Abstract: The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms. The invention further provides treatment of cytochrome c oxidase dysfunction.
Type:
Grant
Filed:
March 30, 1995
Date of Patent:
January 9, 2001
Assignee:
Mitokor
Inventors:
Corinna Herrnstadt, William Davis Parker