Abstract: The biological activity of exogenous ligand proteins is enhanced by intravenously co-administering to a mammal the ligand and a soluble receptor protein that binds thereto. Pharmaceutical compositions comprising a ligand protein complexed with a soluble receptor protein are provided. In certain embodiments, the ligand is selected from the group consisting of interleukins, colony stimulating factors, and tumor necrosis factor.
Type:
Grant
Filed:
September 16, 1996
Date of Patent:
May 16, 2000
Assignees:
Immunex Corporation, The United States of America as represented by the Secretary of the Army
Inventors:
Charles R. Maliszewski, Fred D. Finkelman