustment circuit receiving an input clock signal and providing a rising-edge clock signal representing the input clock signal delayed by a rising-edge delay and providing a falling-edge clock signal representing the input clock signal delayed by a falling-edge delay. An edge triggered circuit receives data and the rising-edge and falling-edge clock signals, and stores data at the rising-edge of the rising-edge clock signal and at the falling-edge of the falling-edge clock signal. One form of the invention is a memory system having a memory controller coupled to memory modules through data and command busses. Each memory module includes the vernier clock adjustment circuitry.
Abstract: An ester-terminated dimer acid-based polyamide may be blended with a solvent to form a gel. The solvent may be flammable, and a wick may be added to the resulting gel so as to form a candle. Depending on the composition, the candle may be formed into a free standing pillar, or may be better suited to being placed in a container. The solvent may be mineral oil. A solid coating may be placed around the candle, for advantages including to enhance the mechanical stability of the gelled body, and to eliminate the tendency of a gel to have an oily feel and to accept noticeable fingerprints. The solvent which, in combination with the ester-terminated dimer acid-based polymer forms a gel, may be or include a fragrance material, an insecticide or an insect repellent. A wick may or may not be present in this gel, but in any event, the composition provides for the release of the fragrance, insecticide or insect-repellent.
September 26, 1997
Date of Patent:
August 29, 2000
Union Camp Corporation, Bush Boake Allen
Vivian Berger, Charles R. Frihart, Ronald L. Gordon, Jochen Heydel, Richard C. MacQueen, Mark S. Pavlin, Virgil Williams
Abstract: This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta. and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.
Abstract: A differential clock receiver for a SynchLink-type Synchronous Dynamic Random Access Memory (SLDRAM) includes a differential amplifier with a novel method for biasing its NMOS and PMOS current sources. A differential clock received and amplified by the differential amplifier switches a set of multiplexers, which respond by outputting a differential output clock. The multiplexers can be "disabled" by an inactive enable signal so they output a constant "0" level for the differential output clock. This disabling feature of the differential clock receiver is particularly useful with the intermittent data clocks found in SLDRAMs. Also, the novel biasing method for the current sources of the differential amplifier gives the clock receiver very low skew.
Abstract: An integrated circuit having a passive circuit component that can be adjusted following the manufacturing process to provide a precise absolute value for resistance or capacitance. A plurality of passive elements are selectively combinable using logic gates to include or exclude each element from a network, wherein the combined value of the included passive elements equals the value of the passive circuit component. The logic gates are set by outputs from a decoder to reduce the required inputs to the chip.
Abstract: A driver circuit for slope-controlled pulsed switching of a load having a MOS switching transistor switching the load and a control loop with an amplifier having an amplifier input coupled with a switch control pulse source, an amplifier output connected with the gate of the MOS switching transistor, and a feedback capacitor. The driver circuit also includes a switchable current mirror circuit with a current mirror transistor formed by the MOS switching transistor and a diode transistor wired as a current mirror diode, a connection point between the diode transistor and the gate of the MOS switching transistor being connected with the amplifier output. A timer circuit is supplied on the input side with the switch control pulses from the switch control pulse source, and switches the diode transistor into a conductive state for essentially the duration of each switch control pulse edge and otherwise into a nonconductive state.
Abstract: A method and system for generating a computer program in the manner that uses no computer programming language syntax. The system represents a computer program as an intentional program tree, which is a high-level program tree that is a syntax-independent representation using high-level computational constructs. The intentional program tree represents a programmer's intent, rather than an implementation of the programmer's intent. The programmer creates an intentional program tree using a syntax-independent editor. The editors allows a programmer to directly manipulate the intentional program tree. Because the program is stored as an intentional program tree in a syntax-independent manner, the editor allows the program to select in which of a various programming language the computer program is to be displayed. In addition, the system transforms an intentional program tree to a reduced program tree, which is a program tree comprising low-level computational constructs, in a process called reduction.
Abstract: Compositions and methods for disinfecting bee colonies for preventing or treating diseases in honey bees, honey bee larvae and honey bee hives are disclosed. Such diseases may arise from a variety of sources, including bacteria, fungi, viruses, protozoa and parasites in the hive. Representative diseases preventable or treatable by this invention include Foulbrood and Chalkbrood. The compositions of the present invention include a protic acid and a chlorite ion, and may further include other optional components such as a gelling agent, colorant and/or preservative. Methods disclosed herein include applying the composition to a surface of a bee-hive. Honey produced by bees administered a composition of this invention is also disclosed.
Abstract: There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic and anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis).
Abstract: A method, and DNA constructs useful therein, is provided for producing plasminogen activator in bacteria. Particular constructs are provided comprising a coding sequence for tissue plasminogen activator and the leader peptide thereof, which is used to transform E. coli to produce protein having activity of tissue plasminogen activator.