Abstract: The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms. The invention further provides treatment of cytochrome c oxidase dysfunction.

Abstract: A method and system in a computer system for communicating instructions to an application program in response to spoken commands received by a spoken command input facility is provided. In a preferred embodiment of the present invention, a list of available commands is displayed under the control of the spoken command input facility. Each available command has an instruction associated with it that causes the application program to take some action. The spoken command input facility then determines whether a command spoken by a user is an available command. The spoken command input facility then communicates the instruction associated with the determined available command to the application program. If the spoken command is an available command, the spoken command input facility then revises the displayed list of available commands.